Curcumin suppresses cell proliferation and reduces cholesterol absorption in Caco-2 cells by activating the TRPA1 channel

Curcumin suppresses cell proliferation and reduces cholesterol absorption in Caco-2 cells by activating the TRPA1 channel

Abstract Background Curcumin (Cur) is a bioactive dietary polyphenol of turmeric with various biological activities against several cancers. Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths. Intestinal cholesterol homeostasis is associated with CRC. Chemotherapy for CRC...

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Bibliographic Details
Main Authors: Si Qin, Qian Su, Xiang Li, Muqing Shao, Yindi Zhang, Fadong Yu, Yinxing Ni, Jian Zhong
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Lipids in Health and Disease
Subjects:
Cholesterol absorption
Curcumin
Caco-2 cells
NPC1L1
Proliferation
TRPA1
Online Access:https://doi.org/10.1186/s12944-022-01750-7

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