Nuclear functions of prefoldin
Prefoldin is a cochaperone, present in all eukaryotes, that cooperates with the chaperonin CCT. It is known mainly for its functional relevance in the cytoplasmic folding of actin and tubulin monomers during cytoskeleton assembly. However, both canonical and prefoldin-like subunits of this heterohex...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2014-01-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.140085 |
| _version_ | 1818342379710578688 |
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| author | Gonzalo Millán-Zambrano Sebastián Chávez |
| author_facet | Gonzalo Millán-Zambrano Sebastián Chávez |
| author_sort | Gonzalo Millán-Zambrano |
| collection | DOAJ |
| description | Prefoldin is a cochaperone, present in all eukaryotes, that cooperates with the chaperonin CCT. It is known mainly for its functional relevance in the cytoplasmic folding of actin and tubulin monomers during cytoskeleton assembly. However, both canonical and prefoldin-like subunits of this heterohexameric complex have also been found in the nucleus, and are functionally connected with nuclear processes in yeast and metazoa. Plant prefoldin has also been detected in the nucleus and physically associated with a gene regulator. In this review, we summarize the information available on the involvement of prefoldin in nuclear phenomena, place special emphasis on gene transcription, and discuss the possibility of a global coordination between gene regulation and cytoplasmic dynamics mediated by prefoldin. |
| first_indexed | 2024-12-13T16:13:45Z |
| format | Article |
| id | doaj.art-3809392d47e0469283047553fdcd76e0 |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-12-13T16:13:45Z |
| publishDate | 2014-01-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-3809392d47e0469283047553fdcd76e02022-12-21T23:38:52ZengThe Royal SocietyOpen Biology2046-24412014-01-014710.1098/rsob.140085140085Nuclear functions of prefoldinGonzalo Millán-ZambranoSebastián ChávezPrefoldin is a cochaperone, present in all eukaryotes, that cooperates with the chaperonin CCT. It is known mainly for its functional relevance in the cytoplasmic folding of actin and tubulin monomers during cytoskeleton assembly. However, both canonical and prefoldin-like subunits of this heterohexameric complex have also been found in the nucleus, and are functionally connected with nuclear processes in yeast and metazoa. Plant prefoldin has also been detected in the nucleus and physically associated with a gene regulator. In this review, we summarize the information available on the involvement of prefoldin in nuclear phenomena, place special emphasis on gene transcription, and discuss the possibility of a global coordination between gene regulation and cytoplasmic dynamics mediated by prefoldin.https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.140085prefoldingene transcriptioncytoskeletonchromatinprotein folding |
| spellingShingle | Gonzalo Millán-Zambrano Sebastián Chávez Nuclear functions of prefoldin Open Biology prefoldin gene transcription cytoskeleton chromatin protein folding |
| title | Nuclear functions of prefoldin |
| title_full | Nuclear functions of prefoldin |
| title_fullStr | Nuclear functions of prefoldin |
| title_full_unstemmed | Nuclear functions of prefoldin |
| title_short | Nuclear functions of prefoldin |
| title_sort | nuclear functions of prefoldin |
| topic | prefoldin gene transcription cytoskeleton chromatin protein folding |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.140085 |
| work_keys_str_mv | AT gonzalomillanzambrano nuclearfunctionsofprefoldin AT sebastianchavez nuclearfunctionsofprefoldin |