Mitochondrial DNA abnormalities provide mechanistic insight and predict reactive oxygen species-stimulating drug efficacy

Mitochondrial DNA abnormalities provide mechanistic insight and predict reactive oxygen species-stimulating drug efficacy

Abstract Background Associations between mitochondrial genetic abnormalities (variations and copy number, i.e. mtDNAcn, change) and elevated ROS have been reported in cancer compared to normal cells. Since excessive levels of ROS can trigger apoptosis, treating cancer cells with ROS-stimulating agen...

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Bibliographic Details
Main Authors: Tarek Zaidieh, James R. Smith, Karen E. Ball, Qian An
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Cancer
Subjects:
Mitochondrial DNA
MtDNA variations
MtDNA copy number
Reactive oxygen species
Cisplatin
Dequalinium chloride hydrate
Online Access:https://doi.org/10.1186/s12885-021-08155-2

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