Outcomes of stable and unstable patterns of subjective cognitive decline – results from the Leipzig Longitudinal Study of the Aged (LEILA75+)
Abstract Background Subjective cognitive decline (SCD), i.e., the self-perceived feeling of worsening cognitive function, may be the first notable syndrome of preclinical Alzheimer’s disease and other dementias. However, not all individuals with SCD progress. Stability of SCD, i.e., repeated reports...
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| Format: | Article |
| Language: | English |
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BMC
2016-11-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12877-016-0353-8 |
| _version_ | 1818115113948807168 |
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| author | Susanne Roehr Arno Villringer Matthias C. Angermeyer Tobias Luck Steffi G. Riedel-Heller |
| author_facet | Susanne Roehr Arno Villringer Matthias C. Angermeyer Tobias Luck Steffi G. Riedel-Heller |
| author_sort | Susanne Roehr |
| collection | DOAJ |
| description | Abstract Background Subjective cognitive decline (SCD), i.e., the self-perceived feeling of worsening cognitive function, may be the first notable syndrome of preclinical Alzheimer’s disease and other dementias. However, not all individuals with SCD progress. Stability of SCD, i.e., repeated reports of SCD, could contribute to identify individuals at risk, as stable SCD may more likely reflect the continuous neurodegenerative process of Alzheimer’s and other dementias. Methods Cox regression analyses were used to assess the association between stability of SCD and progression to MCI and dementia in data derived from the population-based Leipzig Longitudinal Study of the Aged (LEILA75+). Results Of 453 cognitively unimpaired individuals with a mean age of 80.5 years (SD = 4.2), 139 (30.7 %) reported SCD at baseline. Over the study period (M = 4.8 years, SD = 2.2), 84 (18.5 %) individuals had stable SCD, 195 (43.1 %) unstable SCD and 174 (38.4 %) never reported SCD. Stable SCD was associated with increased risk of progression to MCI and dementia (unadjusted HR = 1.8, 95 % CI = 1.2–2.6; p < .01), whereas unstable SCD yielded a decreased progression risk (unadjusted HR = 0.5, 95 % CI = 0.4–0.7; p < .001) compared to no SCD. When adjusted for baseline cognitive functioning, progression risk in individuals with stable SCD was significantly increased in comparison to individuals with unstable SCD, but not compared to individuals without SCD. Conclusions Our results, though preliminary, suggest that stable SCD, i.e., repeated reports of SCD, may yield an increased risk of progression to MCI and dementia compared to unstable SCD. Baseline cognitive scores, though within a normal range, seem to be a driver of progression in stable SCD. Future research is warranted to investigate whether stability could hold as a SCD research feature. |
| first_indexed | 2024-12-11T04:01:28Z |
| format | Article |
| id | doaj.art-37fb9f07fbff4dafbde45c241eaf4cea |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-12-11T04:01:28Z |
| publishDate | 2016-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-37fb9f07fbff4dafbde45c241eaf4cea2022-12-22T01:21:38ZengBMCBMC Geriatrics1471-23182016-11-011611810.1186/s12877-016-0353-8Outcomes of stable and unstable patterns of subjective cognitive decline – results from the Leipzig Longitudinal Study of the Aged (LEILA75+)Susanne Roehr0Arno Villringer1Matthias C. Angermeyer2Tobias Luck3Steffi G. Riedel-Heller4Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of LeipzigMax Planck Institute for Human Cognitive and Brain SciencesCenter for Public Mental HealthInstitute of Social Medicine, Occupational Health and Public Health (ISAP), University of LeipzigInstitute of Social Medicine, Occupational Health and Public Health (ISAP), University of LeipzigAbstract Background Subjective cognitive decline (SCD), i.e., the self-perceived feeling of worsening cognitive function, may be the first notable syndrome of preclinical Alzheimer’s disease and other dementias. However, not all individuals with SCD progress. Stability of SCD, i.e., repeated reports of SCD, could contribute to identify individuals at risk, as stable SCD may more likely reflect the continuous neurodegenerative process of Alzheimer’s and other dementias. Methods Cox regression analyses were used to assess the association between stability of SCD and progression to MCI and dementia in data derived from the population-based Leipzig Longitudinal Study of the Aged (LEILA75+). Results Of 453 cognitively unimpaired individuals with a mean age of 80.5 years (SD = 4.2), 139 (30.7 %) reported SCD at baseline. Over the study period (M = 4.8 years, SD = 2.2), 84 (18.5 %) individuals had stable SCD, 195 (43.1 %) unstable SCD and 174 (38.4 %) never reported SCD. Stable SCD was associated with increased risk of progression to MCI and dementia (unadjusted HR = 1.8, 95 % CI = 1.2–2.6; p < .01), whereas unstable SCD yielded a decreased progression risk (unadjusted HR = 0.5, 95 % CI = 0.4–0.7; p < .001) compared to no SCD. When adjusted for baseline cognitive functioning, progression risk in individuals with stable SCD was significantly increased in comparison to individuals with unstable SCD, but not compared to individuals without SCD. Conclusions Our results, though preliminary, suggest that stable SCD, i.e., repeated reports of SCD, may yield an increased risk of progression to MCI and dementia compared to unstable SCD. Baseline cognitive scores, though within a normal range, seem to be a driver of progression in stable SCD. Future research is warranted to investigate whether stability could hold as a SCD research feature.http://link.springer.com/article/10.1186/s12877-016-0353-8Subjective cognitive declineMild cognitive impairmentDementiaAlzheimer’s diseaseProgression riskCohort studies |
| spellingShingle | Susanne Roehr Arno Villringer Matthias C. Angermeyer Tobias Luck Steffi G. Riedel-Heller Outcomes of stable and unstable patterns of subjective cognitive decline – results from the Leipzig Longitudinal Study of the Aged (LEILA75+) BMC Geriatrics Subjective cognitive decline Mild cognitive impairment Dementia Alzheimer’s disease Progression risk Cohort studies |
| title | Outcomes of stable and unstable patterns of subjective cognitive decline – results from the Leipzig Longitudinal Study of the Aged (LEILA75+) |
| title_full | Outcomes of stable and unstable patterns of subjective cognitive decline – results from the Leipzig Longitudinal Study of the Aged (LEILA75+) |
| title_fullStr | Outcomes of stable and unstable patterns of subjective cognitive decline – results from the Leipzig Longitudinal Study of the Aged (LEILA75+) |
| title_full_unstemmed | Outcomes of stable and unstable patterns of subjective cognitive decline – results from the Leipzig Longitudinal Study of the Aged (LEILA75+) |
| title_short | Outcomes of stable and unstable patterns of subjective cognitive decline – results from the Leipzig Longitudinal Study of the Aged (LEILA75+) |
| title_sort | outcomes of stable and unstable patterns of subjective cognitive decline results from the leipzig longitudinal study of the aged leila75 |
| topic | Subjective cognitive decline Mild cognitive impairment Dementia Alzheimer’s disease Progression risk Cohort studies |
| url | http://link.springer.com/article/10.1186/s12877-016-0353-8 |
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