Large B-Cell Lymphomas in the 5th Edition of the WHO-Classification of Haematolymphoid Neoplasms—Updated Classification and New Concepts
The family/class of the large B-cell lymphomas (LBCL) in the 5th edition of the World Health Organization (WHO) classification of haematolymphoid tumors (WHO-HAEM5) features only a few major changes as compared to the 4th edition. In most entities, there are only subtle changes, many of them only re...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/8/2285 |
| _version_ | 1797606050300428288 |
|---|---|
| author | Katrin S. Kurz Michaela Ott Sabrina Kalmbach Sophia Steinlein Claudia Kalla Heike Horn German Ott Annette M. Staiger |
| author_facet | Katrin S. Kurz Michaela Ott Sabrina Kalmbach Sophia Steinlein Claudia Kalla Heike Horn German Ott Annette M. Staiger |
| author_sort | Katrin S. Kurz |
| collection | DOAJ |
| description | The family/class of the large B-cell lymphomas (LBCL) in the 5th edition of the World Health Organization (WHO) classification of haematolymphoid tumors (WHO-HAEM5) features only a few major changes as compared to the 4th edition. In most entities, there are only subtle changes, many of them only representing some minor modifications in diagnostic terms. Major changes have been made in the diffuse large B-cell lymphomas (DLBCL)/high-grade B-cell lymphomas (HGBL) associated with <i>MYC</i> and <i>BCL2</i> and/or <i>BCL6</i> rearrangements. This category now consists of <i>MYC</i> and <i>BCL2</i> rearranged cases exclusively, while the <i>MYC/BCL6</i> double hit lymphomas now constitute genetic subtypes of DLBCL, not otherwise specified (NOS) or of HGBL, NOS. Other major changes are the conceptual merger of lymphomas arising in immune-privileged sites and the description of LBCL arising in the setting of immune dysregulation/deficiency. In addition, novel findings concerning underlying biological mechanisms in the pathogenesis of the different entities are provided. |
| first_indexed | 2024-03-11T05:09:52Z |
| format | Article |
| id | doaj.art-37e8cf8e091e479bbfc40ff8e424bc23 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T05:09:52Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-37e8cf8e091e479bbfc40ff8e424bc232023-11-17T18:38:52ZengMDPI AGCancers2072-66942023-04-01158228510.3390/cancers15082285Large B-Cell Lymphomas in the 5th Edition of the WHO-Classification of Haematolymphoid Neoplasms—Updated Classification and New ConceptsKatrin S. Kurz0Michaela Ott1Sabrina Kalmbach2Sophia Steinlein3Claudia Kalla4Heike Horn5German Ott6Annette M. Staiger7Department of Clinical Pathology, Robert-Bosch-Krankenhaus, 70376 Stuttgart, GermanyDepartment of Pathology, Marienhospital, 70199 Stuttgart, GermanyDepartment of Clinical Pathology, Robert-Bosch-Krankenhaus, 70376 Stuttgart, GermanyDepartment of Clinical Pathology, Robert-Bosch-Krankenhaus, 70376 Stuttgart, GermanyDepartment of Clinical Pathology, Robert-Bosch-Krankenhaus, 70376 Stuttgart, GermanyDepartment of Clinical Pathology, Robert-Bosch-Krankenhaus, 70376 Stuttgart, GermanyDepartment of Clinical Pathology, Robert-Bosch-Krankenhaus, 70376 Stuttgart, GermanyDepartment of Clinical Pathology, Robert-Bosch-Krankenhaus, 70376 Stuttgart, GermanyThe family/class of the large B-cell lymphomas (LBCL) in the 5th edition of the World Health Organization (WHO) classification of haematolymphoid tumors (WHO-HAEM5) features only a few major changes as compared to the 4th edition. In most entities, there are only subtle changes, many of them only representing some minor modifications in diagnostic terms. Major changes have been made in the diffuse large B-cell lymphomas (DLBCL)/high-grade B-cell lymphomas (HGBL) associated with <i>MYC</i> and <i>BCL2</i> and/or <i>BCL6</i> rearrangements. This category now consists of <i>MYC</i> and <i>BCL2</i> rearranged cases exclusively, while the <i>MYC/BCL6</i> double hit lymphomas now constitute genetic subtypes of DLBCL, not otherwise specified (NOS) or of HGBL, NOS. Other major changes are the conceptual merger of lymphomas arising in immune-privileged sites and the description of LBCL arising in the setting of immune dysregulation/deficiency. In addition, novel findings concerning underlying biological mechanisms in the pathogenesis of the different entities are provided.https://www.mdpi.com/2072-6694/15/8/2285large B-cell lymphomadiffuse large B-cell lymphomaclassificationgeneticsWHO-HAEM5 |
| spellingShingle | Katrin S. Kurz Michaela Ott Sabrina Kalmbach Sophia Steinlein Claudia Kalla Heike Horn German Ott Annette M. Staiger Large B-Cell Lymphomas in the 5th Edition of the WHO-Classification of Haematolymphoid Neoplasms—Updated Classification and New Concepts Cancers large B-cell lymphoma diffuse large B-cell lymphoma classification genetics WHO-HAEM5 |
| title | Large B-Cell Lymphomas in the 5th Edition of the WHO-Classification of Haematolymphoid Neoplasms—Updated Classification and New Concepts |
| title_full | Large B-Cell Lymphomas in the 5th Edition of the WHO-Classification of Haematolymphoid Neoplasms—Updated Classification and New Concepts |
| title_fullStr | Large B-Cell Lymphomas in the 5th Edition of the WHO-Classification of Haematolymphoid Neoplasms—Updated Classification and New Concepts |
| title_full_unstemmed | Large B-Cell Lymphomas in the 5th Edition of the WHO-Classification of Haematolymphoid Neoplasms—Updated Classification and New Concepts |
| title_short | Large B-Cell Lymphomas in the 5th Edition of the WHO-Classification of Haematolymphoid Neoplasms—Updated Classification and New Concepts |
| title_sort | large b cell lymphomas in the 5th edition of the who classification of haematolymphoid neoplasms updated classification and new concepts |
| topic | large B-cell lymphoma diffuse large B-cell lymphoma classification genetics WHO-HAEM5 |
| url | https://www.mdpi.com/2072-6694/15/8/2285 |
| work_keys_str_mv | AT katrinskurz largebcelllymphomasinthe5theditionofthewhoclassificationofhaematolymphoidneoplasmsupdatedclassificationandnewconcepts AT michaelaott largebcelllymphomasinthe5theditionofthewhoclassificationofhaematolymphoidneoplasmsupdatedclassificationandnewconcepts AT sabrinakalmbach largebcelllymphomasinthe5theditionofthewhoclassificationofhaematolymphoidneoplasmsupdatedclassificationandnewconcepts AT sophiasteinlein largebcelllymphomasinthe5theditionofthewhoclassificationofhaematolymphoidneoplasmsupdatedclassificationandnewconcepts AT claudiakalla largebcelllymphomasinthe5theditionofthewhoclassificationofhaematolymphoidneoplasmsupdatedclassificationandnewconcepts AT heikehorn largebcelllymphomasinthe5theditionofthewhoclassificationofhaematolymphoidneoplasmsupdatedclassificationandnewconcepts AT germanott largebcelllymphomasinthe5theditionofthewhoclassificationofhaematolymphoidneoplasmsupdatedclassificationandnewconcepts AT annettemstaiger largebcelllymphomasinthe5theditionofthewhoclassificationofhaematolymphoidneoplasmsupdatedclassificationandnewconcepts |