Robust method of estimating of odd ratios in case-control association studies
In case-control studies, association of a disease with a genetic trait can be studied in terms of Single Nucleotide Polymorphisms (SNP). Prospective and retrospective likelihoods are the two common approaches used to study this association. In this paper, a method based on Preliminary test, has bee...
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| Format: | Article |
| Language: | English |
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Indian Council of Agricultural Research
2020-06-01
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| Series: | The Indian Journal of Agricultural Sciences |
| Subjects: | |
| Online Access: | https://epubs.icar.org.in/index.php/IJAgS/article/view/101496 |
| _version_ | 1811164697287720960 |
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| author | Manju Mary Paul Anil Rai |
| author_facet | Manju Mary Paul Anil Rai |
| author_sort | Manju Mary Paul |
| collection | DOAJ |
| description |
In case-control studies, association of a disease with a genetic trait can be studied in terms of Single Nucleotide Polymorphisms (SNP). Prospective and retrospective likelihoods are the two common approaches used to study this association. In this paper, a method based on Preliminary test, has been proposed, which is efficient than prospective approach by exploiting model assumptions of Hardy Weinberg Equilibrium (HWE) and robust against failure of model assumptions as compared to retrospective approach (2015-16). In this proposed approach, a Preliminary Test Estimator (PTE) has been suggested based on both prospective and retrospective approach for estimating of association of a disease with genetic marker. The proposed PTE has been empirically evaluated through a simulation study. The Preliminary Test Estimator developed was found to be robust against the deviation from HWE.
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| first_indexed | 2024-04-10T15:25:40Z |
| format | Article |
| id | doaj.art-37e60a2a776449af9145413e44b1b24f |
| institution | Directory Open Access Journal |
| issn | 0019-5022 2394-3319 |
| language | English |
| last_indexed | 2024-04-10T15:25:40Z |
| publishDate | 2020-06-01 |
| publisher | Indian Council of Agricultural Research |
| record_format | Article |
| series | The Indian Journal of Agricultural Sciences |
| spelling | doaj.art-37e60a2a776449af9145413e44b1b24f2023-02-14T09:10:13ZengIndian Council of Agricultural ResearchThe Indian Journal of Agricultural Sciences0019-50222394-33192020-06-0190310.56093/ijas.v90i3.101496Robust method of estimating of odd ratios in case-control association studiesManju Mary Paul0Anil Rai1ICAR-Indian Agricultural Statistics Research Institute, New Delhi 110 012, IndiaICAR-Indian Agricultural Statistics Research Institute, New Delhi 110 012, India In case-control studies, association of a disease with a genetic trait can be studied in terms of Single Nucleotide Polymorphisms (SNP). Prospective and retrospective likelihoods are the two common approaches used to study this association. In this paper, a method based on Preliminary test, has been proposed, which is efficient than prospective approach by exploiting model assumptions of Hardy Weinberg Equilibrium (HWE) and robust against failure of model assumptions as compared to retrospective approach (2015-16). In this proposed approach, a Preliminary Test Estimator (PTE) has been suggested based on both prospective and retrospective approach for estimating of association of a disease with genetic marker. The proposed PTE has been empirically evaluated through a simulation study. The Preliminary Test Estimator developed was found to be robust against the deviation from HWE. https://epubs.icar.org.in/index.php/IJAgS/article/view/101496Case-Control StudyPreliminary Test EstimatorProspective ApproachRetrospective ApproachSingle Nucleotide Polymorphisms |
| spellingShingle | Manju Mary Paul Anil Rai Robust method of estimating of odd ratios in case-control association studies The Indian Journal of Agricultural Sciences Case-Control Study Preliminary Test Estimator Prospective Approach Retrospective Approach Single Nucleotide Polymorphisms |
| title | Robust method of estimating of odd ratios in case-control association studies |
| title_full | Robust method of estimating of odd ratios in case-control association studies |
| title_fullStr | Robust method of estimating of odd ratios in case-control association studies |
| title_full_unstemmed | Robust method of estimating of odd ratios in case-control association studies |
| title_short | Robust method of estimating of odd ratios in case-control association studies |
| title_sort | robust method of estimating of odd ratios in case control association studies |
| topic | Case-Control Study Preliminary Test Estimator Prospective Approach Retrospective Approach Single Nucleotide Polymorphisms |
| url | https://epubs.icar.org.in/index.php/IJAgS/article/view/101496 |
| work_keys_str_mv | AT manjumarypaul robustmethodofestimatingofoddratiosincasecontrolassociationstudies AT anilrai robustmethodofestimatingofoddratiosincasecontrolassociationstudies |