Determination of ovarian reserve in different age groups of infertile women
Background: Infertility is a major global issue, and the childbearing potential can be estimated by determining the ovarian reserve. Ovarian reserve is described as a quantity of the ovarian follicles and quality of oocytes. Aims and Objectives: The objective of our study was to identify the correla...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Journal of the Scientific Society |
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| Online Access: | http://www.jscisociety.com/article.asp?issn=0974-5009;year=2020;volume=47;issue=3;spage=164;epage=167;aulast=Wani |
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| author | Saima Wani Shaheera Ajaz Lubna Rashid Javid Ahmed Rabiya Khurshid Aabida Ahmed |
| author_facet | Saima Wani Shaheera Ajaz Lubna Rashid Javid Ahmed Rabiya Khurshid Aabida Ahmed |
| author_sort | Saima Wani |
| collection | DOAJ |
| description | Background: Infertility is a major global issue, and the childbearing potential can be estimated by determining the ovarian reserve. Ovarian reserve is described as a quantity of the ovarian follicles and quality of oocytes. Aims and Objectives: The objective of our study was to identify the correlations between follicle-stimulating hormone (FSH), luteinizing hormone (LH), anti-Müllerian hormone (AMH), and antral follicle count (AFC) in different age groups of infertile women and to distinguish the most reliable marker for ovarian reserve with the objective of selecting a strategy for initial stages of infertility management. Materials and Methods: In this prospective study, 101 infertile women were assessed. The study participants were divided into three age groups: 20–29 years, 30–39 years, and >40 years. FSH, LH, AMH, and AFC were done on day 2–3 of menstrual cycle. Results: A total of 101 infertile women were assessed in our study. The mean age of the participants was 33.3 ± 4.37 years and the mean infertility period was 3.36 ± 2.26 years. The mean body mass index was 23.75 ± 2.97 kg/m2. The mean FSH level was 8.18 ± 5.54 and the mean AMH was 1.98 ± 1.0. The mean AFC was 9.29 ± 5.09. There was a statistically significantly elevated negative correlation between age and AMH level (rs = -0.667, P < 0.0001) and AFC (rs = -0.64, P < 0.0001). We observed a statistically significantly positive correlation between age and FSH (rs = 0.569, P < 0.0001). The correlation analysis performed in separate groups showed that AMH and AFC showed a statistically significant positive correlation for Group I (r = 0.953, P < 0.0001), Group II (r = 0.966, P < 0.0001), and Group III (r = 0.865, P < 0.001). A statistically significant negative correlation between FSH/LH and AMH was detected only in Group II (r = -0.661, P < 0.0001) and Group III (r = -0.735, P < 0.003). A statistically significant correlation existed between FSH and AFC in Group II (r = -0.657, P < 0.000), Group III (r = -0.664, P < 0.01), as well as between age and FSH only in Group III (r = 0.551, P < 0.04). Conclusion: AMH is more reliable marker of ovarian reserve compared to FSH/LH as the correlation between AMH and AFC is strongly positive. AMH can detect decrease in ovarian reserve much earlier than FSH/LH. The use of AMH combined with AFC definitely improves the evaluation of ovarian reserve in all age groups of infertile women. |
| first_indexed | 2024-12-20T10:26:00Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 0974-5009 |
| language | English |
| last_indexed | 2024-12-20T10:26:00Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | Journal of the Scientific Society |
| spelling | doaj.art-37f2d28c07d64024bbf724c41974c64f2022-12-21T19:43:49ZengWolters Kluwer Medknow PublicationsJournal of the Scientific Society0974-50092020-01-0147316416710.4103/jss.JSS_44_20Determination of ovarian reserve in different age groups of infertile womenSaima WaniShaheera AjazLubna RashidJavid AhmedRabiya KhurshidAabida AhmedBackground: Infertility is a major global issue, and the childbearing potential can be estimated by determining the ovarian reserve. Ovarian reserve is described as a quantity of the ovarian follicles and quality of oocytes. Aims and Objectives: The objective of our study was to identify the correlations between follicle-stimulating hormone (FSH), luteinizing hormone (LH), anti-Müllerian hormone (AMH), and antral follicle count (AFC) in different age groups of infertile women and to distinguish the most reliable marker for ovarian reserve with the objective of selecting a strategy for initial stages of infertility management. Materials and Methods: In this prospective study, 101 infertile women were assessed. The study participants were divided into three age groups: 20–29 years, 30–39 years, and >40 years. FSH, LH, AMH, and AFC were done on day 2–3 of menstrual cycle. Results: A total of 101 infertile women were assessed in our study. The mean age of the participants was 33.3 ± 4.37 years and the mean infertility period was 3.36 ± 2.26 years. The mean body mass index was 23.75 ± 2.97 kg/m2. The mean FSH level was 8.18 ± 5.54 and the mean AMH was 1.98 ± 1.0. The mean AFC was 9.29 ± 5.09. There was a statistically significantly elevated negative correlation between age and AMH level (rs = -0.667, P < 0.0001) and AFC (rs = -0.64, P < 0.0001). We observed a statistically significantly positive correlation between age and FSH (rs = 0.569, P < 0.0001). The correlation analysis performed in separate groups showed that AMH and AFC showed a statistically significant positive correlation for Group I (r = 0.953, P < 0.0001), Group II (r = 0.966, P < 0.0001), and Group III (r = 0.865, P < 0.001). A statistically significant negative correlation between FSH/LH and AMH was detected only in Group II (r = -0.661, P < 0.0001) and Group III (r = -0.735, P < 0.003). A statistically significant correlation existed between FSH and AFC in Group II (r = -0.657, P < 0.000), Group III (r = -0.664, P < 0.01), as well as between age and FSH only in Group III (r = 0.551, P < 0.04). Conclusion: AMH is more reliable marker of ovarian reserve compared to FSH/LH as the correlation between AMH and AFC is strongly positive. AMH can detect decrease in ovarian reserve much earlier than FSH/LH. The use of AMH combined with AFC definitely improves the evaluation of ovarian reserve in all age groups of infertile women.http://www.jscisociety.com/article.asp?issn=0974-5009;year=2020;volume=47;issue=3;spage=164;epage=167;aulast=Wanianti-müllerian hormoneantral follicle countfollicle-stimulating hormoneluteinizing hormoneovarian reserve |
| spellingShingle | Saima Wani Shaheera Ajaz Lubna Rashid Javid Ahmed Rabiya Khurshid Aabida Ahmed Determination of ovarian reserve in different age groups of infertile women Journal of the Scientific Society anti-müllerian hormone antral follicle count follicle-stimulating hormone luteinizing hormone ovarian reserve |
| title | Determination of ovarian reserve in different age groups of infertile women |
| title_full | Determination of ovarian reserve in different age groups of infertile women |
| title_fullStr | Determination of ovarian reserve in different age groups of infertile women |
| title_full_unstemmed | Determination of ovarian reserve in different age groups of infertile women |
| title_short | Determination of ovarian reserve in different age groups of infertile women |
| title_sort | determination of ovarian reserve in different age groups of infertile women |
| topic | anti-müllerian hormone antral follicle count follicle-stimulating hormone luteinizing hormone ovarian reserve |
| url | http://www.jscisociety.com/article.asp?issn=0974-5009;year=2020;volume=47;issue=3;spage=164;epage=167;aulast=Wani |
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