Subcellular localization of hexadecanedioic acid activation in human liver
The activation of hexadecanedioic acid has been studied in subcellular fractions of human liver. The activation capacity in a total homogenate of human liver was found to be 0.5 μmole/min/g wet wt of tissue, about 10% of that for palmitic acid. Hexadecanedioic acid was activated by the mitochondrial...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
1974-11-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520367559 |
| _version_ | 1823929912556257280 |
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| author | Jon Elling Pettersen Magne Aas |
| author_facet | Jon Elling Pettersen Magne Aas |
| author_sort | Jon Elling Pettersen |
| collection | DOAJ |
| description | The activation of hexadecanedioic acid has been studied in subcellular fractions of human liver. The activation capacity in a total homogenate of human liver was found to be 0.5 μmole/min/g wet wt of tissue, about 10% of that for palmitic acid. Hexadecanedioic acid was activated by the mitochondrial and microsomal fractions. The mitochondrial enzyme is probably localized outside the inner mitochondrial compartment. The subcellular distribution of the hexadecanedioic acid activation was almost identical with the distribution of palmitic acid activation. Hexadecanedioic and palmitic acids seemed to compete for the same enzyme. |
| first_indexed | 2024-12-16T21:15:59Z |
| format | Article |
| id | doaj.art-37dfd0c6efab47b08710a452ec53a472 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-16T21:15:59Z |
| publishDate | 1974-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-37dfd0c6efab47b08710a452ec53a4722022-12-21T22:16:02ZengElsevierJournal of Lipid Research0022-22751974-11-01156551556Subcellular localization of hexadecanedioic acid activation in human liverJon Elling Pettersen0Magne Aas1Institute of Clinical Biochemistry, University of Oslo, Rikshospitalet, Oslo, NorwayInstitute of Clinical Biochemistry, University of Oslo, Rikshospitalet, Oslo, NorwayThe activation of hexadecanedioic acid has been studied in subcellular fractions of human liver. The activation capacity in a total homogenate of human liver was found to be 0.5 μmole/min/g wet wt of tissue, about 10% of that for palmitic acid. Hexadecanedioic acid was activated by the mitochondrial and microsomal fractions. The mitochondrial enzyme is probably localized outside the inner mitochondrial compartment. The subcellular distribution of the hexadecanedioic acid activation was almost identical with the distribution of palmitic acid activation. Hexadecanedioic and palmitic acids seemed to compete for the same enzyme.http://www.sciencedirect.com/science/article/pii/S0022227520367559acyl CoA synthetasehexadecanoyl CoA:carnitine O-hexadecanoyltransferasetissue fractionation |
| spellingShingle | Jon Elling Pettersen Magne Aas Subcellular localization of hexadecanedioic acid activation in human liver Journal of Lipid Research acyl CoA synthetase hexadecanoyl CoA:carnitine O-hexadecanoyltransferase tissue fractionation |
| title | Subcellular localization of hexadecanedioic acid activation in human liver |
| title_full | Subcellular localization of hexadecanedioic acid activation in human liver |
| title_fullStr | Subcellular localization of hexadecanedioic acid activation in human liver |
| title_full_unstemmed | Subcellular localization of hexadecanedioic acid activation in human liver |
| title_short | Subcellular localization of hexadecanedioic acid activation in human liver |
| title_sort | subcellular localization of hexadecanedioic acid activation in human liver |
| topic | acyl CoA synthetase hexadecanoyl CoA:carnitine O-hexadecanoyltransferase tissue fractionation |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520367559 |
| work_keys_str_mv | AT jonellingpettersen subcellularlocalizationofhexadecanedioicacidactivationinhumanliver AT magneaas subcellularlocalizationofhexadecanedioicacidactivationinhumanliver |