Up-regulation of Gr1 + CD11b + cell population in the spleen of NaClO-administered mice works to repair skin wounds
In wound healing, early infiltration of neutrophils followed by macrophage infiltration are important defense mechanisms for repair of tissue damage. Here we examined the effects of neutrophils on wound healing. Administration of sodium hypochlorite (NaClO) to mouse skin induces neutrophil recruitme...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2012-08-01
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| Series: | BioDiscovery |
| Subjects: | |
| Online Access: | https://biodiscovery.pensoft.net/article/8924/download/pdf/ |
| _version_ | 1828750740809580544 |
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| author | Mayu Hara Naomi Nishio Sachiko Ito Masashi Akiyama |
| author_facet | Mayu Hara Naomi Nishio Sachiko Ito Masashi Akiyama |
| author_sort | Mayu Hara |
| collection | DOAJ |
| description | In wound healing, early infiltration of neutrophils followed by macrophage infiltration are important defense mechanisms for repair of tissue damage. Here we examined the effects of neutrophils on wound healing. Administration of sodium hypochlorite (NaClO) to mouse skin induces neutrophil recruitment to the wound site and repeated administration of NaClO was shown to prolong wound healing. Examination of the spleens of mice whose wounds were repeatedly treated with NaClO, showed that GR-1<sup>+</sup>CD11b<sup>+</sup> cells were up regulated in the recovery phase of wounding. Many of the GR-1<sup>+</sup>CD11b <sup>+</sup> cells in the mouse bone marrow were neutrophils, as indicated by a ring-shaped nucleus, and some of the cells were immature myeloid-lineage cells. GR-1<sup>+</sup>CD11b<sup>+</sup> cells from bone marrow were sorted and injected intravenously to syngeneic Imprinting Control Region (ICR) mice. The mice that received GR-1<sup>+</sup>CD11b<sup>+</sup> cells recovered faster than the mice injected with the control, phosphate buffer saline (PBS). |
| first_indexed | 2024-12-10T20:42:48Z |
| format | Article |
| id | doaj.art-37e70a4a81c849cb99f64f8aa3c7fb60 |
| institution | Directory Open Access Journal |
| issn | 2050-2966 |
| language | English |
| last_indexed | 2024-12-10T20:42:48Z |
| publishDate | 2012-08-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | BioDiscovery |
| spelling | doaj.art-37e70a4a81c849cb99f64f8aa3c7fb602022-12-22T01:34:19ZengPensoft PublishersBioDiscovery2050-29662012-08-0121610.7750/BioDiscovery.2012.2.18924Up-regulation of Gr1 + CD11b + cell population in the spleen of NaClO-administered mice works to repair skin woundsMayu HaraNaomi NishioSachiko ItoMasashi AkiyamaIn wound healing, early infiltration of neutrophils followed by macrophage infiltration are important defense mechanisms for repair of tissue damage. Here we examined the effects of neutrophils on wound healing. Administration of sodium hypochlorite (NaClO) to mouse skin induces neutrophil recruitment to the wound site and repeated administration of NaClO was shown to prolong wound healing. Examination of the spleens of mice whose wounds were repeatedly treated with NaClO, showed that GR-1<sup>+</sup>CD11b<sup>+</sup> cells were up regulated in the recovery phase of wounding. Many of the GR-1<sup>+</sup>CD11b <sup>+</sup> cells in the mouse bone marrow were neutrophils, as indicated by a ring-shaped nucleus, and some of the cells were immature myeloid-lineage cells. GR-1<sup>+</sup>CD11b<sup>+</sup> cells from bone marrow were sorted and injected intravenously to syngeneic Imprinting Control Region (ICR) mice. The mice that received GR-1<sup>+</sup>CD11b<sup>+</sup> cells recovered faster than the mice injected with the control, phosphate buffer saline (PBS).https://biodiscovery.pensoft.net/article/8924/download/pdf/neutrophilswound healingGR-1+CD11b+ cells |
| spellingShingle | Mayu Hara Naomi Nishio Sachiko Ito Masashi Akiyama Up-regulation of Gr1 + CD11b + cell population in the spleen of NaClO-administered mice works to repair skin wounds BioDiscovery neutrophils wound healing GR-1+CD11b+ cells |
| title | Up-regulation of Gr1 + CD11b + cell population in the spleen of NaClO-administered mice works to repair skin wounds |
| title_full | Up-regulation of Gr1 + CD11b + cell population in the spleen of NaClO-administered mice works to repair skin wounds |
| title_fullStr | Up-regulation of Gr1 + CD11b + cell population in the spleen of NaClO-administered mice works to repair skin wounds |
| title_full_unstemmed | Up-regulation of Gr1 + CD11b + cell population in the spleen of NaClO-administered mice works to repair skin wounds |
| title_short | Up-regulation of Gr1 + CD11b + cell population in the spleen of NaClO-administered mice works to repair skin wounds |
| title_sort | up regulation of gr1 cd11b cell population in the spleen of naclo administered mice works to repair skin wounds |
| topic | neutrophils wound healing GR-1+CD11b+ cells |
| url | https://biodiscovery.pensoft.net/article/8924/download/pdf/ |
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