Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation

Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation

Abstract Background PINK1 deficiency causes the autosomal recessive PARK6 variant of Parkinson’s disease. PINK1 activates ubiquitin by phosphorylation and cooperates with the downstream ubiquitin ligase PARKIN, to exert quality control and control autophagic degradation of mitochondria and of misfol...

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Main Authors: Sylvia Torres-Odio, Jana Key, Hans-Hermann Hoepken, Júlia Canet-Pons, Lucie Valek, Bastian Roller, Michael Walter, Blas Morales-Gordo, David Meierhofer, Patrick N. Harter, Michel Mittelbronn, Irmgard Tegeder, Suzana Gispert, Georg Auburger
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Journal of Neuroinflammation
Subjects:
Parkinson’s disease
Ubiquitin kinase PINK1
Mitochondrial dysfunction
Antiviral response
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-017-0928-0

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