Non-mucinous lepidic predominant adenocarcinoma presenting with extensive aerogenous spread
An extremely rare case of non-mucinous lepidic-predominant invasive adenocarcinoma (LPA) showing extensive aerogenous spread with a <em>pneumonic</em> <em>presentation</em> is reported. A 73-year-old woman was referred to our hospital because of an infiltrative shadow on ches...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2016-12-01
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| Series: | Rare Tumors |
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| Online Access: | http://www.pagepress.org/journals/index.php/rt/article/view/6580 |
| _version_ | 1818097010268438528 |
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| author | Yusuke Takanashi Shogo Tajima Masaru Tsukui Kazuya Shinmura Takamitsu Hayakawa Tsuyoshi Takahashi Hiroshi Neyatani Kazuhito Funai |
| author_facet | Yusuke Takanashi Shogo Tajima Masaru Tsukui Kazuya Shinmura Takamitsu Hayakawa Tsuyoshi Takahashi Hiroshi Neyatani Kazuhito Funai |
| author_sort | Yusuke Takanashi |
| collection | DOAJ |
| description | An extremely rare case of non-mucinous lepidic-predominant invasive adenocarcinoma (LPA) showing extensive aerogenous spread with a <em>pneumonic</em> <em>presentation</em> is reported. A 73-year-old woman was referred to our hospital because of an infiltrative shadow on chest xray. Chest computed tomography revealed extensive ground glass opacities in the right lower lobe, which was accompanied by infiltrative shadow with a <em>pneumonic presentation</em>. Invasive mucinous adenocarcinoma was presumed, and a partial resection of the right lower lobe was done. Histopathological examination revealed lepidic growth-predominant invasive adenocarcinoma with Clara type tumor cells, and there were innumerable aerogenous metastases also consisting of Clara cells. Because Alcian Blue and periodic acid-Schiff staining disclosed no mucus, the tumor was diagnosed as a non-mucinous LPA. The patient showed a poor response to 5 courses of pemetrexed, and she died one year after the diagnosis due to cancer progression. Nonmucinous LPA showed a rare presentation characterized by extensive aerogenous spread followed by a poor prognosis. |
| first_indexed | 2024-12-10T23:13:43Z |
| format | Article |
| id | doaj.art-3805b39c88da49809345e852e1c603ef |
| institution | Directory Open Access Journal |
| issn | 2036-3605 2036-3613 |
| language | English |
| last_indexed | 2024-12-10T23:13:43Z |
| publishDate | 2016-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Rare Tumors |
| spelling | doaj.art-3805b39c88da49809345e852e1c603ef2022-12-22T01:29:53ZengSAGE PublishingRare Tumors2036-36052036-36132016-12-018410.4081/rt.2016.65803586Non-mucinous lepidic predominant adenocarcinoma presenting with extensive aerogenous spreadYusuke Takanashi0Shogo Tajima1Masaru Tsukui2Kazuya Shinmura3Takamitsu Hayakawa4Tsuyoshi Takahashi5Hiroshi Neyatani6Kazuhito Funai7Department of Thoracic Surgery, Fujieda Municipal General Hospital, FujiedaDepartment of Pathology, Fujieda Municipal General HospitalDepartment of Respiratory Medicine, Fujieda Municipal General Hospital, FujiedaDepartment of Tumor Pathology, Hamamatsu University School of Medicine, HamamatsuDepartment of Thoracic Surgery, Fujieda Municipal General Hospital, FujiedaDepartment of Thoracic Surgery, Fujieda Municipal General Hospital, FujiedaDepartment of Thoracic Surgery, Fujieda Municipal General Hospital, FujiedaDepartments of Surgery 1, Hamamatsu University School of Medicine, HamamatsuAn extremely rare case of non-mucinous lepidic-predominant invasive adenocarcinoma (LPA) showing extensive aerogenous spread with a <em>pneumonic</em> <em>presentation</em> is reported. A 73-year-old woman was referred to our hospital because of an infiltrative shadow on chest xray. Chest computed tomography revealed extensive ground glass opacities in the right lower lobe, which was accompanied by infiltrative shadow with a <em>pneumonic presentation</em>. Invasive mucinous adenocarcinoma was presumed, and a partial resection of the right lower lobe was done. Histopathological examination revealed lepidic growth-predominant invasive adenocarcinoma with Clara type tumor cells, and there were innumerable aerogenous metastases also consisting of Clara cells. Because Alcian Blue and periodic acid-Schiff staining disclosed no mucus, the tumor was diagnosed as a non-mucinous LPA. The patient showed a poor response to 5 courses of pemetrexed, and she died one year after the diagnosis due to cancer progression. Nonmucinous LPA showed a rare presentation characterized by extensive aerogenous spread followed by a poor prognosis.http://www.pagepress.org/journals/index.php/rt/article/view/6580Non-mucinous lepidic-predominant adenocarcinomaAerogenous spreadInvasive mucinous adenocarcinoma |
| spellingShingle | Yusuke Takanashi Shogo Tajima Masaru Tsukui Kazuya Shinmura Takamitsu Hayakawa Tsuyoshi Takahashi Hiroshi Neyatani Kazuhito Funai Non-mucinous lepidic predominant adenocarcinoma presenting with extensive aerogenous spread Rare Tumors Non-mucinous lepidic-predominant adenocarcinoma Aerogenous spread Invasive mucinous adenocarcinoma |
| title | Non-mucinous lepidic predominant adenocarcinoma presenting with extensive aerogenous spread |
| title_full | Non-mucinous lepidic predominant adenocarcinoma presenting with extensive aerogenous spread |
| title_fullStr | Non-mucinous lepidic predominant adenocarcinoma presenting with extensive aerogenous spread |
| title_full_unstemmed | Non-mucinous lepidic predominant adenocarcinoma presenting with extensive aerogenous spread |
| title_short | Non-mucinous lepidic predominant adenocarcinoma presenting with extensive aerogenous spread |
| title_sort | non mucinous lepidic predominant adenocarcinoma presenting with extensive aerogenous spread |
| topic | Non-mucinous lepidic-predominant adenocarcinoma Aerogenous spread Invasive mucinous adenocarcinoma |
| url | http://www.pagepress.org/journals/index.php/rt/article/view/6580 |
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