Gene co-expression networks are associated with obesity-related traits in kidney transplant recipients
Abstract Background Obesity is common among kidney transplant recipients; However biological mediators of obesity are not well understood in this population. Because subcutaneous adipose tissue can be easily obtained during kidney transplant surgery, it provides a unique avenue for studying the mech...
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| Format: | Article |
| Language: | English |
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BMC
2020-03-01
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| Series: | BMC Medical Genomics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12920-020-0702-5 |
| _version_ | 1818325027430334464 |
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| author | Rosario B. Jaime-Lara Abhrarup Roy Yupeng Wang Ansley Stanfill Ann K. Cashion Paule V. Joseph |
| author_facet | Rosario B. Jaime-Lara Abhrarup Roy Yupeng Wang Ansley Stanfill Ann K. Cashion Paule V. Joseph |
| author_sort | Rosario B. Jaime-Lara |
| collection | DOAJ |
| description | Abstract Background Obesity is common among kidney transplant recipients; However biological mediators of obesity are not well understood in this population. Because subcutaneous adipose tissue can be easily obtained during kidney transplant surgery, it provides a unique avenue for studying the mechanisms of obesity for this group. Although differential gene expression patterns were previously profiled for kidney transplant patients, gene co-expression patterns can shed light on gene modules not yet explored on the coordinative behaviors of gene transcription in biological and disease processes from a systems perspective. Methods In this study, we collected 29 demographic and clinical variables and matching microarray expression data for 26 kidney transplant patients. We conducted Weighted Gene Correlation Network Analysis (WGCNA) for 5758 genes with the highest average expression levels and related gene co-expression to clinical traits. Results A total of 35 co-expression modules were detected, two of which showed associations with obesity-related traits, mainly at baseline. Gene Ontology (GO) enrichment was found for these two clinical trait-associated modules. One module consisting of 129 genes was enriched for a variety of processes, including cellular homeostasis and immune responses. The other module consisting of 36 genes was enriched for tissue development processes. Conclusions Our study generated gene co-expression modules associated with obesity-related traits in kidney transplant patients and provided new insights regarding the cellular biological processes underlying obesity in this population. |
| first_indexed | 2024-12-13T11:37:57Z |
| format | Article |
| id | doaj.art-37dee2472e1f4f92a932f424cb26e1b4 |
| institution | Directory Open Access Journal |
| issn | 1755-8794 |
| language | English |
| last_indexed | 2024-12-13T11:37:57Z |
| publishDate | 2020-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genomics |
| spelling | doaj.art-37dee2472e1f4f92a932f424cb26e1b42022-12-21T23:47:43ZengBMCBMC Medical Genomics1755-87942020-03-0113111210.1186/s12920-020-0702-5Gene co-expression networks are associated with obesity-related traits in kidney transplant recipientsRosario B. Jaime-Lara0Abhrarup Roy1Yupeng Wang2Ansley Stanfill3Ann K. Cashion4Paule V. Joseph5Division of Intramural Research, National Institute of Nursing Research, National Institutes of HealthDivision of Intramural Research, National Institute of Nursing Research, National Institutes of HealthBDX Research & Consulting LLCThe University of Tennessee Health Science Center, College of Nursing, MemphisDivision of Intramural Research, National Institute of Nursing Research, National Institutes of HealthDivision of Intramural Research, National Institute of Nursing Research, National Institutes of HealthAbstract Background Obesity is common among kidney transplant recipients; However biological mediators of obesity are not well understood in this population. Because subcutaneous adipose tissue can be easily obtained during kidney transplant surgery, it provides a unique avenue for studying the mechanisms of obesity for this group. Although differential gene expression patterns were previously profiled for kidney transplant patients, gene co-expression patterns can shed light on gene modules not yet explored on the coordinative behaviors of gene transcription in biological and disease processes from a systems perspective. Methods In this study, we collected 29 demographic and clinical variables and matching microarray expression data for 26 kidney transplant patients. We conducted Weighted Gene Correlation Network Analysis (WGCNA) for 5758 genes with the highest average expression levels and related gene co-expression to clinical traits. Results A total of 35 co-expression modules were detected, two of which showed associations with obesity-related traits, mainly at baseline. Gene Ontology (GO) enrichment was found for these two clinical trait-associated modules. One module consisting of 129 genes was enriched for a variety of processes, including cellular homeostasis and immune responses. The other module consisting of 36 genes was enriched for tissue development processes. Conclusions Our study generated gene co-expression modules associated with obesity-related traits in kidney transplant patients and provided new insights regarding the cellular biological processes underlying obesity in this population.http://link.springer.com/article/10.1186/s12920-020-0702-5Co-expression modulesObesityAssociationEnrichment analysisGene ontologyKidney transplant |
| spellingShingle | Rosario B. Jaime-Lara Abhrarup Roy Yupeng Wang Ansley Stanfill Ann K. Cashion Paule V. Joseph Gene co-expression networks are associated with obesity-related traits in kidney transplant recipients BMC Medical Genomics Co-expression modules Obesity Association Enrichment analysis Gene ontology Kidney transplant |
| title | Gene co-expression networks are associated with obesity-related traits in kidney transplant recipients |
| title_full | Gene co-expression networks are associated with obesity-related traits in kidney transplant recipients |
| title_fullStr | Gene co-expression networks are associated with obesity-related traits in kidney transplant recipients |
| title_full_unstemmed | Gene co-expression networks are associated with obesity-related traits in kidney transplant recipients |
| title_short | Gene co-expression networks are associated with obesity-related traits in kidney transplant recipients |
| title_sort | gene co expression networks are associated with obesity related traits in kidney transplant recipients |
| topic | Co-expression modules Obesity Association Enrichment analysis Gene ontology Kidney transplant |
| url | http://link.springer.com/article/10.1186/s12920-020-0702-5 |
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