Potential UV-Protective Effect of Freestanding Biodegradable Nanosheet-Based Sunscreen Preparations in <i>XPA</i>-Deficient Mice
Xeroderma pigmentosum (XP) is a rare autosomal recessive hereditary disorder. As patients with XP are deficient in nucleotide excision repair, they show severe photosensitivity symptoms. Although skin protection from ultraviolet (UV) radiation is essential to improve the life expectancy of such pati...
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| Format: | Article |
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MDPI AG
2022-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/2/431 |
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| author | Tomomi Hatanaka Khampeeraphan Ramphai Shun Takimoto Hiromi Kanda Nami Motosugi Minoru Kimura Tomotaka Mabuchi Midori Oyama Tomoharu Takeuchi Yosuke Okamura |
| author_facet | Tomomi Hatanaka Khampeeraphan Ramphai Shun Takimoto Hiromi Kanda Nami Motosugi Minoru Kimura Tomotaka Mabuchi Midori Oyama Tomoharu Takeuchi Yosuke Okamura |
| author_sort | Tomomi Hatanaka |
| collection | DOAJ |
| description | Xeroderma pigmentosum (XP) is a rare autosomal recessive hereditary disorder. As patients with XP are deficient in nucleotide excision repair, they show severe photosensitivity symptoms. Although skin protection from ultraviolet (UV) radiation is essential to improve the life expectancy of such patients, the optimal protective effect is not achieved even with sunscreen application, owing to the low usability of the preparations. Nanosheets are two-dimensional nanostructures with a thickness in the nanometer range. The extremely large aspect ratios of the nanosheets result in high transparency, flexibility, and adhesiveness. Moreover, their high moisture permeability enables their application to any area of the skin for a long time. We fabricated preparations containing avobenzone (BMDBM) based on freestanding poly (<span style="font-variant: small-caps;">L</span>-lactic acid) (PLLA) nanosheets through a spin-coating process. Although monolayered PLLA nanosheets did not contain enough BMDBM to protect against UV radiation, the layered nanosheets, consisting of five discrete BMDBM nanosheets, showed high UV absorbance without lowering the adhesive strength against skin. Inflammatory reactions in <i>XPA</i>-deficient mice after UV radiation were completely suppressed by the application of BMDBM-layered nanosheets to the skin. Thus, the BMDBM layered nanosheet could serve as a potential sunscreen preparation to improve the quality of life of patients with XP. |
| first_indexed | 2024-03-09T21:13:47Z |
| format | Article |
| id | doaj.art-38054268e43c42d1a86a978a9aabf578 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T21:13:47Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-38054268e43c42d1a86a978a9aabf5782023-11-23T21:39:14ZengMDPI AGPharmaceutics1999-49232022-02-0114243110.3390/pharmaceutics14020431Potential UV-Protective Effect of Freestanding Biodegradable Nanosheet-Based Sunscreen Preparations in <i>XPA</i>-Deficient MiceTomomi Hatanaka0Khampeeraphan Ramphai1Shun Takimoto2Hiromi Kanda3Nami Motosugi4Minoru Kimura5Tomotaka Mabuchi6Midori Oyama7Tomoharu Takeuchi8Yosuke Okamura9School of Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado 350-0295, JapanDepartment of Applied Chemistry, School of Engineering, Tokai University, 4-1-1 Kitakaname, Hiratsuka 259-1292, JapanCourse of Applied Science, Graduate School of Engineering, Tokai University, 4-1-1 Kitakaname, Hiratsuka 259-1292, JapanCourse of Applied Science, Graduate School of Engineering, Tokai University, 4-1-1 Kitakaname, Hiratsuka 259-1292, JapanFaculty of Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, JapanThe Institute of Medical Sciences, Tokai University, 143 Shimokasuya, Isehara 259-1193, JapanFaculty of Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, JapanSchool of Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado 350-0295, JapanSchool of Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado 350-0295, JapanDepartment of Applied Chemistry, School of Engineering, Tokai University, 4-1-1 Kitakaname, Hiratsuka 259-1292, JapanXeroderma pigmentosum (XP) is a rare autosomal recessive hereditary disorder. As patients with XP are deficient in nucleotide excision repair, they show severe photosensitivity symptoms. Although skin protection from ultraviolet (UV) radiation is essential to improve the life expectancy of such patients, the optimal protective effect is not achieved even with sunscreen application, owing to the low usability of the preparations. Nanosheets are two-dimensional nanostructures with a thickness in the nanometer range. The extremely large aspect ratios of the nanosheets result in high transparency, flexibility, and adhesiveness. Moreover, their high moisture permeability enables their application to any area of the skin for a long time. We fabricated preparations containing avobenzone (BMDBM) based on freestanding poly (<span style="font-variant: small-caps;">L</span>-lactic acid) (PLLA) nanosheets through a spin-coating process. Although monolayered PLLA nanosheets did not contain enough BMDBM to protect against UV radiation, the layered nanosheets, consisting of five discrete BMDBM nanosheets, showed high UV absorbance without lowering the adhesive strength against skin. Inflammatory reactions in <i>XPA</i>-deficient mice after UV radiation were completely suppressed by the application of BMDBM-layered nanosheets to the skin. Thus, the BMDBM layered nanosheet could serve as a potential sunscreen preparation to improve the quality of life of patients with XP.https://www.mdpi.com/1999-4923/14/2/431xeroderma pigmentosumUV protectionnanosheetlayered nanosheetpoly (<span style="font-variant: small-caps">L</span>-lactic acid)avobenzone |
| spellingShingle | Tomomi Hatanaka Khampeeraphan Ramphai Shun Takimoto Hiromi Kanda Nami Motosugi Minoru Kimura Tomotaka Mabuchi Midori Oyama Tomoharu Takeuchi Yosuke Okamura Potential UV-Protective Effect of Freestanding Biodegradable Nanosheet-Based Sunscreen Preparations in <i>XPA</i>-Deficient Mice Pharmaceutics xeroderma pigmentosum UV protection nanosheet layered nanosheet poly (<span style="font-variant: small-caps">L</span>-lactic acid) avobenzone |
| title | Potential UV-Protective Effect of Freestanding Biodegradable Nanosheet-Based Sunscreen Preparations in <i>XPA</i>-Deficient Mice |
| title_full | Potential UV-Protective Effect of Freestanding Biodegradable Nanosheet-Based Sunscreen Preparations in <i>XPA</i>-Deficient Mice |
| title_fullStr | Potential UV-Protective Effect of Freestanding Biodegradable Nanosheet-Based Sunscreen Preparations in <i>XPA</i>-Deficient Mice |
| title_full_unstemmed | Potential UV-Protective Effect of Freestanding Biodegradable Nanosheet-Based Sunscreen Preparations in <i>XPA</i>-Deficient Mice |
| title_short | Potential UV-Protective Effect of Freestanding Biodegradable Nanosheet-Based Sunscreen Preparations in <i>XPA</i>-Deficient Mice |
| title_sort | potential uv protective effect of freestanding biodegradable nanosheet based sunscreen preparations in i xpa i deficient mice |
| topic | xeroderma pigmentosum UV protection nanosheet layered nanosheet poly (<span style="font-variant: small-caps">L</span>-lactic acid) avobenzone |
| url | https://www.mdpi.com/1999-4923/14/2/431 |
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