| Summary: | Objective: To analyze the serum levels of miR-126, miR-146a and its relationship with
infarction area, severity of disease and inflammatory reaction degree in patients with
acute cerebral infarction (ACI).
Methods: A total of 75 cases with ACI treated in our hospital from April 2014 to
October 2015 and 80 healthy cases were respectively selected as ACI group and control
group for retrospective study. Patients' clinical data were collected, and the serum levels
of miR-126, miR-146a, tumor necrosis factor-a (TNF-a), interleukin-1b (IL-1b) and IL-6
were detected.
Results: Serum contents of miR-126 (0.286 ± 0.078 vs. 1.000 ± 0.169) and miR-146a
(0.337 ± 0.084 vs. 1.000 ± 0.158) in patients of ACI group were significantly lower
than those of control group. Contents of IL-1b [(68.4 ± 10.3) vs. (22.7 ± 5.8) ng/L], TNFa [(126.9 ± 22.4) vs. (49.6 ± 8.4) ng/L] and IL-6 [(89.3 ± 14.7) vs. (34.8 ± 5.9) ng/L]
were obviously higher than those of control group. The bigger the infarction area was, the
more severer the degree of nerve defect could be. The lower the serum levels of miR-126,
miR-146a were, the higher the levels of TNF-a, IL-1b, IL-6 could be. Levels of miR-126
and miR-146a were negative correlation with levels of TNF-a, IL-1b and IL-6.
Conclusions: An abnormal decrease in serum levels of miR-126 and miR-146a in patients with ACI was closely related to the severity of disease. Through regulating the
generation of inflammatory factors TNF-a, IL-1b and IL-6, miR-126 and miR-146a may
get involved in the changes of cerebral infarction condition.
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