Efficacy and safety of acitretin monotherapy in children with pustular psoriasis: results from 15 cases and a literature review
Background: There is a few evidence-based information regarding the efficacy and safety of acitretin treatment in children with pustular psoriasis (PP). Objective: This study aimed to provide an additional evidence for this field. Methods: A retrospective study was undertaken for 15 children with PP...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-05-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2017.1395798 |
| _version_ | 1797683729305436160 |
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| author | Pingjiao Chen Changxing Li Rujun Xue Huiheng Chen Xin Tian Kang Zeng Xibao Zhang Jingyao Liang |
| author_facet | Pingjiao Chen Changxing Li Rujun Xue Huiheng Chen Xin Tian Kang Zeng Xibao Zhang Jingyao Liang |
| author_sort | Pingjiao Chen |
| collection | DOAJ |
| description | Background: There is a few evidence-based information regarding the efficacy and safety of acitretin treatment in children with pustular psoriasis (PP). Objective: This study aimed to provide an additional evidence for this field. Methods: A retrospective study was undertaken for 15 children with PP who received acitretin in doses of 0.6–1.0 mg/kg/day for 4–6 weeks, the transition dose of 0.2–0.4 mg/kg/day for 4–6 weeks and maintenance dose of 0.2–0.3 mg/kg/day. Additionally, a literature review on this topic is conducted. Results: Of 15 children with generalized PP (GPP, n = 10), palmoplantar psoriasis (PPP, n = 3), and acrodermatitis continua of Hallopeau (ACH, n = 2), 93.3% (14/15) showed good response, only one case with ACH exhibited moderate response. During the 10–32 months of follow-up, acitrerin monotherapy for children cases with PP overall showed good efficacy and safety. In the literature review, a total of 107 childhood PP cases treated with acitretin in 21 studies were included in the analysis. The clinical effectiveness was obtained in 88.8% (95/107) patients treated with acitretin as monotherapy or combination therapy, and most of cases (92.6%, 100/107) treated by acitretin did not report side effects during the treatment and follow-up of acitretin. Limitation: This study is just included a small sample sizes and no standardized studies were used in the literature. Conclusion: Acitretin therapy for children with PP (monotherapy or combination therapy), all showed a satisfactory therapeutic effect and safety, independent of the short or long-tern therapeutic procedures. |
| first_indexed | 2024-03-12T00:18:59Z |
| format | Article |
| id | doaj.art-37e699a318984ab4be1c53efbe388396 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:18:59Z |
| publishDate | 2018-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-37e699a318984ab4be1c53efbe3883962023-09-15T14:08:31ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532018-05-0129435336310.1080/09546634.2017.13957981395798Efficacy and safety of acitretin monotherapy in children with pustular psoriasis: results from 15 cases and a literature reviewPingjiao Chen0Changxing Li1Rujun Xue2Huiheng Chen3Xin Tian4Kang Zeng5Xibao Zhang6Jingyao Liang7Nanfang Hospital, Southern Medical UniversityDongguan Sixth People’s HospitalGuangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou Medical UniversityNanfang Hospital, Southern Medical UniversityGuangzhou Medical UniversityGuangzhou Medical UniversityBackground: There is a few evidence-based information regarding the efficacy and safety of acitretin treatment in children with pustular psoriasis (PP). Objective: This study aimed to provide an additional evidence for this field. Methods: A retrospective study was undertaken for 15 children with PP who received acitretin in doses of 0.6–1.0 mg/kg/day for 4–6 weeks, the transition dose of 0.2–0.4 mg/kg/day for 4–6 weeks and maintenance dose of 0.2–0.3 mg/kg/day. Additionally, a literature review on this topic is conducted. Results: Of 15 children with generalized PP (GPP, n = 10), palmoplantar psoriasis (PPP, n = 3), and acrodermatitis continua of Hallopeau (ACH, n = 2), 93.3% (14/15) showed good response, only one case with ACH exhibited moderate response. During the 10–32 months of follow-up, acitrerin monotherapy for children cases with PP overall showed good efficacy and safety. In the literature review, a total of 107 childhood PP cases treated with acitretin in 21 studies were included in the analysis. The clinical effectiveness was obtained in 88.8% (95/107) patients treated with acitretin as monotherapy or combination therapy, and most of cases (92.6%, 100/107) treated by acitretin did not report side effects during the treatment and follow-up of acitretin. Limitation: This study is just included a small sample sizes and no standardized studies were used in the literature. Conclusion: Acitretin therapy for children with PP (monotherapy or combination therapy), all showed a satisfactory therapeutic effect and safety, independent of the short or long-tern therapeutic procedures.http://dx.doi.org/10.1080/09546634.2017.1395798pustular psoriasisgeneralized pustular psoriasispalmoplantar psoriasisacitretinchildrentreatment |
| spellingShingle | Pingjiao Chen Changxing Li Rujun Xue Huiheng Chen Xin Tian Kang Zeng Xibao Zhang Jingyao Liang Efficacy and safety of acitretin monotherapy in children with pustular psoriasis: results from 15 cases and a literature review Journal of Dermatological Treatment pustular psoriasis generalized pustular psoriasis palmoplantar psoriasis acitretin children treatment |
| title | Efficacy and safety of acitretin monotherapy in children with pustular psoriasis: results from 15 cases and a literature review |
| title_full | Efficacy and safety of acitretin monotherapy in children with pustular psoriasis: results from 15 cases and a literature review |
| title_fullStr | Efficacy and safety of acitretin monotherapy in children with pustular psoriasis: results from 15 cases and a literature review |
| title_full_unstemmed | Efficacy and safety of acitretin monotherapy in children with pustular psoriasis: results from 15 cases and a literature review |
| title_short | Efficacy and safety of acitretin monotherapy in children with pustular psoriasis: results from 15 cases and a literature review |
| title_sort | efficacy and safety of acitretin monotherapy in children with pustular psoriasis results from 15 cases and a literature review |
| topic | pustular psoriasis generalized pustular psoriasis palmoplantar psoriasis acitretin children treatment |
| url | http://dx.doi.org/10.1080/09546634.2017.1395798 |
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