Changes in Body Weight in Severely Obese Patients Treated with the Anorexiant Mazindol
(1) <b>Background</b>: The number of severely obese patients worldwide is rapidly increasing. Recently, novel therapeutic approaches, such as bariatric surgery or GLP-1 receptor agonists, have emerged, bringing about a paradigm shift in this field. However, these therapies sometimes face...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/7/1860 |
| _version_ | 1797212419823501312 |
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| author | Yoshimitsu Tanaka Norikazu Maeda Masahiro Koseki Kazuhisa Maeda |
| author_facet | Yoshimitsu Tanaka Norikazu Maeda Masahiro Koseki Kazuhisa Maeda |
| author_sort | Yoshimitsu Tanaka |
| collection | DOAJ |
| description | (1) <b>Background</b>: The number of severely obese patients worldwide is rapidly increasing. Recently, novel therapeutic approaches, such as bariatric surgery or GLP-1 receptor agonists, have emerged, bringing about a paradigm shift in this field. However, these therapies sometimes face challenges, such as peri-surgical complications or supply shortages. Mazindol, which is an appetite suppressant approved decades ago in Japan, remains a valuable option. In this study, we investigated the effectiveness of mazindol in reducing body weight in 147 patients, and we examined the factors influencing said effectiveness. (2) <b>Methods</b>: The patients were divided into four groups based on the treatment cycles they underwent: 1 cycle, 2 cycles, 3–5 cycles, and over 6 cycles. We compared the changes in body weight before and after the treatment among these four groups. Additionally, we sought to identify the factors correlated to the effectiveness of mazindol. (3) <b>Results</b>: The change in body weight was more pronounced in the group which underwent 3–5 cycles compared to the groups which underwent 1 cycle and 2 cycles; this change was also more pronounced in the group which underwent over 6 cycles compared to those which underwent 1 cycle. Furthermore, we observed a significant correlation between the initial body weight and the extent of body weight change. (4) <b>Conclusions</b>: Mazindol demonstrated effectiveness in reducing the body weight of patients in a cycle-dependent manner. |
| first_indexed | 2024-04-24T10:42:05Z |
| format | Article |
| id | doaj.art-37fa3924415647efb23a052ba508f201 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-24T10:42:05Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-37fa3924415647efb23a052ba508f2012024-04-12T13:20:52ZengMDPI AGJournal of Clinical Medicine2077-03832024-03-01137186010.3390/jcm13071860Changes in Body Weight in Severely Obese Patients Treated with the Anorexiant MazindolYoshimitsu Tanaka0Norikazu Maeda1Masahiro Koseki2Kazuhisa Maeda3Longwood Maeda Clinic, Suita 565-0874, JapanLongwood Maeda Clinic, Suita 565-0874, JapanLongwood Maeda Clinic, Suita 565-0874, JapanLongwood Maeda Clinic, Suita 565-0874, Japan(1) <b>Background</b>: The number of severely obese patients worldwide is rapidly increasing. Recently, novel therapeutic approaches, such as bariatric surgery or GLP-1 receptor agonists, have emerged, bringing about a paradigm shift in this field. However, these therapies sometimes face challenges, such as peri-surgical complications or supply shortages. Mazindol, which is an appetite suppressant approved decades ago in Japan, remains a valuable option. In this study, we investigated the effectiveness of mazindol in reducing body weight in 147 patients, and we examined the factors influencing said effectiveness. (2) <b>Methods</b>: The patients were divided into four groups based on the treatment cycles they underwent: 1 cycle, 2 cycles, 3–5 cycles, and over 6 cycles. We compared the changes in body weight before and after the treatment among these four groups. Additionally, we sought to identify the factors correlated to the effectiveness of mazindol. (3) <b>Results</b>: The change in body weight was more pronounced in the group which underwent 3–5 cycles compared to the groups which underwent 1 cycle and 2 cycles; this change was also more pronounced in the group which underwent over 6 cycles compared to those which underwent 1 cycle. Furthermore, we observed a significant correlation between the initial body weight and the extent of body weight change. (4) <b>Conclusions</b>: Mazindol demonstrated effectiveness in reducing the body weight of patients in a cycle-dependent manner.https://www.mdpi.com/2077-0383/13/7/1860mazindolobesityanorexiant |
| spellingShingle | Yoshimitsu Tanaka Norikazu Maeda Masahiro Koseki Kazuhisa Maeda Changes in Body Weight in Severely Obese Patients Treated with the Anorexiant Mazindol Journal of Clinical Medicine mazindol obesity anorexiant |
| title | Changes in Body Weight in Severely Obese Patients Treated with the Anorexiant Mazindol |
| title_full | Changes in Body Weight in Severely Obese Patients Treated with the Anorexiant Mazindol |
| title_fullStr | Changes in Body Weight in Severely Obese Patients Treated with the Anorexiant Mazindol |
| title_full_unstemmed | Changes in Body Weight in Severely Obese Patients Treated with the Anorexiant Mazindol |
| title_short | Changes in Body Weight in Severely Obese Patients Treated with the Anorexiant Mazindol |
| title_sort | changes in body weight in severely obese patients treated with the anorexiant mazindol |
| topic | mazindol obesity anorexiant |
| url | https://www.mdpi.com/2077-0383/13/7/1860 |
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