Advanced glycation end products (AGEs) in relation to atherosclerotic lipid profiles in middle-aged and elderly diabetic patients
<p>Abstract</p> <p>Objectives</p> <p>To evaluate the association between AGEs and atherosclerotic lipid profiles among aging diabetic patients in Taiwan.</p> <p>Design and Methods</p> <p>After age and gender matching, we selected 207 diabetic sub...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-12-01
|
| Series: | Lipids in Health and Disease |
| Online Access: | http://www.lipidworld.com/content/10/1/228 |
| _version_ | 1818081670761283584 |
|---|---|
| author | Chang Jin-Biou Chu Nain-Feng Syu Jhu-Ting Hsieh An-Tsz Hung Yi-Ren |
| author_facet | Chang Jin-Biou Chu Nain-Feng Syu Jhu-Ting Hsieh An-Tsz Hung Yi-Ren |
| author_sort | Chang Jin-Biou |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Objectives</p> <p>To evaluate the association between AGEs and atherosclerotic lipid profiles among aging diabetic patients in Taiwan.</p> <p>Design and Methods</p> <p>After age and gender matching, we selected 207 diabetic subjects and 174 diabetic subjects with proteinuria. Lipid profiles, including total cholesterol (TC), triglycerides (TG), high density cholesterol-lipoprotein (HDL-C) and low density lipoprotein-cholesterol (LDL-C) were measured using standard methods. AGEs were measured with the immunoassay method.</p> <p>Results</p> <p>In general, males were heavier; however, females had higher AGEs, fasting glucose (GLU), TC, HDL-C and LDL-C levels than males, and had higher TC/HDL-C, LDL-C/HDL-C, and TG/HDL-C ratios compared to males. AGEs were more strongly correlated with TG levels and TCL/LDL-C, LDL-C/HDL-C and TG/HDL-C ratios when compared to glucose or hemoglobin A1c. Subjects had higher AGEs levels (≧ 2.0 AU) with more adverse lipid profiles.</p> <p>Conclusion</p> <p>AGEs seem to be a good biomarker to evaluate the association between diabetes and atherosclerotic disorders in aging diabetes.</p> |
| first_indexed | 2024-12-10T19:09:54Z |
| format | Article |
| id | doaj.art-37fc5be425784207b0e3bc4f7c841fce |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-10T19:09:54Z |
| publishDate | 2011-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-37fc5be425784207b0e3bc4f7c841fce2022-12-22T01:36:46ZengBMCLipids in Health and Disease1476-511X2011-12-0110122810.1186/1476-511X-10-228Advanced glycation end products (AGEs) in relation to atherosclerotic lipid profiles in middle-aged and elderly diabetic patientsChang Jin-BiouChu Nain-FengSyu Jhu-TingHsieh An-TszHung Yi-Ren<p>Abstract</p> <p>Objectives</p> <p>To evaluate the association between AGEs and atherosclerotic lipid profiles among aging diabetic patients in Taiwan.</p> <p>Design and Methods</p> <p>After age and gender matching, we selected 207 diabetic subjects and 174 diabetic subjects with proteinuria. Lipid profiles, including total cholesterol (TC), triglycerides (TG), high density cholesterol-lipoprotein (HDL-C) and low density lipoprotein-cholesterol (LDL-C) were measured using standard methods. AGEs were measured with the immunoassay method.</p> <p>Results</p> <p>In general, males were heavier; however, females had higher AGEs, fasting glucose (GLU), TC, HDL-C and LDL-C levels than males, and had higher TC/HDL-C, LDL-C/HDL-C, and TG/HDL-C ratios compared to males. AGEs were more strongly correlated with TG levels and TCL/LDL-C, LDL-C/HDL-C and TG/HDL-C ratios when compared to glucose or hemoglobin A1c. Subjects had higher AGEs levels (≧ 2.0 AU) with more adverse lipid profiles.</p> <p>Conclusion</p> <p>AGEs seem to be a good biomarker to evaluate the association between diabetes and atherosclerotic disorders in aging diabetes.</p>http://www.lipidworld.com/content/10/1/228 |
| spellingShingle | Chang Jin-Biou Chu Nain-Feng Syu Jhu-Ting Hsieh An-Tsz Hung Yi-Ren Advanced glycation end products (AGEs) in relation to atherosclerotic lipid profiles in middle-aged and elderly diabetic patients Lipids in Health and Disease |
| title | Advanced glycation end products (AGEs) in relation to atherosclerotic lipid profiles in middle-aged and elderly diabetic patients |
| title_full | Advanced glycation end products (AGEs) in relation to atherosclerotic lipid profiles in middle-aged and elderly diabetic patients |
| title_fullStr | Advanced glycation end products (AGEs) in relation to atherosclerotic lipid profiles in middle-aged and elderly diabetic patients |
| title_full_unstemmed | Advanced glycation end products (AGEs) in relation to atherosclerotic lipid profiles in middle-aged and elderly diabetic patients |
| title_short | Advanced glycation end products (AGEs) in relation to atherosclerotic lipid profiles in middle-aged and elderly diabetic patients |
| title_sort | advanced glycation end products ages in relation to atherosclerotic lipid profiles in middle aged and elderly diabetic patients |
| url | http://www.lipidworld.com/content/10/1/228 |
| work_keys_str_mv | AT changjinbiou advancedglycationendproductsagesinrelationtoatheroscleroticlipidprofilesinmiddleagedandelderlydiabeticpatients AT chunainfeng advancedglycationendproductsagesinrelationtoatheroscleroticlipidprofilesinmiddleagedandelderlydiabeticpatients AT syujhuting advancedglycationendproductsagesinrelationtoatheroscleroticlipidprofilesinmiddleagedandelderlydiabeticpatients AT hsiehantsz advancedglycationendproductsagesinrelationtoatheroscleroticlipidprofilesinmiddleagedandelderlydiabeticpatients AT hungyiren advancedglycationendproductsagesinrelationtoatheroscleroticlipidprofilesinmiddleagedandelderlydiabeticpatients |