Prognostic impact of tumor size reduction assessed by magnetic resonance imaging after radiochemotherapy in patients with locally advanced cervical cancer
ObjectivePelvic magnetic resonance imaging (MRI) is a key exam used for the initial assessment of loco-regional involvement of cervical cancer. In patients with locally advanced cervical cancer, MRI is used to evaluate the early response to radiochemotherapy before image-guided brachytherapy, the pr...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1046087/full |
| _version_ | 1811213200479223808 |
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| author | Abel Cordoba Benedicte Durand Alexandre Escande Sophie Taieb Mariem Ben Haj Amor Marie Cecile Le Deley Andree Michel Florence Le Tinier Delphine Hudry Carlos Martinez Eric Leblanc Stephanie Becourt Cyril Abdedaim Lucie Bresson Eric Lartigau Xavier Mirabel Fabrice Narducci |
| author_facet | Abel Cordoba Benedicte Durand Alexandre Escande Sophie Taieb Mariem Ben Haj Amor Marie Cecile Le Deley Andree Michel Florence Le Tinier Delphine Hudry Carlos Martinez Eric Leblanc Stephanie Becourt Cyril Abdedaim Lucie Bresson Eric Lartigau Xavier Mirabel Fabrice Narducci |
| author_sort | Abel Cordoba |
| collection | DOAJ |
| description | ObjectivePelvic magnetic resonance imaging (MRI) is a key exam used for the initial assessment of loco-regional involvement of cervical cancer. In patients with locally advanced cervical cancer, MRI is used to evaluate the early response to radiochemotherapy before image-guided brachytherapy, the prognostic impact of which we aimed to study.MethodsPatients with locally advanced cervical cancer treated using concomitant radiochemotherapy followed by closure treatment between January 2010 and December 2015 were included in this study. Clinical, anatomopathological, radiological, therapeutic, and follow-up data were evaluated.ResultsAfter applying the inclusion and exclusion criteria to the initially chosen 310 patients, 232 were included for evaluation (median follow-up period, 5.3 years). The median age was 50 years (range, 25–83 years), and the median tumor size was 47.5 mm (range, 0–105 mm). Based on the International Federation of Gynaecology and Obstetrics classification system, 9 patients were in stage IB2; 20, IB3; 2, IIA; 63, IIB; 4, IIIA; 7, IIIB; and 127, IIIC1 or higher. The re-evaluation MRI was performed at the median dose of 55.5 Gy, and median reduction in tumor size was 55.2% (range, −20–100%). There was a difference between the disease-free and overall survival rates of the patients with a tumor response greater or lesser than 50%. The risk of recurrence or death reduced by 39% in patients with a tumor size reduction >50%. The overall 5-year survival rate of patients with a response greater and lesser than 50% were 77.7% and 61.5%, respectively. The 5-year disease-free survival rate for these two groups of patients were 68.8% and 51.5%, respectively.ConclusionOur study confirms the prognostic impact of tumor size reduction using MRI data obtained after radiochemotherapy in patients with locally advanced cervical cancer. |
| first_indexed | 2024-04-12T05:42:00Z |
| format | Article |
| id | doaj.art-3807379e9b244d51a91c9546c51d87f2 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T05:42:00Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-3807379e9b244d51a91c9546c51d87f22022-12-22T03:45:35ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-12-011210.3389/fonc.2022.10460871046087Prognostic impact of tumor size reduction assessed by magnetic resonance imaging after radiochemotherapy in patients with locally advanced cervical cancerAbel Cordoba0Benedicte Durand1Alexandre Escande2Sophie Taieb3Mariem Ben Haj Amor4Marie Cecile Le Deley5Andree Michel6Florence Le Tinier7Delphine Hudry8Carlos Martinez9Eric Leblanc10Stephanie Becourt11Cyril Abdedaim12Lucie Bresson13Eric Lartigau14Xavier Mirabel15Fabrice Narducci16Academic Radiotherapy Department, Oscar Lambret Center, Lille, FranceAcademic Radiotherapy Department, Oscar Lambret Center, Lille, FranceAcademic Radiotherapy Department, Oscar Lambret Center, Lille, FranceRadiology Department, Oscar Lambret Center, Lille, FranceRadiology Department, Oscar Lambret Center, Lille, FranceBiostatistics Department, Oscar Lambret Center, Lille, FranceBiostatistics Department, Oscar Lambret Center, Lille, FranceAcademic Radiotherapy Department, Oscar Lambret Center, Lille, FranceMedical Oncology Department, Oscar Lambret Center, Lille, FranceMedical Oncology Department, Oscar Lambret Center, Lille, FranceMedical Oncology Department, Oscar Lambret Center, Lille, FranceSurgical Oncology Department, Oscar Lambret Center, Lille, FranceSurgical Oncology Department, Oscar Lambret Center, Lille, FranceDepartment of Surgical Oncology, Polyclinique Henin Beaumont, Henin, FranceAcademic Radiotherapy Department, Oscar Lambret Center, Lille, FranceAcademic Radiotherapy Department, Oscar Lambret Center, Lille, FranceMedical Oncology Department, Oscar Lambret Center, Lille, FranceObjectivePelvic magnetic resonance imaging (MRI) is a key exam used for the initial assessment of loco-regional involvement of cervical cancer. In patients with locally advanced cervical cancer, MRI is used to evaluate the early response to radiochemotherapy before image-guided brachytherapy, the prognostic impact of which we aimed to study.MethodsPatients with locally advanced cervical cancer treated using concomitant radiochemotherapy followed by closure treatment between January 2010 and December 2015 were included in this study. Clinical, anatomopathological, radiological, therapeutic, and follow-up data were evaluated.ResultsAfter applying the inclusion and exclusion criteria to the initially chosen 310 patients, 232 were included for evaluation (median follow-up period, 5.3 years). The median age was 50 years (range, 25–83 years), and the median tumor size was 47.5 mm (range, 0–105 mm). Based on the International Federation of Gynaecology and Obstetrics classification system, 9 patients were in stage IB2; 20, IB3; 2, IIA; 63, IIB; 4, IIIA; 7, IIIB; and 127, IIIC1 or higher. The re-evaluation MRI was performed at the median dose of 55.5 Gy, and median reduction in tumor size was 55.2% (range, −20–100%). There was a difference between the disease-free and overall survival rates of the patients with a tumor response greater or lesser than 50%. The risk of recurrence or death reduced by 39% in patients with a tumor size reduction >50%. The overall 5-year survival rate of patients with a response greater and lesser than 50% were 77.7% and 61.5%, respectively. The 5-year disease-free survival rate for these two groups of patients were 68.8% and 51.5%, respectively.ConclusionOur study confirms the prognostic impact of tumor size reduction using MRI data obtained after radiochemotherapy in patients with locally advanced cervical cancer.https://www.frontiersin.org/articles/10.3389/fonc.2022.1046087/fulllocally advanced cervical cancertumor shrinkageMRIradiochemotherapybrachytherapy |
| spellingShingle | Abel Cordoba Benedicte Durand Alexandre Escande Sophie Taieb Mariem Ben Haj Amor Marie Cecile Le Deley Andree Michel Florence Le Tinier Delphine Hudry Carlos Martinez Eric Leblanc Stephanie Becourt Cyril Abdedaim Lucie Bresson Eric Lartigau Xavier Mirabel Fabrice Narducci Prognostic impact of tumor size reduction assessed by magnetic resonance imaging after radiochemotherapy in patients with locally advanced cervical cancer Frontiers in Oncology locally advanced cervical cancer tumor shrinkage MRI radiochemotherapy brachytherapy |
| title | Prognostic impact of tumor size reduction assessed by magnetic resonance imaging after radiochemotherapy in patients with locally advanced cervical cancer |
| title_full | Prognostic impact of tumor size reduction assessed by magnetic resonance imaging after radiochemotherapy in patients with locally advanced cervical cancer |
| title_fullStr | Prognostic impact of tumor size reduction assessed by magnetic resonance imaging after radiochemotherapy in patients with locally advanced cervical cancer |
| title_full_unstemmed | Prognostic impact of tumor size reduction assessed by magnetic resonance imaging after radiochemotherapy in patients with locally advanced cervical cancer |
| title_short | Prognostic impact of tumor size reduction assessed by magnetic resonance imaging after radiochemotherapy in patients with locally advanced cervical cancer |
| title_sort | prognostic impact of tumor size reduction assessed by magnetic resonance imaging after radiochemotherapy in patients with locally advanced cervical cancer |
| topic | locally advanced cervical cancer tumor shrinkage MRI radiochemotherapy brachytherapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1046087/full |
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