Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma
Abstract Background Intractable nasopharyngeal hemorrhage is a severe complication with high mortality rate in patients with radiation therapy (RT) for nasopharyngeal carcinoma (NPC) that requires emergency treatment. Quite a few of them combine with tumor recurrence. Treatment planning for these pa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-10-01
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| Series: | Cancer Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cnr2.1671 |
| _version_ | 1828344101744934912 |
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| author | Bao‐Feng Duan Hua‐Ying Chen Xue‐Mei Zheng Qing He |
| author_facet | Bao‐Feng Duan Hua‐Ying Chen Xue‐Mei Zheng Qing He |
| author_sort | Bao‐Feng Duan |
| collection | DOAJ |
| description | Abstract Background Intractable nasopharyngeal hemorrhage is a severe complication with high mortality rate in patients with radiation therapy (RT) for nasopharyngeal carcinoma (NPC) that requires emergency treatment. Quite a few of them combine with tumor recurrence. Treatment planning for these patients is extremely difficult for oncologists, and effective treatments are lacking. Case A 42‐year‐old man had a history of recurrent NPC that was treated with 2 cycles of chemoradiotherapies from 2017 to 2019. Five months after the second round of chemoradiotherapy, an episode of massive nasal bleeding occurred. As positron emission tomography (PET) scan revealed tumor recurrence in the left wall of nasopharynx, superselective embolization and subsequent intra‐arterial infusion (IA, 4 times of cisplatin 60 mg + fluorouracil 1.0 g) were performed to stop bleeding and achieve tumor control. To date, the disease‐free survival time has been over 1 year. No tumor recurrence or rebleeding is found except for alopecia on the left side. Conclusions Interventional radiology is important and effective in the treatment of recurrent NPC for both massive nasal bleeding and tumor control. However, the unique complication of unilateral alopecia should not be ignored. |
| first_indexed | 2024-04-13T23:52:32Z |
| format | Article |
| id | doaj.art-37e0733d8ec346f595479d0c23aedc84 |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-04-13T23:52:32Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-37e0733d8ec346f595479d0c23aedc842022-12-22T02:24:01ZengWileyCancer Reports2573-83482022-10-01510n/an/a10.1002/cnr2.1671Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinomaBao‐Feng Duan0Hua‐Ying Chen1Xue‐Mei Zheng2Qing He3Department of Head and Neck Oncology West China Hospital of Sichuan University Chengdu Sichuan Province ChinaDepartment of Head and Neck Oncology West China Hospital of Sichuan University Chengdu Sichuan Province ChinaDepartment of Head and Neck Oncology West China Hospital of Sichuan University Chengdu Sichuan Province ChinaDepartment of Head and Neck Oncology West China Hospital of Sichuan University Chengdu Sichuan Province ChinaAbstract Background Intractable nasopharyngeal hemorrhage is a severe complication with high mortality rate in patients with radiation therapy (RT) for nasopharyngeal carcinoma (NPC) that requires emergency treatment. Quite a few of them combine with tumor recurrence. Treatment planning for these patients is extremely difficult for oncologists, and effective treatments are lacking. Case A 42‐year‐old man had a history of recurrent NPC that was treated with 2 cycles of chemoradiotherapies from 2017 to 2019. Five months after the second round of chemoradiotherapy, an episode of massive nasal bleeding occurred. As positron emission tomography (PET) scan revealed tumor recurrence in the left wall of nasopharynx, superselective embolization and subsequent intra‐arterial infusion (IA, 4 times of cisplatin 60 mg + fluorouracil 1.0 g) were performed to stop bleeding and achieve tumor control. To date, the disease‐free survival time has been over 1 year. No tumor recurrence or rebleeding is found except for alopecia on the left side. Conclusions Interventional radiology is important and effective in the treatment of recurrent NPC for both massive nasal bleeding and tumor control. However, the unique complication of unilateral alopecia should not be ignored.https://doi.org/10.1002/cnr2.1671adverse effectsalopeciainterventional radiologynasopharyngeal carcinomaradiation therapy |
| spellingShingle | Bao‐Feng Duan Hua‐Ying Chen Xue‐Mei Zheng Qing He Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma Cancer Reports adverse effects alopecia interventional radiology nasopharyngeal carcinoma radiation therapy |
| title | Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma |
| title_full | Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma |
| title_fullStr | Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma |
| title_full_unstemmed | Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma |
| title_short | Acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma |
| title_sort | acquired unilateral alopecia after arterial infusion chemotherapy in a recurrent nasopharyngeal carcinoma |
| topic | adverse effects alopecia interventional radiology nasopharyngeal carcinoma radiation therapy |
| url | https://doi.org/10.1002/cnr2.1671 |
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