Emergence of t(3;21)(q26.2;q22) during eltrombopag treatment in a patient with relapsed aplastic anemia who received chemotherapy for angioimmunoblastic T-cell lymphoma
A 65-year-old man with nonsevere aplastic anemia received rabbit anti-thymocyte globulin and cyclosporine and partially responded. Six months after the initiation of treatment, he was diagnosed with stage IV angioimmunoblastic T-cell lymphoma and received chemotherapy. PET/CT scan analysis indicated...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Leukemia Research Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048922000176 |
| _version_ | 1818524076215369728 |
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| author | Fumi Nakamura Yuka Nakamura Yasuhito Nannya Honoka Arai Kei Shimbo Yuko Nakamura Sachiko Seo Ko Sasaki Motoshi Ichikawa Seishi Ogawa Kinuko Mitani |
| author_facet | Fumi Nakamura Yuka Nakamura Yasuhito Nannya Honoka Arai Kei Shimbo Yuko Nakamura Sachiko Seo Ko Sasaki Motoshi Ichikawa Seishi Ogawa Kinuko Mitani |
| author_sort | Fumi Nakamura |
| collection | DOAJ |
| description | A 65-year-old man with nonsevere aplastic anemia received rabbit anti-thymocyte globulin and cyclosporine and partially responded. Six months after the initiation of treatment, he was diagnosed with stage IV angioimmunoblastic T-cell lymphoma and received chemotherapy. PET/CT scan analysis indicated a complete response. However, he showed sustained myelosuppression and was diagnosed with relapse of aplastic anemia. He did not respond to cyclosporine, eltrombopag or methenolone. Fifteen months after eltrombopag administration, he developed MDS with t(3;21)(q26.2;q22). Patients should be monitored carefully for the emergence of not only -7/del(7q) but also 3q26 abnormalities, including t(3;21)(q26.2;q22), during and after eltrombopag treatment. |
| first_indexed | 2024-12-11T05:52:43Z |
| format | Article |
| id | doaj.art-37e5fec8857a4c55b385f8ab4c429d24 |
| institution | Directory Open Access Journal |
| issn | 2213-0489 |
| language | English |
| last_indexed | 2024-12-11T05:52:43Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj.art-37e5fec8857a4c55b385f8ab4c429d242022-12-22T01:18:46ZengElsevierLeukemia Research Reports2213-04892022-01-0117100305Emergence of t(3;21)(q26.2;q22) during eltrombopag treatment in a patient with relapsed aplastic anemia who received chemotherapy for angioimmunoblastic T-cell lymphomaFumi Nakamura0Yuka Nakamura1Yasuhito Nannya2Honoka Arai3Kei Shimbo4Yuko Nakamura5Sachiko Seo6Ko Sasaki7Motoshi Ichikawa8Seishi Ogawa9Kinuko Mitani10Department of Hematology and Oncology, Dokkyo Medical University, Tochigi, 321-0293, JapanDepartment of Hematology and Oncology, Dokkyo Medical University, Tochigi, 321-0293, JapanDepartment of Pathology and Tumor Biology, Kyoto University, Kyoto, JapanDepartment of Hematology and Oncology, Dokkyo Medical University, Tochigi, 321-0293, JapanClinical Laboratory Center, Dokkyo Medical University Hospital, Tochigi, JapanDepartment of Hematology and Oncology, Dokkyo Medical University, Tochigi, 321-0293, JapanDepartment of Hematology and Oncology, Dokkyo Medical University, Tochigi, 321-0293, JapanDepartment of Hematology and Oncology, Dokkyo Medical University, Tochigi, 321-0293, JapanDepartment of Hematology and Oncology, Dokkyo Medical University, Tochigi, 321-0293, JapanDepartment of Pathology and Tumor Biology, Kyoto University, Kyoto, JapanDepartment of Hematology and Oncology, Dokkyo Medical University, Tochigi, 321-0293, Japan; Corresponding author.A 65-year-old man with nonsevere aplastic anemia received rabbit anti-thymocyte globulin and cyclosporine and partially responded. Six months after the initiation of treatment, he was diagnosed with stage IV angioimmunoblastic T-cell lymphoma and received chemotherapy. PET/CT scan analysis indicated a complete response. However, he showed sustained myelosuppression and was diagnosed with relapse of aplastic anemia. He did not respond to cyclosporine, eltrombopag or methenolone. Fifteen months after eltrombopag administration, he developed MDS with t(3;21)(q26.2;q22). Patients should be monitored carefully for the emergence of not only -7/del(7q) but also 3q26 abnormalities, including t(3;21)(q26.2;q22), during and after eltrombopag treatment.http://www.sciencedirect.com/science/article/pii/S2213048922000176EltrombopagAplastic anemiaMyelodysplastic syndromesAngioimmunoblastic t-cell lymphoma3q26 abnormalities |
| spellingShingle | Fumi Nakamura Yuka Nakamura Yasuhito Nannya Honoka Arai Kei Shimbo Yuko Nakamura Sachiko Seo Ko Sasaki Motoshi Ichikawa Seishi Ogawa Kinuko Mitani Emergence of t(3;21)(q26.2;q22) during eltrombopag treatment in a patient with relapsed aplastic anemia who received chemotherapy for angioimmunoblastic T-cell lymphoma Leukemia Research Reports Eltrombopag Aplastic anemia Myelodysplastic syndromes Angioimmunoblastic t-cell lymphoma 3q26 abnormalities |
| title | Emergence of t(3;21)(q26.2;q22) during eltrombopag treatment in a patient with relapsed aplastic anemia who received chemotherapy for angioimmunoblastic T-cell lymphoma |
| title_full | Emergence of t(3;21)(q26.2;q22) during eltrombopag treatment in a patient with relapsed aplastic anemia who received chemotherapy for angioimmunoblastic T-cell lymphoma |
| title_fullStr | Emergence of t(3;21)(q26.2;q22) during eltrombopag treatment in a patient with relapsed aplastic anemia who received chemotherapy for angioimmunoblastic T-cell lymphoma |
| title_full_unstemmed | Emergence of t(3;21)(q26.2;q22) during eltrombopag treatment in a patient with relapsed aplastic anemia who received chemotherapy for angioimmunoblastic T-cell lymphoma |
| title_short | Emergence of t(3;21)(q26.2;q22) during eltrombopag treatment in a patient with relapsed aplastic anemia who received chemotherapy for angioimmunoblastic T-cell lymphoma |
| title_sort | emergence of t 3 21 q26 2 q22 during eltrombopag treatment in a patient with relapsed aplastic anemia who received chemotherapy for angioimmunoblastic t cell lymphoma |
| topic | Eltrombopag Aplastic anemia Myelodysplastic syndromes Angioimmunoblastic t-cell lymphoma 3q26 abnormalities |
| url | http://www.sciencedirect.com/science/article/pii/S2213048922000176 |
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