Eradication of HIV-1 latent reservoirs through therapeutic vaccination
Abstract Despite the significant success of combination anti-retroviral therapy to reduce HIV viremia and save lives, HIV-1 infection remains a lifelong infection that must be appropriately managed. Advances in the understanding of the HIV infection process and insights from vaccine development in o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-09-01
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| Series: | AIDS Research and Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12981-017-0177-4 |
| _version_ | 1811282871439065088 |
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| author | Joshua Pankrac Katja Klein Jamie F. S. Mann |
| author_facet | Joshua Pankrac Katja Klein Jamie F. S. Mann |
| author_sort | Joshua Pankrac |
| collection | DOAJ |
| description | Abstract Despite the significant success of combination anti-retroviral therapy to reduce HIV viremia and save lives, HIV-1 infection remains a lifelong infection that must be appropriately managed. Advances in the understanding of the HIV infection process and insights from vaccine development in other biomedical fields such as cancer, imaging, and genetic engineering have fueled rapid advancements in HIV cure research. In the last few years, several studies have focused on the development of “Kick and Kill” therapies to reverse HIV latency and kick start viral translational activity. This has been done with the aim that concomitant anti-retroviral treatment and the elicited immune responses will prevent de novo infections while eradicating productively infected cells. In this review, we describe our perspective on HIV cure and the new approaches we are undertaking to eradicate the established pro-viral reservoir. |
| first_indexed | 2024-04-13T02:00:16Z |
| format | Article |
| id | doaj.art-37fbc43182b14174ac93b133d136c6d3 |
| institution | Directory Open Access Journal |
| issn | 1742-6405 |
| language | English |
| last_indexed | 2024-04-13T02:00:16Z |
| publishDate | 2017-09-01 |
| publisher | BMC |
| record_format | Article |
| series | AIDS Research and Therapy |
| spelling | doaj.art-37fbc43182b14174ac93b133d136c6d32022-12-22T03:07:39ZengBMCAIDS Research and Therapy1742-64052017-09-011411410.1186/s12981-017-0177-4Eradication of HIV-1 latent reservoirs through therapeutic vaccinationJoshua Pankrac0Katja Klein1Jamie F. S. Mann2Department of Microbiology and Immunology, University of Western OntarioDepartment of Microbiology and Immunology, University of Western OntarioDepartment of Microbiology and Immunology, University of Western OntarioAbstract Despite the significant success of combination anti-retroviral therapy to reduce HIV viremia and save lives, HIV-1 infection remains a lifelong infection that must be appropriately managed. Advances in the understanding of the HIV infection process and insights from vaccine development in other biomedical fields such as cancer, imaging, and genetic engineering have fueled rapid advancements in HIV cure research. In the last few years, several studies have focused on the development of “Kick and Kill” therapies to reverse HIV latency and kick start viral translational activity. This has been done with the aim that concomitant anti-retroviral treatment and the elicited immune responses will prevent de novo infections while eradicating productively infected cells. In this review, we describe our perspective on HIV cure and the new approaches we are undertaking to eradicate the established pro-viral reservoir.http://link.springer.com/article/10.1186/s12981-017-0177-4HIV-1LatencyCureVLPsCD4 T cells |
| spellingShingle | Joshua Pankrac Katja Klein Jamie F. S. Mann Eradication of HIV-1 latent reservoirs through therapeutic vaccination AIDS Research and Therapy HIV-1 Latency Cure VLPs CD4 T cells |
| title | Eradication of HIV-1 latent reservoirs through therapeutic vaccination |
| title_full | Eradication of HIV-1 latent reservoirs through therapeutic vaccination |
| title_fullStr | Eradication of HIV-1 latent reservoirs through therapeutic vaccination |
| title_full_unstemmed | Eradication of HIV-1 latent reservoirs through therapeutic vaccination |
| title_short | Eradication of HIV-1 latent reservoirs through therapeutic vaccination |
| title_sort | eradication of hiv 1 latent reservoirs through therapeutic vaccination |
| topic | HIV-1 Latency Cure VLPs CD4 T cells |
| url | http://link.springer.com/article/10.1186/s12981-017-0177-4 |
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