PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading

PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading

The mammalian FBXL10-RNF68-RNF2 ubiquitin ligase complex (FRRUC) mono-ubiquitylates H2A at Lys119 to repress transcription in unstressed cells. We found that the FRRUC is rapidly and transiently recruited to sites of DNA damage in a PARP1- and TIMELESS-dependent manner to promote mono-ubiquitylation...

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Bibliographic Details
Main Authors: Gergely Rona, Domenico Roberti, Yandong Yin, Julia K Pagan, Harrison Homer, Elizabeth Sassani, Andras Zeke, Luca Busino, Eli Rothenberg, Michele Pagano
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
DNA damage response
DNA repair
FBXL10
RNF68
RNF2
BMI1
Online Access:https://elifesciences.org/articles/38771

Internet

https://elifesciences.org/articles/38771

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