Brucella epidydimo-orchitis successfully treated with dual oral drug regimen: A case report with differential diagnoses of malignancy and tuberculosis
Brucellosis is a zoonotic disease caused by Brucella spp. When complicated, Brucella may affect any organ system, including the genitourinary system in the form of epidydimo-orchitis. Brucella orchitis is the second most common form of complicated brucellosis. The present case is for an adolescent w...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Radiology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043322005581 |
| _version_ | 1798036759621140480 |
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| author | Renad S. Nahas, PharmD Abdulsalam Alsulami, MD Manar O. Lashkar, PharmD, BCPS Abrar K. Thabit, PharmD, BCIDP |
| author_facet | Renad S. Nahas, PharmD Abdulsalam Alsulami, MD Manar O. Lashkar, PharmD, BCPS Abrar K. Thabit, PharmD, BCIDP |
| author_sort | Renad S. Nahas, PharmD |
| collection | DOAJ |
| description | Brucellosis is a zoonotic disease caused by Brucella spp. When complicated, Brucella may affect any organ system, including the genitourinary system in the form of epidydimo-orchitis. Brucella orchitis is the second most common form of complicated brucellosis. The present case is for an adolescent who is otherwise healthy but presented with right testicular pain. Ultrasound imaging showed heterogeneous enlarged right testis with large heterogeneous mass and central necrosis. α-fetoprotein was normal and β-human choriogonadotropin was negative. Malignancy and tuberculosis were excluded based on histopathology and microbiology of the tissue biopsy, respectively. The history of raw dairy consumption and positive serology for B. melitensis and B. abortus established the diagnosis of Brucella epidydimo-orchitis. Treatment was successful with doxycycline and rifampin for four weeks. In pediatrics, it is important to rule out malignancy and make every attempt to avoid orchidectomy by making necessary investigations and involving infectious diseases consultation. |
| first_indexed | 2024-04-11T21:17:23Z |
| format | Article |
| id | doaj.art-38074ef54d2940aebc204f3625b570f5 |
| institution | Directory Open Access Journal |
| issn | 1930-0433 |
| language | English |
| last_indexed | 2024-04-11T21:17:23Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj.art-38074ef54d2940aebc204f3625b570f52022-12-22T04:02:46ZengElsevierRadiology Case Reports1930-04332022-10-01171034853489Brucella epidydimo-orchitis successfully treated with dual oral drug regimen: A case report with differential diagnoses of malignancy and tuberculosisRenad S. Nahas, PharmD0Abdulsalam Alsulami, MD1Manar O. Lashkar, PharmD, BCPS2Abrar K. Thabit, PharmD, BCIDP3Pharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz University, 7027 Abdullah Alsulaiman St, Jeddah 22254-2265, Saudi ArabiaDepartment of Pediatrics, Faculty of Medicine, King Abdulaziz University, 7027 Abdullah Alsulaiman St, Jeddah 22254-2265, Saudi ArabiaPharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz University, 7027 Abdullah Alsulaiman St, Jeddah 22254-2265, Saudi ArabiaPharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz University, 7027 Abdullah Alsulaiman St, Jeddah 22254-2265, Saudi Arabia; Corresponding author.Brucellosis is a zoonotic disease caused by Brucella spp. When complicated, Brucella may affect any organ system, including the genitourinary system in the form of epidydimo-orchitis. Brucella orchitis is the second most common form of complicated brucellosis. The present case is for an adolescent who is otherwise healthy but presented with right testicular pain. Ultrasound imaging showed heterogeneous enlarged right testis with large heterogeneous mass and central necrosis. α-fetoprotein was normal and β-human choriogonadotropin was negative. Malignancy and tuberculosis were excluded based on histopathology and microbiology of the tissue biopsy, respectively. The history of raw dairy consumption and positive serology for B. melitensis and B. abortus established the diagnosis of Brucella epidydimo-orchitis. Treatment was successful with doxycycline and rifampin for four weeks. In pediatrics, it is important to rule out malignancy and make every attempt to avoid orchidectomy by making necessary investigations and involving infectious diseases consultation.http://www.sciencedirect.com/science/article/pii/S1930043322005581BrucellosisBrucella Epidydimo-orchitisBrucella orchitisTestisTesticles |
| spellingShingle | Renad S. Nahas, PharmD Abdulsalam Alsulami, MD Manar O. Lashkar, PharmD, BCPS Abrar K. Thabit, PharmD, BCIDP Brucella epidydimo-orchitis successfully treated with dual oral drug regimen: A case report with differential diagnoses of malignancy and tuberculosis Radiology Case Reports Brucellosis Brucella Epidydimo-orchitis Brucella orchitis Testis Testicles |
| title | Brucella epidydimo-orchitis successfully treated with dual oral drug regimen: A case report with differential diagnoses of malignancy and tuberculosis |
| title_full | Brucella epidydimo-orchitis successfully treated with dual oral drug regimen: A case report with differential diagnoses of malignancy and tuberculosis |
| title_fullStr | Brucella epidydimo-orchitis successfully treated with dual oral drug regimen: A case report with differential diagnoses of malignancy and tuberculosis |
| title_full_unstemmed | Brucella epidydimo-orchitis successfully treated with dual oral drug regimen: A case report with differential diagnoses of malignancy and tuberculosis |
| title_short | Brucella epidydimo-orchitis successfully treated with dual oral drug regimen: A case report with differential diagnoses of malignancy and tuberculosis |
| title_sort | brucella epidydimo orchitis successfully treated with dual oral drug regimen a case report with differential diagnoses of malignancy and tuberculosis |
| topic | Brucellosis Brucella Epidydimo-orchitis Brucella orchitis Testis Testicles |
| url | http://www.sciencedirect.com/science/article/pii/S1930043322005581 |
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