Emergence of Compensatory Mutations Reveals the Importance of Electrostatic Interactions between HIV-1 Integrase and Genomic RNA

Emergence of Compensatory Mutations Reveals the Importance of Electrostatic Interactions between HIV-1 Integrase and Genomic RNA

ABSTRACT HIV-1 integrase (IN) has a noncatalytic function in virion maturation through its binding to the viral RNA genome (gRNA). Class II IN substitutions inhibit IN-gRNA binding and result in the formation of virions with aberrant morphologies marked by mislocalization of the gRNA between the cap...

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Bibliographic Details
Main Authors: Christian Shema Mugisha, Tung Dinh, Abhishek Kumar, Kasyap Tenneti, Jenna E. Eschbach, Keanu Davis, Robert Gifford, Mamuka Kvaratskhelia, Sebla B. Kutluay
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:mBio
Subjects:
HIV-1
integrase
protein-RNA interactions
virion maturation
virology
Online Access:https://journals.asm.org/doi/10.1128/mbio.00431-22

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