Pirfenidone induces translocation of sirt1 to nucleus and deacetylation of histone 3 slows down the development of fibrosis and tumorigenicity in a experimental model of hepatocarcinoma.

Pirfenidone induces translocation of sirt1 to nucleus and deacetylation of histone 3 slows down the development of fibrosis and tumorigenicity in a experimental model of hepatocarcinoma.

Introduction and objectives: Hepatocellular carcinoma (HCC) is the most common liver neoplasm worldwide. Pro-inflammatory and pro-fibrogenic processes are key in tumor development. On the other hand, Pirfenidone (PFD) has anti-inflammatory and antifibrogenic properties useful to counteract hepatocar...

Full description

Bibliographic Details
Main Authors:	Hugo C. Monroy-Ramírez, Scarlet Arceo-Orozco, Araceli G. Rivera-Cabral, Marina Galicia-Moreno, Juan Armendáriz-Borunda
Format:	Article
Language:	English
Published:	Elsevier 2024-02-01
Series:	Annals of Hepatology
Online Access:	http://www.sciencedirect.com/science/article/pii/S1665268124001959

Similar Items

Pirfenidone slows the development of fibrosis and malignant neoplasms by modulating inflammation in an experimental model of hepatocarcinoma.
by: Scarlet Arceo-Orozco, et al.
Published: (2024-02-01)

Pirfenidone Reverts Global DNA Hypomethylation, Promoting DNMT1/UHRF/PCNA Coupling Complex in Experimental Hepatocarcinoma
by: Hipolito Otoniel Miranda-Roblero, et al.
Published: (2024-06-01)

Binding to nucleosome poises human SIRT6 for histone H3 deacetylation
by: Ekaterina Smirnova, et al.
Published: (2024-02-01)

Pirfenidone Is an Agonistic Ligand for PPARα and Improves NASH by Activation of SIRT1/LKB1/pAMPK
by: Ana Sandoval‐Rodriguez, et al.
Published: (2020-03-01)

Hepatoprotective effects of N-acetylcysteine prevents hepatocellular carcinoma development induced experimentally.
by: Fernando Caloca-Camarena, et al.
Published: (2024-02-01)

Pirfenidone Protects from UVB-Induced Photodamage in Hairless Mice
by: Yocasta Martinez-Alvarado, et al.
Published: (2023-03-01)

P- 43 PIRFENIDONE PREVENTS NEOPLASTIC LESIONS DEVELOPMENT BY OXIDATIVE, FIBROGENIC, ANTIPROLIFERATIVE AND EPIGENETIC MECHANISMS REGULATION IN A MODEL OF CHEMICAL HEPATOCARCINOGENESIS
by: Hipólito Otoniel Miranda-Roblero, et al.
Published: (2023-03-01)

O-24 PIRFENIDONE PREVENTS NEOPLASTIC LESIONS DEVELOPMENT BY OXIDATIVE, FIBROGENIC, ANTIPROLIFERATIVE AND EPIGENETIC MECHANISMS REGULATION IN A MODEL OF CHEMICAL HEPATOCARCINOGENESIS
by: Hipólito Otoniel Miranda-Roblero, et al.
Published: (2023-03-01)

Roles of Histone Acetylation and Deacetylation in Root Development
by: Christos Tersenidis, et al.
Published: (2024-10-01)

Activation of SIRT6 Deacetylation by DNA Strand Breaks
by: Wenjia Kang, et al.
Published: (2023-10-01)

Histone deacetylase 3 regulates microglial function through histone deacetylation
by: Laura Meleady, et al.
Published: (2023-12-01)

Histone deacetylation promotes transcriptional silencing at facultative heterochromatin
by: Watts, B, et al.
Published: (2018)

More than just a histone deacetylase: cytoplasmic SIRT6 facilitates fatty acid oxidation through ACSL5 deacetylation
by: Li Shuoshuo, et al.
Published: (2023-03-01)

Acetylation and deacetylation of histone in adipocyte differentiation and the potential significance in cancer
by: Xiaorui Wang, et al.
Published: (2024-01-01)

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin
by: Simic, Petra, et al.
Published: (2014)

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle
by: Nakagawa, Takashi, et al.
Published: (2014)

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin
by: Petra Simic, et al.
Published: (2013-01-01)

Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to modulate renal fibrosis through alternative splicing-mediated upregulation of CCN2
by: Guangyan Yang, et al.
Published: (2024-11-01)

Characterization of the histone deacetylation activity of the yeast silencing gene SIR2
by: Armstrong, Christopher Mark, 1972-
Published: (2005)

Modulation of biological activities in adipose derived stem cells by histone deacetylation
by: Sallam Abdallah, et al.
Published: (2025-01-01)

Erratum To: SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin
by: Petra Simic, et al.
Published: (2013-03-01)

CSE triggers ferroptosis via SIRT4-mediated GNPAT deacetylation in the pathogenesis of COPD
by: Congping Li, et al.
Published: (2023-12-01)

Deacetylation via SIRT2 prevents keratin-mutation-associated injury and keratin aggregation
by: Jingyuan Sun, et al.
Published: (2023-07-01)

Topical Pirfenidone-Loaded Liposomes Ophthalmic Formulation Reduces Haze Development after Corneal Alkali Burn in Mice
by: Carlos Daniel Diaz-Palomera, et al.
Published: (2022-01-01)

Pirfenidone decreases insulin, glucagon, leptin, plasminogen activator inhibitor 1, preventing nonalcoholic steatohepatitis and myocarditis in an obesity moldel
by: Daniel López-Cifuentes, et al.
Published: (2024-02-01)

Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice
by: Kimberly K. Richardson, et al.
Published: (2024-10-01)

Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer
by: José Manuel García-Martínez, et al.
Published: (2023-08-01)

PGAM5 deacetylation mediated by SIRT2 facilitates lipid metabolism and liver cancer proliferation
by: Fu Gongyu, et al.
Published: (2023-08-01)

Clinical trial landscape for histone deacetylation inhibitors in breast cancer: a dawn in the darkness?
by: Jiajun Li, et al.
Published: (2024-11-01)

Histone deacetylase 8 promotes innate antiviral immunity through deacetylation of RIG-I
by: Huijun Zhang, et al.
Published: (2024-07-01)

The epigenetic regulatory effect of histone acetylation and deacetylation on skeletal muscle metabolism-a review
by: Junjie Xu, et al.
Published: (2023-12-01)

Histone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1
by: Jie-lin Tang, et al.
Published: (2020-08-01)

H3K9me3 demethylation by JMJD2B is regulated by pirfenidone resulting in improved NASH
by: J. Samael Rodriguez-Sanabria, et al.
Published: (2024-10-01)

Hepatocarcinoma invadiendo estómago
by: A. Guzmán-Lepe, et al.
Published: (2021-01-01)

Sevoflurane Ameliorates Myocardial Cell Injury by Inducing Autophagy via the Deacetylation of LC3 by SIRT1
by: Lihua Fan, et al.
Published: (2017-01-01)

SIRT1-mediated deacetylation of FOXO3 enhances mitophagy and drives hormone resistance in endometrial cancer
by: Xuehua Wei, et al.
Published: (2024-09-01)

SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury
by: Yingting Zhang, et al.
Published: (2021-10-01)

SIRT-3 Modulation by Resveratrol Improves Mitochondrial Oxidative Phosphorylation in Diabetic Heart through Deacetylation of TFAM
by: Pankaj K. Bagul, et al.
Published: (2018-11-01)

Analysis of histone deacetylation activities in Ananas comosus var. MD2 after mutagenic treatment
by: Yaacob, J.S., et al.
Published: (2017)

Protein profiling and histone deacetylation activities in somaclonal variants of oil palm (Elaeis guineensis Jacq.)
by: Yaacob, J.S., et al.
Published: (2013)