Stearoyl-CoA Desaturase (SCD) Induces Cardiac Dysfunction with Cardiac Lipid Overload and Angiotensin II AT1 Receptor Protein Up-Regulation

Stearoyl-CoA Desaturase (SCD) Induces Cardiac Dysfunction with Cardiac Lipid Overload and Angiotensin II AT1 Receptor Protein Up-Regulation

Heart failure is a major cause of death worldwide with insufficient treatment options. In the search for pathomechanisms, we found up-regulation of an enzyme, stearoyl-CoA desaturase 1 (<i>Scd1</i>), in different experimental models of heart failure induced by advanced atherosclerosis, c...

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Bibliographic Details
Main Authors: Joshua Abd Alla, Yahya F. Jamous, Ursula Quitterer
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
SCD
Scd1
transgenic mice
heart failure
lipid overload
angiotensin II
Online Access:https://www.mdpi.com/1422-0067/22/18/9883

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