Visualization of thermal washout due to spatiotemporally heterogenous perfusion in the application of a model-based control algorithm for MR-HIFU mediated hyperthermia
Purpose This article will report results from the in-vivo application of a previously published model-predictive control algorithm for MR-HIFU hyperthermia. The purpose of the investigation was to test the controller’s in-vivo performance and behavior in the presence of heterogeneous perfusion. Mate...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/02656736.2021.1933616 |
| _version_ | 1819319812281597952 |
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| author | Lukas Christian Sebeke Pia Rademann Alexandra Claudia Maul Sin Yuin Yeo Juan Daniel Castillo Gómez Daniel A. Deenen Patrick Schmidt Bram de Jager W. P. M. H. Heemels Holger Grüll Edwin Heijman |
| author_facet | Lukas Christian Sebeke Pia Rademann Alexandra Claudia Maul Sin Yuin Yeo Juan Daniel Castillo Gómez Daniel A. Deenen Patrick Schmidt Bram de Jager W. P. M. H. Heemels Holger Grüll Edwin Heijman |
| author_sort | Lukas Christian Sebeke |
| collection | DOAJ |
| description | Purpose This article will report results from the in-vivo application of a previously published model-predictive control algorithm for MR-HIFU hyperthermia. The purpose of the investigation was to test the controller’s in-vivo performance and behavior in the presence of heterogeneous perfusion. Materials and methods Hyperthermia at 42°C was induced and maintained for up to 30 min in a circular section of a thermometry slice in the biceps femoris of German landrace pigs (n=5) using a commercial MR-HIFU system and a recently developed MPC algorithm. The heating power allocation was correlated with heat sink maps and contrast-enhanced MRI images. The temporal change in perfusion was estimated based on the power required to maintain hyperthermia. Results The controller performed well throughout the treatments with an absolute average tracking error of 0.27 ± 0.15 °C and an average difference of 1.25 ± 0.22 °C between and The MPC algorithm allocates additional heating power to sub-volumes with elevated heat sink effects, which are colocalized with blood vessels visible on contrast-enhanced MRI. The perfusion appeared to have increased by at least a factor of ∼1.86 on average. Conclusions The MPC controller generates temperature distributions with a narrow spectrum of voxel temperatures inside the target ROI despite the presence of spatiotemporally heterogeneous perfusion due to the rapid thermometry feedback available with MR-HIFU and the flexible allocation of heating power. The visualization of spatiotemporally heterogeneous perfusion presents new research opportunities for the investigation of stimulated perfusion in hypoxic tumor regions. |
| first_indexed | 2024-12-24T11:09:38Z |
| format | Article |
| id | doaj.art-3805ac2edbea4aeebc2e3d3b22cc34ac |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-12-24T11:09:38Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-3805ac2edbea4aeebc2e3d3b22cc34ac2022-12-21T16:58:32ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572021-01-013811174118710.1080/02656736.2021.19336161933616Visualization of thermal washout due to spatiotemporally heterogenous perfusion in the application of a model-based control algorithm for MR-HIFU mediated hyperthermiaLukas Christian Sebeke0Pia Rademann1Alexandra Claudia Maul2Sin Yuin Yeo3Juan Daniel Castillo Gómez4Daniel A. Deenen5Patrick Schmidt6Bram de Jager7W. P. M. H. Heemels8Holger Grüll9Edwin Heijman10University of Cologne, Faculty of Medicine and University Hospital of Cologne, Institute of Diagnostic and Interventional RadiologyUniversity of Cologne, Faculty of Medicine and University Hospital of Cologne, Experimental MedicineUniversity of Cologne, Faculty of Medicine and University Hospital of Cologne, Experimental MedicineUniversity of Cologne, Faculty of Medicine and University Hospital of Cologne, Institute of Diagnostic and Interventional RadiologyUniversity of Cologne, Faculty of Medicine and University Hospital of Cologne, Institute of Diagnostic and Interventional RadiologyEindhoven University of Technology, Department of Mechanical Engineering, Control Systems TechnologyUniversity of Cologne, Faculty of Medicine and University Hospital of Cologne, Institute of Diagnostic and Interventional RadiologyEindhoven University of Technology, Department of Mechanical Engineering, Control Systems TechnologyEindhoven University of Technology, Department of Mechanical Engineering, Control Systems TechnologyUniversity of Cologne, Faculty of Medicine and University Hospital of Cologne, Institute of Diagnostic and Interventional RadiologyUniversity of Cologne, Faculty of Medicine and University Hospital of Cologne, Institute of Diagnostic and Interventional RadiologyPurpose This article will report results from the in-vivo application of a previously published model-predictive control algorithm for MR-HIFU hyperthermia. The purpose of the investigation was to test the controller’s in-vivo performance and behavior in the presence of heterogeneous perfusion. Materials and methods Hyperthermia at 42°C was induced and maintained for up to 30 min in a circular section of a thermometry slice in the biceps femoris of German landrace pigs (n=5) using a commercial MR-HIFU system and a recently developed MPC algorithm. The heating power allocation was correlated with heat sink maps and contrast-enhanced MRI images. The temporal change in perfusion was estimated based on the power required to maintain hyperthermia. Results The controller performed well throughout the treatments with an absolute average tracking error of 0.27 ± 0.15 °C and an average difference of 1.25 ± 0.22 °C between and The MPC algorithm allocates additional heating power to sub-volumes with elevated heat sink effects, which are colocalized with blood vessels visible on contrast-enhanced MRI. The perfusion appeared to have increased by at least a factor of ∼1.86 on average. Conclusions The MPC controller generates temperature distributions with a narrow spectrum of voxel temperatures inside the target ROI despite the presence of spatiotemporally heterogeneous perfusion due to the rapid thermometry feedback available with MR-HIFU and the flexible allocation of heating power. The visualization of spatiotemporally heterogeneous perfusion presents new research opportunities for the investigation of stimulated perfusion in hypoxic tumor regions.http://dx.doi.org/10.1080/02656736.2021.1933616high intensity focused ultrasoundnoninvasive thermometrymodelingcontrol systems engineering/treatment optimizationphysiological effects of hyperthermia |
| spellingShingle | Lukas Christian Sebeke Pia Rademann Alexandra Claudia Maul Sin Yuin Yeo Juan Daniel Castillo Gómez Daniel A. Deenen Patrick Schmidt Bram de Jager W. P. M. H. Heemels Holger Grüll Edwin Heijman Visualization of thermal washout due to spatiotemporally heterogenous perfusion in the application of a model-based control algorithm for MR-HIFU mediated hyperthermia International Journal of Hyperthermia high intensity focused ultrasound noninvasive thermometry modeling control systems engineering/treatment optimization physiological effects of hyperthermia |
| title | Visualization of thermal washout due to spatiotemporally heterogenous perfusion in the application of a model-based control algorithm for MR-HIFU mediated hyperthermia |
| title_full | Visualization of thermal washout due to spatiotemporally heterogenous perfusion in the application of a model-based control algorithm for MR-HIFU mediated hyperthermia |
| title_fullStr | Visualization of thermal washout due to spatiotemporally heterogenous perfusion in the application of a model-based control algorithm for MR-HIFU mediated hyperthermia |
| title_full_unstemmed | Visualization of thermal washout due to spatiotemporally heterogenous perfusion in the application of a model-based control algorithm for MR-HIFU mediated hyperthermia |
| title_short | Visualization of thermal washout due to spatiotemporally heterogenous perfusion in the application of a model-based control algorithm for MR-HIFU mediated hyperthermia |
| title_sort | visualization of thermal washout due to spatiotemporally heterogenous perfusion in the application of a model based control algorithm for mr hifu mediated hyperthermia |
| topic | high intensity focused ultrasound noninvasive thermometry modeling control systems engineering/treatment optimization physiological effects of hyperthermia |
| url | http://dx.doi.org/10.1080/02656736.2021.1933616 |
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