Estrogen Regulates the Satellite Cell Compartment in Females
Summary: Skeletal muscle mass, strength, and regenerative capacity decline with age, with many measures showing a greater deterioration in females around the time estrogen levels decrease at menopause. Here, we show that estrogen deficiency severely compromises the maintenance of muscle stem cells (...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-07-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124719307910 |
| _version_ | 1818946825756868608 |
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| author | Brittany C. Collins Robert W. Arpke Alexie A. Larson Cory W. Baumann Ning Xie Christine A. Cabelka Nardina L. Nash Hanna-Kaarina Juppi Eija K. Laakkonen Sarianna Sipilä Vuokko Kovanen Espen E. Spangenburg Michael Kyba Dawn A. Lowe |
| author_facet | Brittany C. Collins Robert W. Arpke Alexie A. Larson Cory W. Baumann Ning Xie Christine A. Cabelka Nardina L. Nash Hanna-Kaarina Juppi Eija K. Laakkonen Sarianna Sipilä Vuokko Kovanen Espen E. Spangenburg Michael Kyba Dawn A. Lowe |
| author_sort | Brittany C. Collins |
| collection | DOAJ |
| description | Summary: Skeletal muscle mass, strength, and regenerative capacity decline with age, with many measures showing a greater deterioration in females around the time estrogen levels decrease at menopause. Here, we show that estrogen deficiency severely compromises the maintenance of muscle stem cells (i.e., satellite cells) as well as impairs self-renewal and differentiation into muscle fibers. Mechanistically, by hormone replacement, use of a selective estrogen-receptor modulator (bazedoxifene), and conditional estrogen receptor knockout, we implicate 17β-estradiol and satellite cell expression of estrogen receptor α and show that estrogen signaling through this receptor is necessary to prevent apoptosis of satellite cells. Early data from a biopsy study of women who transitioned from peri- to post-menopause are consistent with the loss of satellite cells coincident with the decline in estradiol in humans. Together, these results demonstrate an important role for estrogen in satellite cell maintenance and muscle regeneration in females. : Collins et al. show the loss of estrogen in female mice and post-menopausal women leads to a decrease in skeletal muscle stem cells. Using muscle stem cell-specific mutants, it was demonstrated that ERα is necessary for satellite cell maintenance, self-renewal, and protection from apoptosis, thereby promoting optimal muscle regeneration. Keywords: estradiol, muscle stem cells, ovarian hormones, quiescence, skeletal muscle |
| first_indexed | 2024-12-20T08:21:10Z |
| format | Article |
| id | doaj.art-37ec4ce13b9944809954e964e9bbeabf |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-20T08:21:10Z |
| publishDate | 2019-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-37ec4ce13b9944809954e964e9bbeabf2022-12-21T19:47:00ZengElsevierCell Reports2211-12472019-07-01282368381.e6Estrogen Regulates the Satellite Cell Compartment in FemalesBrittany C. Collins0Robert W. Arpke1Alexie A. Larson2Cory W. Baumann3Ning Xie4Christine A. Cabelka5Nardina L. Nash6Hanna-Kaarina Juppi7Eija K. Laakkonen8Sarianna Sipilä9Vuokko Kovanen10Espen E. Spangenburg11Michael Kyba12Dawn A. Lowe13Divisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, MN, USALillehei Heart Institute and Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN, USADepartment of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN, USADivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, MN, USALillehei Heart Institute and Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN, USADivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, MN, USADivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, MN, USAGerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, FinlandGerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, FinlandGerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, FinlandGerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, FinlandEast Carolina Diabetes and Obesity Institute, Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USALillehei Heart Institute and Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN, USADivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, MN, USA; Corresponding authorSummary: Skeletal muscle mass, strength, and regenerative capacity decline with age, with many measures showing a greater deterioration in females around the time estrogen levels decrease at menopause. Here, we show that estrogen deficiency severely compromises the maintenance of muscle stem cells (i.e., satellite cells) as well as impairs self-renewal and differentiation into muscle fibers. Mechanistically, by hormone replacement, use of a selective estrogen-receptor modulator (bazedoxifene), and conditional estrogen receptor knockout, we implicate 17β-estradiol and satellite cell expression of estrogen receptor α and show that estrogen signaling through this receptor is necessary to prevent apoptosis of satellite cells. Early data from a biopsy study of women who transitioned from peri- to post-menopause are consistent with the loss of satellite cells coincident with the decline in estradiol in humans. Together, these results demonstrate an important role for estrogen in satellite cell maintenance and muscle regeneration in females. : Collins et al. show the loss of estrogen in female mice and post-menopausal women leads to a decrease in skeletal muscle stem cells. Using muscle stem cell-specific mutants, it was demonstrated that ERα is necessary for satellite cell maintenance, self-renewal, and protection from apoptosis, thereby promoting optimal muscle regeneration. Keywords: estradiol, muscle stem cells, ovarian hormones, quiescence, skeletal musclehttp://www.sciencedirect.com/science/article/pii/S2211124719307910 |
| spellingShingle | Brittany C. Collins Robert W. Arpke Alexie A. Larson Cory W. Baumann Ning Xie Christine A. Cabelka Nardina L. Nash Hanna-Kaarina Juppi Eija K. Laakkonen Sarianna Sipilä Vuokko Kovanen Espen E. Spangenburg Michael Kyba Dawn A. Lowe Estrogen Regulates the Satellite Cell Compartment in Females Cell Reports |
| title | Estrogen Regulates the Satellite Cell Compartment in Females |
| title_full | Estrogen Regulates the Satellite Cell Compartment in Females |
| title_fullStr | Estrogen Regulates the Satellite Cell Compartment in Females |
| title_full_unstemmed | Estrogen Regulates the Satellite Cell Compartment in Females |
| title_short | Estrogen Regulates the Satellite Cell Compartment in Females |
| title_sort | estrogen regulates the satellite cell compartment in females |
| url | http://www.sciencedirect.com/science/article/pii/S2211124719307910 |
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