Metformin does not slow cyst growth in the PCK rat model of polycystic kidney disease

Metformin does not slow cyst growth in the PCK rat model of polycystic kidney disease

Abstract Metformin (MET) has the potential to activate p‐AMPK and block mTORC1‐induced proliferation of tubular cells in PKD kidneys. The aim of this study was to determine the effects of MET on cyst growth, kidney function, AMPK and mTOR signaling, and lactate levels in male PCK rats, a Pkhd1 gene...

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Bibliographic Details
Main Authors:	Ozgur A. Oto, Daniel J. Atwood, Anjana Chaudhary, Zhibin He, Amy S. Li, Michael F. Wempe, Charles L. Edelstein
Format:	Article
Language:	English
Published:	Wiley 2023-09-01
Series:	Physiological Reports
Subjects:	metformin polycystic kidney
Online Access:	https://doi.org/10.14814/phy2.15776

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