Modern aspects of anticonvulsant pharmacotherapy in newborns
Proper treatment of neonatal seizures is crucial for reducing long-term neurological disorders. None of the currently used drugs to treat neonatal seizures has sufficient evidentiary base to make an unambiguous conclusion about its effectiveness. There are no results of large-scale studies that allo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Ltd. “The National Academy of Pediatric Science and Innovation”
2022-04-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/1573 |
| _version_ | 1797875089821138944 |
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| author | V. Yu. Perfil’ev A. G. Miroshnichenko V. A. Zhelev E. V. Devald |
| author_facet | V. Yu. Perfil’ev A. G. Miroshnichenko V. A. Zhelev E. V. Devald |
| author_sort | V. Yu. Perfil’ev |
| collection | DOAJ |
| description | Proper treatment of neonatal seizures is crucial for reducing long-term neurological disorders. None of the currently used drugs to treat neonatal seizures has sufficient evidentiary base to make an unambiguous conclusion about its effectiveness. There are no results of large-scale studies that allow choosing an anticonvulsant drug for starting therapy and an alternative to it, in case the drug of choice is ineffective. The review summarizes the data on the effectiveness of anticonvulsants of different pharmacologic classes and considers their benefits, drawbacks, and possible mechanisms of variability in effectiveness when used in newborns. The review also analyzes approaches to the duration of the anticonvulsant therapy and discusses the problems and prospects of clinical trials for increasing the effectiveness and safety of anticonvulsant therapy in newborns. |
| first_indexed | 2024-04-10T01:41:10Z |
| format | Article |
| id | doaj.art-37f5941028ec401183a5b81bfec9fd63 |
| institution | Directory Open Access Journal |
| issn | 1027-4065 2500-2228 |
| language | Russian |
| last_indexed | 2024-04-10T01:41:10Z |
| publishDate | 2022-04-01 |
| publisher | Ltd. “The National Academy of Pediatric Science and Innovation” |
| record_format | Article |
| series | Rossijskij Vestnik Perinatologii i Pediatrii |
| spelling | doaj.art-37f5941028ec401183a5b81bfec9fd632023-03-13T09:12:52ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282022-04-01671142010.21508/1027-4065-2022-67-1-14-201150Modern aspects of anticonvulsant pharmacotherapy in newbornsV. Yu. Perfil’ev0A. G. Miroshnichenko1V. A. Zhelev2E. V. Devald3ФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава РоссииProper treatment of neonatal seizures is crucial for reducing long-term neurological disorders. None of the currently used drugs to treat neonatal seizures has sufficient evidentiary base to make an unambiguous conclusion about its effectiveness. There are no results of large-scale studies that allow choosing an anticonvulsant drug for starting therapy and an alternative to it, in case the drug of choice is ineffective. The review summarizes the data on the effectiveness of anticonvulsants of different pharmacologic classes and considers their benefits, drawbacks, and possible mechanisms of variability in effectiveness when used in newborns. The review also analyzes approaches to the duration of the anticonvulsant therapy and discusses the problems and prospects of clinical trials for increasing the effectiveness and safety of anticonvulsant therapy in newborns.https://www.ped-perinatology.ru/jour/article/view/1573новорожденныесудорогилечениепротивосудорожная терапия |
| spellingShingle | V. Yu. Perfil’ev A. G. Miroshnichenko V. A. Zhelev E. V. Devald Modern aspects of anticonvulsant pharmacotherapy in newborns Rossijskij Vestnik Perinatologii i Pediatrii новорожденные судороги лечение противосудорожная терапия |
| title | Modern aspects of anticonvulsant pharmacotherapy in newborns |
| title_full | Modern aspects of anticonvulsant pharmacotherapy in newborns |
| title_fullStr | Modern aspects of anticonvulsant pharmacotherapy in newborns |
| title_full_unstemmed | Modern aspects of anticonvulsant pharmacotherapy in newborns |
| title_short | Modern aspects of anticonvulsant pharmacotherapy in newborns |
| title_sort | modern aspects of anticonvulsant pharmacotherapy in newborns |
| topic | новорожденные судороги лечение противосудорожная терапия |
| url | https://www.ped-perinatology.ru/jour/article/view/1573 |
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