The emerging roles and mechanism of m6a in breast cancer progression
Breast cancer (BC) has continued to be the leading cause of cancer deaths in women, accompanied by highly molecular heterogeneity. N6-methyladenosine (m6A), a methylation that happens on adenosine N6, is the most abundant internal mRNA modification type in eukaryotic cells. Functionally, m6A methyla...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.983564/full |
| _version_ | 1811309239819304960 |
|---|---|
| author | Mengying Zhou Menglu Dong Xue Yang Jun Gong Xinghua Liao Qi Zhang Zeming Liu |
| author_facet | Mengying Zhou Menglu Dong Xue Yang Jun Gong Xinghua Liao Qi Zhang Zeming Liu |
| author_sort | Mengying Zhou |
| collection | DOAJ |
| description | Breast cancer (BC) has continued to be the leading cause of cancer deaths in women, accompanied by highly molecular heterogeneity. N6-methyladenosine (m6A), a methylation that happens on adenosine N6, is the most abundant internal mRNA modification type in eukaryotic cells. Functionally, m6A methylation is a reversible modification process and is regulated by 3 enzymes with different functions, namely “writer”, “reader”, and “eraser”. Abnormal m6A modifications trigger the expression, activation, or inhibition of key signaling molecules in critical signaling pathways and the regulatory factors acting on them in BC. These m6A-related enzymes can not only be used as markers for accurate diagnosis, prediction of prognosis, and risk model construction, but also as effective targets for BC treatment. Here, we have emphasized the roles of different types of m6A-related enzymes reported in BC proliferation, invasion, and metastasis, as well as immune regulation. The comprehensive and in-depth exploration of the molecular mechanisms related to m6A will benefit in finding effective potential targets and effective stratified management of BC. |
| first_indexed | 2024-04-13T09:38:42Z |
| format | Article |
| id | doaj.art-37ea9c69b8e34fd593ad5cee5d208d65 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-13T09:38:42Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-37ea9c69b8e34fd593ad5cee5d208d652022-12-22T02:52:01ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-08-011310.3389/fgene.2022.983564983564The emerging roles and mechanism of m6a in breast cancer progressionMengying Zhou0Menglu Dong1Xue Yang2Jun Gong3Xinghua Liao4Qi Zhang5Zeming Liu6Institute of Biology and Medicine, College of Life and Health Sciences, Wuhan University of Science and Technology, Wuhan, ChinaDepartment of Thyroid and Breast Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Thyroid and Breast Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Biliary-Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Biology and Medicine, College of Life and Health Sciences, Wuhan University of Science and Technology, Wuhan, ChinaDepartment of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBreast cancer (BC) has continued to be the leading cause of cancer deaths in women, accompanied by highly molecular heterogeneity. N6-methyladenosine (m6A), a methylation that happens on adenosine N6, is the most abundant internal mRNA modification type in eukaryotic cells. Functionally, m6A methylation is a reversible modification process and is regulated by 3 enzymes with different functions, namely “writer”, “reader”, and “eraser”. Abnormal m6A modifications trigger the expression, activation, or inhibition of key signaling molecules in critical signaling pathways and the regulatory factors acting on them in BC. These m6A-related enzymes can not only be used as markers for accurate diagnosis, prediction of prognosis, and risk model construction, but also as effective targets for BC treatment. Here, we have emphasized the roles of different types of m6A-related enzymes reported in BC proliferation, invasion, and metastasis, as well as immune regulation. The comprehensive and in-depth exploration of the molecular mechanisms related to m6A will benefit in finding effective potential targets and effective stratified management of BC.https://www.frontiersin.org/articles/10.3389/fgene.2022.983564/fullbreast cancerM6Amethylationgene expressionmiRNAmetastasis |
| spellingShingle | Mengying Zhou Menglu Dong Xue Yang Jun Gong Xinghua Liao Qi Zhang Zeming Liu The emerging roles and mechanism of m6a in breast cancer progression Frontiers in Genetics breast cancer M6A methylation gene expression miRNA metastasis |
| title | The emerging roles and mechanism of m6a in breast cancer progression |
| title_full | The emerging roles and mechanism of m6a in breast cancer progression |
| title_fullStr | The emerging roles and mechanism of m6a in breast cancer progression |
| title_full_unstemmed | The emerging roles and mechanism of m6a in breast cancer progression |
| title_short | The emerging roles and mechanism of m6a in breast cancer progression |
| title_sort | emerging roles and mechanism of m6a in breast cancer progression |
| topic | breast cancer M6A methylation gene expression miRNA metastasis |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.983564/full |
| work_keys_str_mv | AT mengyingzhou theemergingrolesandmechanismofm6ainbreastcancerprogression AT mengludong theemergingrolesandmechanismofm6ainbreastcancerprogression AT xueyang theemergingrolesandmechanismofm6ainbreastcancerprogression AT jungong theemergingrolesandmechanismofm6ainbreastcancerprogression AT xinghualiao theemergingrolesandmechanismofm6ainbreastcancerprogression AT qizhang theemergingrolesandmechanismofm6ainbreastcancerprogression AT zemingliu theemergingrolesandmechanismofm6ainbreastcancerprogression AT mengyingzhou emergingrolesandmechanismofm6ainbreastcancerprogression AT mengludong emergingrolesandmechanismofm6ainbreastcancerprogression AT xueyang emergingrolesandmechanismofm6ainbreastcancerprogression AT jungong emergingrolesandmechanismofm6ainbreastcancerprogression AT xinghualiao emergingrolesandmechanismofm6ainbreastcancerprogression AT qizhang emergingrolesandmechanismofm6ainbreastcancerprogression AT zemingliu emergingrolesandmechanismofm6ainbreastcancerprogression |