Development of a Risk Predictive Scoring System for Epilepsy in Infants with Paroxysmal Motor Events: A Retrospective Single-Center Study
Purpose Paroxysmal motor events are common clinical symptoms in infants visiting pediatric neurology clinics. Due to the heterogeneous clinical symptoms and the difficulty of interpreting electroencephalography (EEG) in infants, differentiating paroxysmal motor events from epileptic events is challe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Korean Child Neurology Society
2022-01-01
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| Series: | Annals of Child Neurology |
| Subjects: | |
| Online Access: | http://www.annchildneurol.org/upload/pdf/acn-2021-00514.pdf |
| _version_ | 1818943115798511616 |
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| author | Han Jun Kim Han Na Jang Hyunji Ahn Mi-Sun Yum Tae-Sung Ko |
| author_facet | Han Jun Kim Han Na Jang Hyunji Ahn Mi-Sun Yum Tae-Sung Ko |
| author_sort | Han Jun Kim |
| collection | DOAJ |
| description | Purpose Paroxysmal motor events are common clinical symptoms in infants visiting pediatric neurology clinics. Due to the heterogeneous clinical symptoms and the difficulty of interpreting electroencephalography (EEG) in infants, differentiating paroxysmal motor events from epileptic events is challenging. This study aimed to investigate the risk factors for the diagnosis of epilepsy in infants and to develop a scoring system that predicts the risk of epilepsy. Methods We retrospectively analyzed data from patients who presented with paroxysmal motor events in infancy between January 2008 and December 2009 at Asan Medical Center. Electronic medical records were reviewed for patients’ demographics, medical history, clinical characteristics associated with specific situations, and motor symptoms. Laboratory findings, EEG, and brain magnetic resonance imaging were also reviewed. Results In total, 111 infants with paroxysmal motor events were enrolled. Non-epileptic paroxysmal motor events (NEPMs) were associated with specific situations (P<0.001). Patients with epilepsy were likely to have focal motor symptoms (P=0.08), a medical history of a neurologic disorder, and/or a family history of epilepsy (P<0.05). A risk scoring system was developed based on these risk factors; using this system, infants with 2 or more points could be diagnosed with epilepsy with 61.76% sensitivity and 88.31% specificity. Conclusion Infants with paroxysmal motor events were more likely to be diagnosed with NEPMs than with epilepsy. An absence of specific situations for paroxysmal events, focal motor seizures, and a medical history of another illness were associated with the final diagnosis of epilepsy. |
| first_indexed | 2024-12-20T07:22:12Z |
| format | Article |
| id | doaj.art-37df90fb357d4ac3978cfbaa5aab7d99 |
| institution | Directory Open Access Journal |
| issn | 2635-909X 2635-9103 |
| language | English |
| last_indexed | 2024-12-20T07:22:12Z |
| publishDate | 2022-01-01 |
| publisher | Korean Child Neurology Society |
| record_format | Article |
| series | Annals of Child Neurology |
| spelling | doaj.art-37df90fb357d4ac3978cfbaa5aab7d992022-12-21T19:48:39ZengKorean Child Neurology SocietyAnnals of Child Neurology2635-909X2635-91032022-01-013011710.26815/acn.2021.005141257Development of a Risk Predictive Scoring System for Epilepsy in Infants with Paroxysmal Motor Events: A Retrospective Single-Center StudyHan Jun Kim0Han Na Jang1Hyunji Ahn2Mi-Sun Yum3Tae-Sung Ko4 Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul, Korea Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul, Korea Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul, Korea Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul, Korea Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul, KoreaPurpose Paroxysmal motor events are common clinical symptoms in infants visiting pediatric neurology clinics. Due to the heterogeneous clinical symptoms and the difficulty of interpreting electroencephalography (EEG) in infants, differentiating paroxysmal motor events from epileptic events is challenging. This study aimed to investigate the risk factors for the diagnosis of epilepsy in infants and to develop a scoring system that predicts the risk of epilepsy. Methods We retrospectively analyzed data from patients who presented with paroxysmal motor events in infancy between January 2008 and December 2009 at Asan Medical Center. Electronic medical records were reviewed for patients’ demographics, medical history, clinical characteristics associated with specific situations, and motor symptoms. Laboratory findings, EEG, and brain magnetic resonance imaging were also reviewed. Results In total, 111 infants with paroxysmal motor events were enrolled. Non-epileptic paroxysmal motor events (NEPMs) were associated with specific situations (P<0.001). Patients with epilepsy were likely to have focal motor symptoms (P=0.08), a medical history of a neurologic disorder, and/or a family history of epilepsy (P<0.05). A risk scoring system was developed based on these risk factors; using this system, infants with 2 or more points could be diagnosed with epilepsy with 61.76% sensitivity and 88.31% specificity. Conclusion Infants with paroxysmal motor events were more likely to be diagnosed with NEPMs than with epilepsy. An absence of specific situations for paroxysmal events, focal motor seizures, and a medical history of another illness were associated with the final diagnosis of epilepsy.http://www.annchildneurol.org/upload/pdf/acn-2021-00514.pdfseizuresepilepsyinfantrisk factors |
| spellingShingle | Han Jun Kim Han Na Jang Hyunji Ahn Mi-Sun Yum Tae-Sung Ko Development of a Risk Predictive Scoring System for Epilepsy in Infants with Paroxysmal Motor Events: A Retrospective Single-Center Study Annals of Child Neurology seizures epilepsy infant risk factors |
| title | Development of a Risk Predictive Scoring System for Epilepsy in Infants with Paroxysmal Motor Events: A Retrospective Single-Center Study |
| title_full | Development of a Risk Predictive Scoring System for Epilepsy in Infants with Paroxysmal Motor Events: A Retrospective Single-Center Study |
| title_fullStr | Development of a Risk Predictive Scoring System for Epilepsy in Infants with Paroxysmal Motor Events: A Retrospective Single-Center Study |
| title_full_unstemmed | Development of a Risk Predictive Scoring System for Epilepsy in Infants with Paroxysmal Motor Events: A Retrospective Single-Center Study |
| title_short | Development of a Risk Predictive Scoring System for Epilepsy in Infants with Paroxysmal Motor Events: A Retrospective Single-Center Study |
| title_sort | development of a risk predictive scoring system for epilepsy in infants with paroxysmal motor events a retrospective single center study |
| topic | seizures epilepsy infant risk factors |
| url | http://www.annchildneurol.org/upload/pdf/acn-2021-00514.pdf |
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