The Association between Oxidative Balance Score and Urinary Levels of 8-Hydroxydeoxyguanosine among Japanese Adults
The oxidative balance score (OBS), wherein higher OBSs indicate lower oxidative stress, was designed to assess a composite measure of multiple pro-oxidant and antioxidant effects on an individual’s oxidative stress status. This study aimed to evaluate whether OBSs were inversely associated with urin...
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MDPI AG
2023-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/21/4533 |
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| author | Hinako Nanri Megumi Hara Yuichiro Nishida Chisato Shimanoe Yun-Shan Li Hiroshi Kasai Kazuaki Kawai Yasuki Higaki Keitaro Tanaka |
| author_facet | Hinako Nanri Megumi Hara Yuichiro Nishida Chisato Shimanoe Yun-Shan Li Hiroshi Kasai Kazuaki Kawai Yasuki Higaki Keitaro Tanaka |
| author_sort | Hinako Nanri |
| collection | DOAJ |
| description | The oxidative balance score (OBS), wherein higher OBSs indicate lower oxidative stress, was designed to assess a composite measure of multiple pro-oxidant and antioxidant effects on an individual’s oxidative stress status. This study aimed to evaluate whether OBSs were inversely associated with urinary levels of 8-hydroxydeoxyguanosine (8-OHdG)–an oxidative stress marker–among Japanese adults. This cross-sectional study was based on data obtained during 2010–2012. Overall, 7552 participants from the J-MICC Study Saga who answered a self-administered food frequency questionnaire were recruited for the final analysis. OBSs were calculated from 11 pro-oxidant and antioxidant lifestyle factors, including dietary intake, physical activity, and alcohol and smoking status. Urinary 8-OHdG values were corrected by creatinine level (ng/mg creatinine). Our findings revealed a higher total OBS was significantly associated with lower urinary 8-OHdG/creatinine levels after adjustment for covariates in men and women (<i>p</i> for trend < 0.01 in both sexes). We performed a multiple regression analysis of the association between OBSs and urinary 8-OHdG/creatinine levels stratified by age, body mass index (BMI), and menopausal status and found consistent negative associations in most groups for both sexes. No significant differences in the 60–64 age group for women (standardized <i>β</i> = −0.09, <i>p</i> = 0.13) or BMI < 18.5 kg/m<sup>2</sup> for men (standardized <i>β</i> = −0.18, <i>p</i> = 0.17) were observed. A higher OBS had a strong inverse association with urinary 8-OHdG/creatinine levels in men and women among Japanese adults. The OBS might be a useful tool for evaluating the roles of oxidative stress-related lifestyle factors, including diet. |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T11:24:07Z |
| publishDate | 2023-10-01 |
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| spelling | doaj.art-37fb89a6002f4b719808ef2692b8b4fa2023-11-10T15:09:31ZengMDPI AGNutrients2072-66432023-10-011521453310.3390/nu15214533The Association between Oxidative Balance Score and Urinary Levels of 8-Hydroxydeoxyguanosine among Japanese AdultsHinako Nanri0Megumi Hara1Yuichiro Nishida2Chisato Shimanoe3Yun-Shan Li4Hiroshi Kasai5Kazuaki Kawai6Yasuki Higaki7Keitaro Tanaka8Department of Physical Activity Research, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka 566-0002, JapanDepartment of Preventive Medicine, Faculty of Medicine, Saga University, Saga 849-8501, JapanDepartment of Preventive Medicine, Faculty of Medicine, Saga University, Saga 849-8501, JapanDepartment of Pharmacy, Saga University Hospital, Saga 849-8501, JapanDepartment of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu 807-8555, JapanDepartment of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu 807-8555, JapanDepartment of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu 807-8555, JapanLaboratory of Exercise Physiology, Faculty of Sports and Health Science, Fukuoka University, Fukuoka 814-0180, JapanDepartment of Preventive Medicine, Faculty of Medicine, Saga University, Saga 849-8501, JapanThe oxidative balance score (OBS), wherein higher OBSs indicate lower oxidative stress, was designed to assess a composite measure of multiple pro-oxidant and antioxidant effects on an individual’s oxidative stress status. This study aimed to evaluate whether OBSs were inversely associated with urinary levels of 8-hydroxydeoxyguanosine (8-OHdG)–an oxidative stress marker–among Japanese adults. This cross-sectional study was based on data obtained during 2010–2012. Overall, 7552 participants from the J-MICC Study Saga who answered a self-administered food frequency questionnaire were recruited for the final analysis. OBSs were calculated from 11 pro-oxidant and antioxidant lifestyle factors, including dietary intake, physical activity, and alcohol and smoking status. Urinary 8-OHdG values were corrected by creatinine level (ng/mg creatinine). Our findings revealed a higher total OBS was significantly associated with lower urinary 8-OHdG/creatinine levels after adjustment for covariates in men and women (<i>p</i> for trend < 0.01 in both sexes). We performed a multiple regression analysis of the association between OBSs and urinary 8-OHdG/creatinine levels stratified by age, body mass index (BMI), and menopausal status and found consistent negative associations in most groups for both sexes. No significant differences in the 60–64 age group for women (standardized <i>β</i> = −0.09, <i>p</i> = 0.13) or BMI < 18.5 kg/m<sup>2</sup> for men (standardized <i>β</i> = −0.18, <i>p</i> = 0.17) were observed. A higher OBS had a strong inverse association with urinary 8-OHdG/creatinine levels in men and women among Japanese adults. The OBS might be a useful tool for evaluating the roles of oxidative stress-related lifestyle factors, including diet.https://www.mdpi.com/2072-6643/15/21/4533oxidative balance scoreantioxidanturinary 8-OHdGJapanese |
| spellingShingle | Hinako Nanri Megumi Hara Yuichiro Nishida Chisato Shimanoe Yun-Shan Li Hiroshi Kasai Kazuaki Kawai Yasuki Higaki Keitaro Tanaka The Association between Oxidative Balance Score and Urinary Levels of 8-Hydroxydeoxyguanosine among Japanese Adults Nutrients oxidative balance score antioxidant urinary 8-OHdG Japanese |
| title | The Association between Oxidative Balance Score and Urinary Levels of 8-Hydroxydeoxyguanosine among Japanese Adults |
| title_full | The Association between Oxidative Balance Score and Urinary Levels of 8-Hydroxydeoxyguanosine among Japanese Adults |
| title_fullStr | The Association between Oxidative Balance Score and Urinary Levels of 8-Hydroxydeoxyguanosine among Japanese Adults |
| title_full_unstemmed | The Association between Oxidative Balance Score and Urinary Levels of 8-Hydroxydeoxyguanosine among Japanese Adults |
| title_short | The Association between Oxidative Balance Score and Urinary Levels of 8-Hydroxydeoxyguanosine among Japanese Adults |
| title_sort | association between oxidative balance score and urinary levels of 8 hydroxydeoxyguanosine among japanese adults |
| topic | oxidative balance score antioxidant urinary 8-OHdG Japanese |
| url | https://www.mdpi.com/2072-6643/15/21/4533 |
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