Biomarkers in acute kidney injury
<p><strong>Background</strong>: acute renal injury is a clinical syndrome resulting from multiple etiologies, which becomes evident in the sudden loss of renal functions. The constant search for biomarkers for its diagnosis is aimed at its early detection and prevention.</p>&...
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| Format: | Article |
| Language: | Spanish |
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Universidad de Ciencias Médicas de Las Tunas
2020-03-01
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| Series: | Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta |
| Subjects: | |
| Online Access: | http://revzoilomarinello.sld.cu/index.php/zmv/article/view/1922 |
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| author | Zoraida Caridad González-Milán Sergio Orlando Escalona-González Alejandro Jarol Pavón-Rojas |
| author_facet | Zoraida Caridad González-Milán Sergio Orlando Escalona-González Alejandro Jarol Pavón-Rojas |
| author_sort | Zoraida Caridad González-Milán |
| collection | DOAJ |
| description | <p><strong>Background</strong>: acute renal injury is a clinical syndrome resulting from multiple etiologies, which becomes evident in the sudden loss of renal functions. The constant search for biomarkers for its diagnosis is aimed at its early detection and prevention.</p><p><strong>Objective</strong>: to describe biomarkers of acute renal injury, according to the most updated bibliography.</p><p><strong>Methods</strong>: a bibliographic review was carried out using as information resources the ones available through the Infomed network (PubMed, SciELO, Ebsco and Clinical Key), as well as the Google Academic search engine. 81 % of the consulted bibliography belonged to the last 5 years and 64 % to the last 3 years. The methods used in the study were analysis-synthesis, induction-deduction and historical-logical.</p><p><strong>Results</strong>: in order to overcome the limitations of traditional markers and achieve an accurate diagnosis, and therefore a less unfavorable prognosis, new biomarkers have been identified such as: the kidney injury molecule 1, neutrophil gelatinase-associated lipocalin, interleukin 18, combination of tissue metalloproteinase inhibitor 2 and insulin-like growth factor binding protein 7, urinary N-acetyl-β-glucosamidase, Na-H exchanger isoform-3, liver-type fatty acid binding protein 1, netrin 1, fibroblast growth factor 23 and glutathione S-transferase.</p><p><strong>Conclusions</strong>: acute renal injury is a common condition today. In the scientific literature there are abundant articles on the use of sensitive and specific serum and/or urinary biomarkers, very useful for establishing the early diagnosis of it.</p> |
| first_indexed | 2024-12-17T02:18:02Z |
| format | Article |
| id | doaj.art-3802a7e8804a42e797af47644892b734 |
| institution | Directory Open Access Journal |
| issn | 1029-3027 |
| language | Spanish |
| last_indexed | 2024-12-17T02:18:02Z |
| publishDate | 2020-03-01 |
| publisher | Universidad de Ciencias Médicas de Las Tunas |
| record_format | Article |
| series | Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta |
| spelling | doaj.art-3802a7e8804a42e797af47644892b7342022-12-21T22:07:19ZspaUniversidad de Ciencias Médicas de Las TunasRevista Electrónica Dr. Zoilo E. Marinello Vidaurreta1029-30272020-03-01452994Biomarkers in acute kidney injuryZoraida Caridad González-Milán0Sergio Orlando Escalona-González1Alejandro Jarol Pavón-Rojas2Hospital General Docente “Dr. Ernesto Guevara de la Serna”. Las Tunas. Universidad de Ciencias Médicas de Las Tunas. Las Tunas.Universidad de Ciencias Médicas de Las Tunas. Facultad de Ciencias Médicas “Dr. Zoilo Enrique Marinello Vidaurreta”. Las Tunas.Universidad de Ciencias Médicas de Las Tunas. Facultad de Ciencias Médicas “Dr. Zoilo Enrique Marinello Vidaurreta”. Las Tunas.<p><strong>Background</strong>: acute renal injury is a clinical syndrome resulting from multiple etiologies, which becomes evident in the sudden loss of renal functions. The constant search for biomarkers for its diagnosis is aimed at its early detection and prevention.</p><p><strong>Objective</strong>: to describe biomarkers of acute renal injury, according to the most updated bibliography.</p><p><strong>Methods</strong>: a bibliographic review was carried out using as information resources the ones available through the Infomed network (PubMed, SciELO, Ebsco and Clinical Key), as well as the Google Academic search engine. 81 % of the consulted bibliography belonged to the last 5 years and 64 % to the last 3 years. The methods used in the study were analysis-synthesis, induction-deduction and historical-logical.</p><p><strong>Results</strong>: in order to overcome the limitations of traditional markers and achieve an accurate diagnosis, and therefore a less unfavorable prognosis, new biomarkers have been identified such as: the kidney injury molecule 1, neutrophil gelatinase-associated lipocalin, interleukin 18, combination of tissue metalloproteinase inhibitor 2 and insulin-like growth factor binding protein 7, urinary N-acetyl-β-glucosamidase, Na-H exchanger isoform-3, liver-type fatty acid binding protein 1, netrin 1, fibroblast growth factor 23 and glutathione S-transferase.</p><p><strong>Conclusions</strong>: acute renal injury is a common condition today. In the scientific literature there are abundant articles on the use of sensitive and specific serum and/or urinary biomarkers, very useful for establishing the early diagnosis of it.</p>http://revzoilomarinello.sld.cu/index.php/zmv/article/view/1922acute kidney injurybiomarkersbiomedical researchearly diagnosis |
| spellingShingle | Zoraida Caridad González-Milán Sergio Orlando Escalona-González Alejandro Jarol Pavón-Rojas Biomarkers in acute kidney injury Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta acute kidney injury biomarkers biomedical research early diagnosis |
| title | Biomarkers in acute kidney injury |
| title_full | Biomarkers in acute kidney injury |
| title_fullStr | Biomarkers in acute kidney injury |
| title_full_unstemmed | Biomarkers in acute kidney injury |
| title_short | Biomarkers in acute kidney injury |
| title_sort | biomarkers in acute kidney injury |
| topic | acute kidney injury biomarkers biomedical research early diagnosis |
| url | http://revzoilomarinello.sld.cu/index.php/zmv/article/view/1922 |
| work_keys_str_mv | AT zoraidacaridadgonzalezmilan biomarkersinacutekidneyinjury AT sergioorlandoescalonagonzalez biomarkersinacutekidneyinjury AT alejandrojarolpavonrojas biomarkersinacutekidneyinjury |