Feasibility and Performance of Free-Hand Single-Photon Computed Tomography/Ultrasonography for Preoperative Parathyroid Adenoma Localization: A Pilot Study
The aim of this prospective pilot study was to evaluate the feasibility of a new hybrid imaging modality, free-hand single-photon computed tomography/ultrasonography (fhSPECT/US), for preoperative localization of parathyroid adenomas and to compare its performance with conventional ultrasonography a...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/13/2200 |
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| author | Mélanie Champendal Mario Jreige Marie Nicod Lalonde José A. Pires Jorge Maurice Matter Gerasimos P. Sykiotis John O. Prior |
| author_facet | Mélanie Champendal Mario Jreige Marie Nicod Lalonde José A. Pires Jorge Maurice Matter Gerasimos P. Sykiotis John O. Prior |
| author_sort | Mélanie Champendal |
| collection | DOAJ |
| description | The aim of this prospective pilot study was to evaluate the feasibility of a new hybrid imaging modality, free-hand single-photon computed tomography/ultrasonography (fhSPECT/US), for preoperative localization of parathyroid adenomas and to compare its performance with conventional ultrasonography and SPECT/CT. Twelve patients diagnosed with primary hyperparathyroidism underwent sequentially US and parathyroid scintigraphy, including SPECT/CT, followed by fhSPECT/US, allowing for real-time fusion between US and freehand-generated gamma-camera images. The fhSPECT/US detection rates were correlated with histopathology, when available, or with the imaging modality showing the most lesions. Based on a per patient analysis, the detection rate was significantly different when comparing SPECT/CT to fhSPECT/US (<i>p</i> = 0.03), and not significantly different when comparing SPECT/CT to US (<i>p</i> = 0.16) and US to fhSPECT/US (<i>p</i> = 0.08). Based on a per-lesion analysis, the detection rate of SPECT/CT was significantly higher than that of US (<i>p</i> = 0.01) and fhSEPCT/US (<i>p</i> = 0.003), and there was no significant difference in detection rate when comparing US to fhSPECT/US (<i>p</i> = 0.08). The main perceived limitations of fhSPECT/US in lesion detection were: (i) lesions localized at a depth ≥4.5 cm; (ii) imperfect image fusion due to tissue compression; (iii) limited spatial manipulation ability of the SPECT mobile camera handheld probe; and (iv) a wide spread of detected activity. In conclusion, clinical use of fhSPECT/US for localization of parathyroid adenomas is feasible, but shows lower sensitivity than conventional modalities and requires technical improvements. |
| first_indexed | 2024-03-11T01:43:49Z |
| format | Article |
| id | doaj.art-37ffe22f48ae417dbb8179460a169e3b |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T01:43:49Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-37ffe22f48ae417dbb8179460a169e3b2023-11-18T16:21:23ZengMDPI AGDiagnostics2075-44182023-06-011313220010.3390/diagnostics13132200Feasibility and Performance of Free-Hand Single-Photon Computed Tomography/Ultrasonography for Preoperative Parathyroid Adenoma Localization: A Pilot StudyMélanie Champendal0Mario Jreige1Marie Nicod Lalonde2José A. Pires Jorge3Maurice Matter4Gerasimos P. Sykiotis5John O. Prior6School of Health Sciences HESAV, HES-SO, University of Applied Sciences Western Switzerland, 1011 Lausanne, SwitzerlandNuclear Medicine and Molecular Imaging Department, Lausanne University Hospital (CHUV), University of Lausanne, 1011 Lausanne, SwitzerlandNuclear Medicine and Molecular Imaging Department, Lausanne University Hospital (CHUV), University of Lausanne, 1011 Lausanne, SwitzerlandSchool of Health Sciences HESAV, HES-SO, University of Applied Sciences Western Switzerland, 1011 Lausanne, SwitzerlandVisceral Surgery Department, Lausanne University Hospital (CHUV), University of Lausanne, 1011 Lausanne, SwitzerlandService of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital (CHUV), University of Lausanne, 1011 Lausanne, SwitzerlandNuclear Medicine and Molecular Imaging Department, Lausanne University Hospital (CHUV), University of Lausanne, 1011 Lausanne, SwitzerlandThe aim of this prospective pilot study was to evaluate the feasibility of a new hybrid imaging modality, free-hand single-photon computed tomography/ultrasonography (fhSPECT/US), for preoperative localization of parathyroid adenomas and to compare its performance with conventional ultrasonography and SPECT/CT. Twelve patients diagnosed with primary hyperparathyroidism underwent sequentially US and parathyroid scintigraphy, including SPECT/CT, followed by fhSPECT/US, allowing for real-time fusion between US and freehand-generated gamma-camera images. The fhSPECT/US detection rates were correlated with histopathology, when available, or with the imaging modality showing the most lesions. Based on a per patient analysis, the detection rate was significantly different when comparing SPECT/CT to fhSPECT/US (<i>p</i> = 0.03), and not significantly different when comparing SPECT/CT to US (<i>p</i> = 0.16) and US to fhSPECT/US (<i>p</i> = 0.08). Based on a per-lesion analysis, the detection rate of SPECT/CT was significantly higher than that of US (<i>p</i> = 0.01) and fhSEPCT/US (<i>p</i> = 0.003), and there was no significant difference in detection rate when comparing US to fhSPECT/US (<i>p</i> = 0.08). The main perceived limitations of fhSPECT/US in lesion detection were: (i) lesions localized at a depth ≥4.5 cm; (ii) imperfect image fusion due to tissue compression; (iii) limited spatial manipulation ability of the SPECT mobile camera handheld probe; and (iv) a wide spread of detected activity. In conclusion, clinical use of fhSPECT/US for localization of parathyroid adenomas is feasible, but shows lower sensitivity than conventional modalities and requires technical improvements.https://www.mdpi.com/2075-4418/13/13/2200hybrid imagingSPECT/CTUShandheld gamma cameraparathyroid adenomaprimary hyperparathyroidism |
| spellingShingle | Mélanie Champendal Mario Jreige Marie Nicod Lalonde José A. Pires Jorge Maurice Matter Gerasimos P. Sykiotis John O. Prior Feasibility and Performance of Free-Hand Single-Photon Computed Tomography/Ultrasonography for Preoperative Parathyroid Adenoma Localization: A Pilot Study Diagnostics hybrid imaging SPECT/CT US handheld gamma camera parathyroid adenoma primary hyperparathyroidism |
| title | Feasibility and Performance of Free-Hand Single-Photon Computed Tomography/Ultrasonography for Preoperative Parathyroid Adenoma Localization: A Pilot Study |
| title_full | Feasibility and Performance of Free-Hand Single-Photon Computed Tomography/Ultrasonography for Preoperative Parathyroid Adenoma Localization: A Pilot Study |
| title_fullStr | Feasibility and Performance of Free-Hand Single-Photon Computed Tomography/Ultrasonography for Preoperative Parathyroid Adenoma Localization: A Pilot Study |
| title_full_unstemmed | Feasibility and Performance of Free-Hand Single-Photon Computed Tomography/Ultrasonography for Preoperative Parathyroid Adenoma Localization: A Pilot Study |
| title_short | Feasibility and Performance of Free-Hand Single-Photon Computed Tomography/Ultrasonography for Preoperative Parathyroid Adenoma Localization: A Pilot Study |
| title_sort | feasibility and performance of free hand single photon computed tomography ultrasonography for preoperative parathyroid adenoma localization a pilot study |
| topic | hybrid imaging SPECT/CT US handheld gamma camera parathyroid adenoma primary hyperparathyroidism |
| url | https://www.mdpi.com/2075-4418/13/13/2200 |
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