Increased DNA damage in progression of COPD: a response by poly(ADP-ribose) polymerase-1.

Increased DNA damage in progression of COPD: a response by poly(ADP-ribose) polymerase-1.

Chronic oxidative stress (OS), a major mechanism of chronic obstructive pulmonary disease (COPD), may cause significant damage to DNA. Poly(ADP-ribose) polymerase (PARP)-1 is rapidly activated by OS-induced DNA lesions. However, the degree of DNA damage along with the evolution of COPD is unclear. I...

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Bibliographic Details
Main Authors: Ingrid Oit-Wiscombe, Laszlo Virag, Ursel Soomets, Alan Altraja
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3722143?pdf=render

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