The potential of Kebar grass extract on histopathological changes in kidneys of mice offspring from the parent exposed to carbofuran during the lactation period
This research aims to know the potential of kebar grass extract <em>(</em><em>Biophytum petersianum</em><em>)</em> in reducing the impact of kidney damage in mice offspring during the lactation period from parents exposed to carbofuran. Carbofuran, kebar grass ext...
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| Format: | Article |
| Language: | Arabic |
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University of Mosul, College of Veterinary Medicine
2022-10-01
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| Series: | Iraqi Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | https://www.vetmedmosul.com/article_174352_5cc5f22ea1d1d98ea5699cf13929580b.pdf |
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| author | Epy Luqman Ernestine Priyatna Maslichah Mafruchati Hani Plumeriastuti Widjiati Widjiati Viski Hendrawan |
| author_facet | Epy Luqman Ernestine Priyatna Maslichah Mafruchati Hani Plumeriastuti Widjiati Widjiati Viski Hendrawan |
| author_sort | Epy Luqman |
| collection | DOAJ |
| description | This research aims to know the potential of kebar grass extract <em>(</em><em>Biophytum petersianum</em><em>)</em> in reducing the impact of kidney damage in mice offspring during the lactation period from parents exposed to carbofuran. Carbofuran, kebar grass extract, and vitamin C are exposed orally postnatal day 1<sup>st</sup> until the 14<sup>th</sup> postnatal day after delivery. Forty-two mice adults in the lactation period were randomly into seven groups. This group consisted of K (aquadest control), P1 (carbofuran ¼ LD<sub>50</sub> 0.0125 mg/day), P2 (carbofuran 1/8 LD<sub>50</sub> 0.00625 mg/day), P3 (kebar grass extract 3.375 mg + carbofuran ¼ LD<sub>50</sub>), P4 (kebar grass extract 3.375 mg + carbofuran 1/8LD<sub>50</sub>), P5 (vitamin C 0.2 cc + carbofuran ¼ LD<sub>50</sub>), and P6 (vitamin C 0.2 cc + carbofuran 1/8 LD<sub>50</sub>). On the 15<sup>th</sup> day of experimental, offspring were randomly selected and dissected, and the kidney was taken to make a histopathology sample. This study shows that carbofuran caused increased tubular degeneration, necrosis, and inflammation (p<0.05). Kebar grass extract could decrease tubular degeneration, necrosis, and inflammation (p<0.05). Kebar grass extract was more effective than vitamin C in reducing kidney damage in mice offspring during the lactation period from parents exposed to carbofuran(p<0.05). |
| first_indexed | 2024-04-13T19:52:34Z |
| format | Article |
| id | doaj.art-37eea507f0ac465fb24f806657a3f22e |
| institution | Directory Open Access Journal |
| issn | 1607-3894 2071-1255 |
| language | Arabic |
| last_indexed | 2024-04-13T19:52:34Z |
| publishDate | 2022-10-01 |
| publisher | University of Mosul, College of Veterinary Medicine |
| record_format | Article |
| series | Iraqi Journal of Veterinary Sciences |
| spelling | doaj.art-37eea507f0ac465fb24f806657a3f22e2022-12-22T02:32:27ZaraUniversity of Mosul, College of Veterinary MedicineIraqi Journal of Veterinary Sciences1607-38942071-12552022-10-013641075108210.33899/ijvs.2022.133065.2170174352The potential of Kebar grass extract on histopathological changes in kidneys of mice offspring from the parent exposed to carbofuran during the lactation periodEpy Luqman0Ernestine Priyatna1Maslichah Mafruchati2Hani Plumeriastuti3Widjiati Widjiati4Viski Hendrawan5Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga Jl Muyorejo Surabaya, 60115 IndonesiaDepartment of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga Jl Muyorejo Surabaya, 60115 IndonesiaDepartment of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga Jl Muyorejo Surabaya, 60115 IndonesiaDepartment of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga Jl Muyorejo Surabaya, 60115 IndonesiaDepartment of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga Jl Muyorejo Surabaya, 60115 IndonesiaDepartment of Animal Reproduction Faculty of Veterinary Medicine, Universitas Brawijaya, Jl. MT. Haryono No.169, Ketawanggede, Lowokwaru, Kota Malang, 65144 IndonesiaThis research aims to know the potential of kebar grass extract <em>(</em><em>Biophytum petersianum</em><em>)</em> in reducing the impact of kidney damage in mice offspring during the lactation period from parents exposed to carbofuran. Carbofuran, kebar grass extract, and vitamin C are exposed orally postnatal day 1<sup>st</sup> until the 14<sup>th</sup> postnatal day after delivery. Forty-two mice adults in the lactation period were randomly into seven groups. This group consisted of K (aquadest control), P1 (carbofuran ¼ LD<sub>50</sub> 0.0125 mg/day), P2 (carbofuran 1/8 LD<sub>50</sub> 0.00625 mg/day), P3 (kebar grass extract 3.375 mg + carbofuran ¼ LD<sub>50</sub>), P4 (kebar grass extract 3.375 mg + carbofuran 1/8LD<sub>50</sub>), P5 (vitamin C 0.2 cc + carbofuran ¼ LD<sub>50</sub>), and P6 (vitamin C 0.2 cc + carbofuran 1/8 LD<sub>50</sub>). On the 15<sup>th</sup> day of experimental, offspring were randomly selected and dissected, and the kidney was taken to make a histopathology sample. This study shows that carbofuran caused increased tubular degeneration, necrosis, and inflammation (p<0.05). Kebar grass extract could decrease tubular degeneration, necrosis, and inflammation (p<0.05). Kebar grass extract was more effective than vitamin C in reducing kidney damage in mice offspring during the lactation period from parents exposed to carbofuran(p<0.05).https://www.vetmedmosul.com/article_174352_5cc5f22ea1d1d98ea5699cf13929580b.pdfcarbofuranlactationkidneykebar grass extractpesticide stress |
| spellingShingle | Epy Luqman Ernestine Priyatna Maslichah Mafruchati Hani Plumeriastuti Widjiati Widjiati Viski Hendrawan The potential of Kebar grass extract on histopathological changes in kidneys of mice offspring from the parent exposed to carbofuran during the lactation period Iraqi Journal of Veterinary Sciences carbofuran lactation kidney kebar grass extract pesticide stress |
| title | The potential of Kebar grass extract on histopathological changes in kidneys of mice offspring from the parent exposed to carbofuran during the lactation period |
| title_full | The potential of Kebar grass extract on histopathological changes in kidneys of mice offspring from the parent exposed to carbofuran during the lactation period |
| title_fullStr | The potential of Kebar grass extract on histopathological changes in kidneys of mice offspring from the parent exposed to carbofuran during the lactation period |
| title_full_unstemmed | The potential of Kebar grass extract on histopathological changes in kidneys of mice offspring from the parent exposed to carbofuran during the lactation period |
| title_short | The potential of Kebar grass extract on histopathological changes in kidneys of mice offspring from the parent exposed to carbofuran during the lactation period |
| title_sort | potential of kebar grass extract on histopathological changes in kidneys of mice offspring from the parent exposed to carbofuran during the lactation period |
| topic | carbofuran lactation kidney kebar grass extract pesticide stress |
| url | https://www.vetmedmosul.com/article_174352_5cc5f22ea1d1d98ea5699cf13929580b.pdf |
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