Morphological and skeletal abnormalities induced by α/β arteether on developing chick embryo
Introduction: Malaria continues to be one of the India's leading public health problem.α/β artether is one of the most common antimalarial drug used worldwide to treat chloroquine resistant malaria and malaria falciparum. The present study was designed to assess the teratogenic effects of α/β a...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Acta Medica International |
| Subjects: | |
| Online Access: | http://www.actamedicainternational.com/article.asp?issn=2349-0578;year=2018;volume=5;issue=1;spage=2;epage=13;aulast=Singh |
| _version_ | 1819209351153319936 |
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| author | Vishram Singh Lavlesh Kumar Mittal Ram Kumar Ashoka |
| author_facet | Vishram Singh Lavlesh Kumar Mittal Ram Kumar Ashoka |
| author_sort | Vishram Singh |
| collection | DOAJ |
| description | Introduction: Malaria continues to be one of the India's leading public health problem.α/β artether is one of the most common antimalarial drug used worldwide to treat chloroquine resistant malaria and malaria falciparum. The present study was designed to assess the teratogenic effects of α/β artether on developing chick embryo. Material and Methods: The study was performed on 300 fertilized eggs of white leg horn chicken.The eggs were divided in to five experimental groups A, B, C, D, E having 30 eggs each and five control groups a,b,c,d,e one each for every experimental group respectively having 30 eggs each. On 5th day of incubation eggs from experimental groups A, B, C, D and E were exposed to α/β artether with dose of 0.00039 mg, 0.000585 mg, 0.00078 mg, 0.00097 mg and 0.00117 mg whereas the control groups were treated with same amount of normal saline. Results: The results showed growth retardation and some significant morphological abnormalities like scanty feathers, subcutaneous hemorrhage and skeletal abnormalities like poor ossification of the bones, kyphosis and lordosis. Discussion: The drug is toxic specially when used in higher dose and for a long period. At present there is no alternative drug available for the treatment of chloroquine resistant malaria and malaria falciparum except α/β artether. Therefore α/β artether and other artemisinins should be used only after establishment of proper diagnosis in recommended dose only not in higher dose and not for a long duration. |
| first_indexed | 2024-12-23T05:53:54Z |
| format | Article |
| id | doaj.art-37d95a36c2df4aa88ae75f6dc8a26934 |
| institution | Directory Open Access Journal |
| issn | 2349-0578 2349-0896 |
| language | English |
| last_indexed | 2024-12-23T05:53:54Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Acta Medica International |
| spelling | doaj.art-37d95a36c2df4aa88ae75f6dc8a269342022-12-21T17:57:53ZengWolters Kluwer Medknow PublicationsActa Medica International2349-05782349-08962018-01-015121310.4103/ami.ami_82_17Morphological and skeletal abnormalities induced by α/β arteether on developing chick embryoVishram SinghLavlesh Kumar MittalRam Kumar AshokaIntroduction: Malaria continues to be one of the India's leading public health problem.α/β artether is one of the most common antimalarial drug used worldwide to treat chloroquine resistant malaria and malaria falciparum. The present study was designed to assess the teratogenic effects of α/β artether on developing chick embryo. Material and Methods: The study was performed on 300 fertilized eggs of white leg horn chicken.The eggs were divided in to five experimental groups A, B, C, D, E having 30 eggs each and five control groups a,b,c,d,e one each for every experimental group respectively having 30 eggs each. On 5th day of incubation eggs from experimental groups A, B, C, D and E were exposed to α/β artether with dose of 0.00039 mg, 0.000585 mg, 0.00078 mg, 0.00097 mg and 0.00117 mg whereas the control groups were treated with same amount of normal saline. Results: The results showed growth retardation and some significant morphological abnormalities like scanty feathers, subcutaneous hemorrhage and skeletal abnormalities like poor ossification of the bones, kyphosis and lordosis. Discussion: The drug is toxic specially when used in higher dose and for a long period. At present there is no alternative drug available for the treatment of chloroquine resistant malaria and malaria falciparum except α/β artether. Therefore α/β artether and other artemisinins should be used only after establishment of proper diagnosis in recommended dose only not in higher dose and not for a long duration.http://www.actamedicainternational.com/article.asp?issn=2349-0578;year=2018;volume=5;issue=1;spage=2;epage=13;aulast=SinghArtemisininskyphosislordosisscoliosisteratogenicityα/β arteether |
| spellingShingle | Vishram Singh Lavlesh Kumar Mittal Ram Kumar Ashoka Morphological and skeletal abnormalities induced by α/β arteether on developing chick embryo Acta Medica International Artemisinins kyphosis lordosis scoliosis teratogenicity α/β arteether |
| title | Morphological and skeletal abnormalities induced by α/β arteether on developing chick embryo |
| title_full | Morphological and skeletal abnormalities induced by α/β arteether on developing chick embryo |
| title_fullStr | Morphological and skeletal abnormalities induced by α/β arteether on developing chick embryo |
| title_full_unstemmed | Morphological and skeletal abnormalities induced by α/β arteether on developing chick embryo |
| title_short | Morphological and skeletal abnormalities induced by α/β arteether on developing chick embryo |
| title_sort | morphological and skeletal abnormalities induced by α β arteether on developing chick embryo |
| topic | Artemisinins kyphosis lordosis scoliosis teratogenicity α/β arteether |
| url | http://www.actamedicainternational.com/article.asp?issn=2349-0578;year=2018;volume=5;issue=1;spage=2;epage=13;aulast=Singh |
| work_keys_str_mv | AT vishramsingh morphologicalandskeletalabnormalitiesinducedbyabarteetherondevelopingchickembryo AT lavleshkumarmittal morphologicalandskeletalabnormalitiesinducedbyabarteetherondevelopingchickembryo AT ramkumarashoka morphologicalandskeletalabnormalitiesinducedbyabarteetherondevelopingchickembryo |