Inhibitory receptor signaling destabilizes immunological synapse formation in primary NK cells

Inhibitory receptor signaling destabilizes immunological synapse formation in primary NK cells

Upon engagement of their cognate class I major histocompatibility complex (MHC) ligands, receptors containing immunotyrosine-based inhibitory motifs (ITIMs) transduce signals that block cytolytic and inflammatory responses. In this manner, ITIM-coupled receptors play a crucial role in maintaining n...

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Bibliographic Details
Main Authors: Thushara P Abeyweera, Morgan eHuse, Molly eKaissar
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Immunology
Subjects:
Immunological Synapses
Signal Transduction
imaging
NK cell
ITIM
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00410/full

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