Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight women
Background: This study aimed to investigate whether magnesium supplementation might affect serum magnesium, high sensitive C-reactive protein (hs-CRP), plasma fibrinogen, and interleukin 6 (IL-6) levels in healthy middle-aged overweight women. The relationships, if any, between serum magnesium and t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Journal of Research in Medical Sciences |
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| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2012;volume=17;issue=7;spage=607;epage=614;aulast=Moslehi |
| _version_ | 1828417094626050048 |
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| author | Nazanin Moslehi Mohammadreza Vafa Abbas Rahimi-Foroushani Banafsheh Golestan |
| author_facet | Nazanin Moslehi Mohammadreza Vafa Abbas Rahimi-Foroushani Banafsheh Golestan |
| author_sort | Nazanin Moslehi |
| collection | DOAJ |
| description | Background: This study aimed to investigate whether magnesium supplementation might affect serum magnesium, high sensitive C-reactive protein (hs-CRP), plasma fibrinogen, and interleukin 6 (IL-6) levels in healthy middle-aged overweight women. The relationships, if any, between serum magnesium and the inflammatory markers were also examined cross-sectionally in the entire participants at the beginning of the study. Materials and Methods: This double-blinded, placebo-controlled, randomized trial included 74 middle-aged overweight women. Participants were randomly assigned to receive either 250 mg magnesium as magnesium oxide or placebo daily for 8 weeks. Serum magnesium, hs-CRP, fibrinogen and IL-6 concentrations were measured before and after the intervention. Results: Serum magnesium was found to be inversely correlated with hs-CRP (r s =−0.22, P=0.05) in the entire participants at baseline. Serum hs-CRP declined significantly in both groups as compared with baseline values (median change=0.8 mg/L; P Magnesium= 0.03, P Placebo 0.001). Plasma fibrinogen decreased significantly, by 9%, in the magnesium group at the end of week 8 compared to baseline (P=0.001). Mean concentration of IL-6 was significantly increased in the magnesium group comparing the baseline value(P=0.001). However hs-CRP, fibrinogen and IL-6 levels at week 8 or any changes during the study were not statistically different between the two groups. Serum magnesium showed no significant changes in any groups. Conclusions: Serum magnesium had a significant inverse correlation with hs-CRP. In the present study, magnesium as magnesium oxide, 250 mg/day, for 8 weeks did not significantly attenuate inflammatory markers in the magnesium group as compared to the placebo. |
| first_indexed | 2024-12-10T14:14:12Z |
| format | Article |
| id | doaj.art-38017d663a2d4e6e86408ce5f2255d97 |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-10T14:14:12Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-38017d663a2d4e6e86408ce5f2255d972022-12-22T01:45:23ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362012-01-01177607614Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight womenNazanin MoslehiMohammadreza VafaAbbas Rahimi-ForoushaniBanafsheh GolestanBackground: This study aimed to investigate whether magnesium supplementation might affect serum magnesium, high sensitive C-reactive protein (hs-CRP), plasma fibrinogen, and interleukin 6 (IL-6) levels in healthy middle-aged overweight women. The relationships, if any, between serum magnesium and the inflammatory markers were also examined cross-sectionally in the entire participants at the beginning of the study. Materials and Methods: This double-blinded, placebo-controlled, randomized trial included 74 middle-aged overweight women. Participants were randomly assigned to receive either 250 mg magnesium as magnesium oxide or placebo daily for 8 weeks. Serum magnesium, hs-CRP, fibrinogen and IL-6 concentrations were measured before and after the intervention. Results: Serum magnesium was found to be inversely correlated with hs-CRP (r s =−0.22, P=0.05) in the entire participants at baseline. Serum hs-CRP declined significantly in both groups as compared with baseline values (median change=0.8 mg/L; P Magnesium= 0.03, P Placebo 0.001). Plasma fibrinogen decreased significantly, by 9%, in the magnesium group at the end of week 8 compared to baseline (P=0.001). Mean concentration of IL-6 was significantly increased in the magnesium group comparing the baseline value(P=0.001). However hs-CRP, fibrinogen and IL-6 levels at week 8 or any changes during the study were not statistically different between the two groups. Serum magnesium showed no significant changes in any groups. Conclusions: Serum magnesium had a significant inverse correlation with hs-CRP. In the present study, magnesium as magnesium oxide, 250 mg/day, for 8 weeks did not significantly attenuate inflammatory markers in the magnesium group as compared to the placebo.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2012;volume=17;issue=7;spage=607;epage=614;aulast=MoslehiMagnesiummiddle-aged womenoverweightIL-6hs-CRPsystemic inflammation |
| spellingShingle | Nazanin Moslehi Mohammadreza Vafa Abbas Rahimi-Foroushani Banafsheh Golestan Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight women Journal of Research in Medical Sciences Magnesium middle-aged women overweight IL-6 hs-CRP systemic inflammation |
| title | Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight women |
| title_full | Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight women |
| title_fullStr | Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight women |
| title_full_unstemmed | Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight women |
| title_short | Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight women |
| title_sort | effects of oral magnesium supplementation on inflammatory markers in middle aged overweight women |
| topic | Magnesium middle-aged women overweight IL-6 hs-CRP systemic inflammation |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2012;volume=17;issue=7;spage=607;epage=614;aulast=Moslehi |
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