A Retrospective Multicenter Study of Risk Factors, Stratification, and Prognosis of Lymph Node Metastasis in T1 and T2 Colorectal Cancer
Background. The objective of this study was to compare the long-term prognosis of patients with T1 and T2 colorectal cancer (CRC) according to lymph node metastasis (LNM) and to identify risk factors for LNM. Methods. We retrospectively reviewed patients who underwent curative resection for T1 or T2...
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MDPI AG
2023-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/24/7744 |
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| author | Eui Myung Kim Il Tae Son Byung Chun Kim Jun Ho Park Byung Mo Kang Jong Wan Kim |
| author_facet | Eui Myung Kim Il Tae Son Byung Chun Kim Jun Ho Park Byung Mo Kang Jong Wan Kim |
| author_sort | Eui Myung Kim |
| collection | DOAJ |
| description | Background. The objective of this study was to compare the long-term prognosis of patients with T1 and T2 colorectal cancer (CRC) according to lymph node metastasis (LNM) and to identify risk factors for LNM. Methods. We retrospectively reviewed patients who underwent curative resection for T1 or T2 CRC at five University-affiliated hospitals between January 2012 and December 2021. The patients were divided into several groups depending on the presence of LNM or the number of risk factors. Results. Of the total 765 patients, 87 (11.3%) patients had LNM. These patients had poorer recurrence-free survival (RFS) than patients without LNM (72.6% vs. 88.6%). The multivariable analysis showed that high-grade tumors (<i>p</i> = 0.003), lymphovascular invasion (<i>p</i> < 0.001), and rectal location (<i>p</i> = 0.049) were independent predictors of LNM. When divided into groups according to the number of the three risk factors, the risk of LNM increased from 5.4% (ultralow-risk group; no risk factor) to 60.0% (high-risk group; all three risk factors) and the 5-year RFS rate decreased from 96.3% in the ultralow-risk group to 60% in the high-risk group (<i>p</i> < 0.001). Conclusion. Radical surgery should be considered for T1 and T2 CRC patients with these risk factors. |
| first_indexed | 2024-03-08T20:38:40Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T20:38:40Z |
| publishDate | 2023-12-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-37e0aa68eea0432ab014655fd89a22f52023-12-22T14:17:38ZengMDPI AGJournal of Clinical Medicine2077-03832023-12-011224774410.3390/jcm12247744A Retrospective Multicenter Study of Risk Factors, Stratification, and Prognosis of Lymph Node Metastasis in T1 and T2 Colorectal CancerEui Myung Kim0Il Tae Son1Byung Chun Kim2Jun Ho Park3Byung Mo Kang4Jong Wan Kim5Department of Surgery, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, 40, Sukwoo-Dong, Hwaseong-si 445-170, Republic of KoreaDepartment of Surgery, Hallym Sacred Heart Hospital, Hallym University College of Medicine, Anyang-si 445-907, Republic of KoreaDepartment of Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, 948-1, 1, Shingil-ro, Yeongdeungpo-gu, Seoul 150-950, Republic of KoreaDepartment of Surgery, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, 445 Gil-1-dong, Gangdong-gu, Seoul 134-701, Republic of KoreaDepartment of Surgery, Chun Cheon Sacred Heart Hospital, Hallym University College of Medicine, 77 Sakju-ro, Chuncheon-si 200-130, Republic of KoreaDepartment of Surgery, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, 40, Sukwoo-Dong, Hwaseong-si 445-170, Republic of KoreaBackground. The objective of this study was to compare the long-term prognosis of patients with T1 and T2 colorectal cancer (CRC) according to lymph node metastasis (LNM) and to identify risk factors for LNM. Methods. We retrospectively reviewed patients who underwent curative resection for T1 or T2 CRC at five University-affiliated hospitals between January 2012 and December 2021. The patients were divided into several groups depending on the presence of LNM or the number of risk factors. Results. Of the total 765 patients, 87 (11.3%) patients had LNM. These patients had poorer recurrence-free survival (RFS) than patients without LNM (72.6% vs. 88.6%). The multivariable analysis showed that high-grade tumors (<i>p</i> = 0.003), lymphovascular invasion (<i>p</i> < 0.001), and rectal location (<i>p</i> = 0.049) were independent predictors of LNM. When divided into groups according to the number of the three risk factors, the risk of LNM increased from 5.4% (ultralow-risk group; no risk factor) to 60.0% (high-risk group; all three risk factors) and the 5-year RFS rate decreased from 96.3% in the ultralow-risk group to 60% in the high-risk group (<i>p</i> < 0.001). Conclusion. Radical surgery should be considered for T1 and T2 CRC patients with these risk factors.https://www.mdpi.com/2077-0383/12/24/7744colorectal cancerlymph node metastasisrisk factor |
| spellingShingle | Eui Myung Kim Il Tae Son Byung Chun Kim Jun Ho Park Byung Mo Kang Jong Wan Kim A Retrospective Multicenter Study of Risk Factors, Stratification, and Prognosis of Lymph Node Metastasis in T1 and T2 Colorectal Cancer Journal of Clinical Medicine colorectal cancer lymph node metastasis risk factor |
| title | A Retrospective Multicenter Study of Risk Factors, Stratification, and Prognosis of Lymph Node Metastasis in T1 and T2 Colorectal Cancer |
| title_full | A Retrospective Multicenter Study of Risk Factors, Stratification, and Prognosis of Lymph Node Metastasis in T1 and T2 Colorectal Cancer |
| title_fullStr | A Retrospective Multicenter Study of Risk Factors, Stratification, and Prognosis of Lymph Node Metastasis in T1 and T2 Colorectal Cancer |
| title_full_unstemmed | A Retrospective Multicenter Study of Risk Factors, Stratification, and Prognosis of Lymph Node Metastasis in T1 and T2 Colorectal Cancer |
| title_short | A Retrospective Multicenter Study of Risk Factors, Stratification, and Prognosis of Lymph Node Metastasis in T1 and T2 Colorectal Cancer |
| title_sort | retrospective multicenter study of risk factors stratification and prognosis of lymph node metastasis in t1 and t2 colorectal cancer |
| topic | colorectal cancer lymph node metastasis risk factor |
| url | https://www.mdpi.com/2077-0383/12/24/7744 |
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