The effect of multispecies probiotics on cognitive reactivity to sad mood in patients with Crohn’s disease
Background: Gut microbiota could modulate brain functions and consequent behavior through gut-brain axis. We evaluated the impact of intestinal flora using probiotics in patients with Crohn’s disease (CD) on cognitive reactivity to sad mood. Method: Patients in Group 1 received multiple probiotics f...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-07-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464621000803 |
| _version_ | 1818663155308429312 |
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| author | Lipei Wu Fujun Shen Weiwei Wang Chunrun Qi Chunbin Wang Anquan Shang Shihai Xuan |
| author_facet | Lipei Wu Fujun Shen Weiwei Wang Chunrun Qi Chunbin Wang Anquan Shang Shihai Xuan |
| author_sort | Lipei Wu |
| collection | DOAJ |
| description | Background: Gut microbiota could modulate brain functions and consequent behavior through gut-brain axis. We evaluated the impact of intestinal flora using probiotics in patients with Crohn’s disease (CD) on cognitive reactivity to sad mood. Method: Patients in Group 1 received multiple probiotics followed by Chamomile capsules. Patients in Group 2 received Chamomile capsules followed by multiple probiotics. Patients accomplished the Leiden Index of Depression Sensitivity (LEIDS-r), Beck Depression Inventory (BDI) questionnaires after each cycle of cross-over treatment. Results: The baseline LEIDS-r in two groups did not have significant difference. After 3 weeks of treatment, patients in Group 1 had better LEIDS-r scores compared with patients in Group 2 (36.6 vs. 40.9, P = 0.012). After crossover, patients in Group 1 had worse LEIDS-r scores compared with patients in Group 2 (39.2 vs. 35.2, P = 0. 0.016). Conclusion: Probiotics have the tendency to improve cognitive reactivity to sad mood in CD patients. |
| first_indexed | 2024-12-17T05:12:21Z |
| format | Article |
| id | doaj.art-3803a818b6b94b1799a4f2d9c8b6cf60 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T05:12:21Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-3803a818b6b94b1799a4f2d9c8b6cf602022-12-21T22:02:13ZengElsevierJournal of Functional Foods1756-46462021-07-0182104431The effect of multispecies probiotics on cognitive reactivity to sad mood in patients with Crohn’s diseaseLipei Wu0Fujun Shen1Weiwei Wang2Chunrun Qi3Chunbin Wang4Anquan Shang5Shihai Xuan6Department of Laboratory Medicine, Dongtai People's Hospital & Dongtai Hospital of Nantong University, Yancheng 224200, PR ChinaDepartment of Oncology, Yancheng Hospital Affiliated to Medical College Of Southeast University & The Third People's Hospital Of Yancheng City, Yancheng 224001, PR ChinaDepartment of Pathology, Tinghu People's Hospital, Yancheng 224001, PR ChinaDepartment of Pathology, Tinghu People's Hospital, Yancheng 224001, PR ChinaDepartment of Oncology, Yancheng Hospital Affiliated to Medical College Of Southeast University & The Third People's Hospital Of Yancheng City, Yancheng 224001, PR China; Corresponding authors at: Department of Oncology, Yancheng Hospital Affiliated to Medical College Of Southeast University & The Third People's Hospital Of Yancheng City, NO. 2 Xindu West Road, Yancheng, 224001, PR China (C. Wang). Department of Laboratory Medicine, Dongtai People's Hospital & Tinghu People's Hospital & Shanghai Tongji Hospital, No. 389, Xincun Road, Shanghai 200060, PR China (A. Shang). Department of Laboratory Medicine, Dongtai People's Hospital & Dongtai Hospital of Nantong University, NO. 2 Kangfu West Road, Yancheng 224200, PR China (S. Xuan).Department of Laboratory Medicine, Dongtai People's Hospital & Dongtai Hospital of Nantong University, Yancheng 224200, PR China; Department of Pathology, Tinghu People's Hospital, Yancheng 224001, PR China; Department of Laboratory Medicine, Shanghai Tongji Hospital, Shanghai 200060, PR China; Corresponding authors at: Department of Oncology, Yancheng Hospital Affiliated to Medical College Of Southeast University & The Third People's Hospital Of Yancheng City, NO. 2 Xindu West Road, Yancheng, 224001, PR China (C. Wang). Department of Laboratory Medicine, Dongtai People's Hospital & Tinghu People's Hospital & Shanghai Tongji Hospital, No. 389, Xincun Road, Shanghai 200060, PR China (A. Shang). Department of Laboratory Medicine, Dongtai People's Hospital & Dongtai Hospital of Nantong University, NO. 2 Kangfu West Road, Yancheng 224200, PR China (S. Xuan).Department of Laboratory Medicine, Dongtai People's Hospital & Dongtai Hospital of Nantong University, Yancheng 224200, PR China; Corresponding authors at: Department of Oncology, Yancheng Hospital Affiliated to Medical College Of Southeast University & The Third People's Hospital Of Yancheng City, NO. 2 Xindu West Road, Yancheng, 224001, PR China (C. Wang). Department of Laboratory Medicine, Dongtai People's Hospital & Tinghu People's Hospital & Shanghai Tongji Hospital, No. 389, Xincun Road, Shanghai 200060, PR China (A. Shang). Department of Laboratory Medicine, Dongtai People's Hospital & Dongtai Hospital of Nantong University, NO. 2 Kangfu West Road, Yancheng 224200, PR China (S. Xuan).Background: Gut microbiota could modulate brain functions and consequent behavior through gut-brain axis. We evaluated the impact of intestinal flora using probiotics in patients with Crohn’s disease (CD) on cognitive reactivity to sad mood. Method: Patients in Group 1 received multiple probiotics followed by Chamomile capsules. Patients in Group 2 received Chamomile capsules followed by multiple probiotics. Patients accomplished the Leiden Index of Depression Sensitivity (LEIDS-r), Beck Depression Inventory (BDI) questionnaires after each cycle of cross-over treatment. Results: The baseline LEIDS-r in two groups did not have significant difference. After 3 weeks of treatment, patients in Group 1 had better LEIDS-r scores compared with patients in Group 2 (36.6 vs. 40.9, P = 0.012). After crossover, patients in Group 1 had worse LEIDS-r scores compared with patients in Group 2 (39.2 vs. 35.2, P = 0. 0.016). Conclusion: Probiotics have the tendency to improve cognitive reactivity to sad mood in CD patients.http://www.sciencedirect.com/science/article/pii/S1756464621000803Crohn’s diseaseMicrobiotaProbioticsMental disordersDepression |
| spellingShingle | Lipei Wu Fujun Shen Weiwei Wang Chunrun Qi Chunbin Wang Anquan Shang Shihai Xuan The effect of multispecies probiotics on cognitive reactivity to sad mood in patients with Crohn’s disease Journal of Functional Foods Crohn’s disease Microbiota Probiotics Mental disorders Depression |
| title | The effect of multispecies probiotics on cognitive reactivity to sad mood in patients with Crohn’s disease |
| title_full | The effect of multispecies probiotics on cognitive reactivity to sad mood in patients with Crohn’s disease |
| title_fullStr | The effect of multispecies probiotics on cognitive reactivity to sad mood in patients with Crohn’s disease |
| title_full_unstemmed | The effect of multispecies probiotics on cognitive reactivity to sad mood in patients with Crohn’s disease |
| title_short | The effect of multispecies probiotics on cognitive reactivity to sad mood in patients with Crohn’s disease |
| title_sort | effect of multispecies probiotics on cognitive reactivity to sad mood in patients with crohn s disease |
| topic | Crohn’s disease Microbiota Probiotics Mental disorders Depression |
| url | http://www.sciencedirect.com/science/article/pii/S1756464621000803 |
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