Analysis of Y Chromosome Microdeletion in Indonesian Males
The aim of this study is to find out Y chromosome microdeletion in Indonesian azoospermic men. This study used the PCR method with five STS to locate deletion on three different subregions (AZFa, AZFb, and AZFc) of azoospermic men and one STS to amplify SRY gen which act as an internal control. In t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universitas Indonesia
2010-10-01
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| Series: | Makara Journal of Health Research |
| Subjects: | |
| Online Access: | http://journal.ui.ac.id/index.php/health/article/view/165 |
| _version_ | 1797763405570899968 |
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| author | Dwi Anita Suryandari Yurnadi Yunardi Puji Sari |
| author_facet | Dwi Anita Suryandari Yurnadi Yunardi Puji Sari |
| author_sort | Dwi Anita Suryandari |
| collection | DOAJ |
| description | The aim of this study is to find out Y chromosome microdeletion in Indonesian azoospermic men. This study used the PCR method with five STS to locate deletion on three different subregions (AZFa, AZFb, and AZFc) of azoospermic men and one STS to amplify SRY gen which act as an internal control. In this study we detected two of 35 (5,7%) azoospermic men had microdeletion Yq. One had microdeletion on subregion AZFa (sY84) and AZFb (RBMY1) and the other one on subregion AZFc (sY254 and sY255). Therefore microdeletion of the Y chromosome in Indonesian azoospermic men excist. Examination of microdeletion of Y chromosomes in azoospermic men is important if they are going to participate in the Intra Cytoplasmic Infection Program to avoid genetic disorders of their descendants. |
| first_indexed | 2024-03-12T19:41:10Z |
| format | Article |
| id | doaj.art-3809c3a43afe419da33aac4cbd3fdccc |
| institution | Directory Open Access Journal |
| issn | 2356-3664 2356-3656 |
| language | English |
| last_indexed | 2024-03-12T19:41:10Z |
| publishDate | 2010-10-01 |
| publisher | Universitas Indonesia |
| record_format | Article |
| series | Makara Journal of Health Research |
| spelling | doaj.art-3809c3a43afe419da33aac4cbd3fdccc2023-08-02T03:49:46ZengUniversitas IndonesiaMakara Journal of Health Research2356-36642356-36562010-10-01101414610.7454/msk.v10i1.165162Analysis of Y Chromosome Microdeletion in Indonesian MalesDwi Anita Suryandari0Yurnadi Yunardi1Puji Sari2Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430The aim of this study is to find out Y chromosome microdeletion in Indonesian azoospermic men. This study used the PCR method with five STS to locate deletion on three different subregions (AZFa, AZFb, and AZFc) of azoospermic men and one STS to amplify SRY gen which act as an internal control. In this study we detected two of 35 (5,7%) azoospermic men had microdeletion Yq. One had microdeletion on subregion AZFa (sY84) and AZFb (RBMY1) and the other one on subregion AZFc (sY254 and sY255). Therefore microdeletion of the Y chromosome in Indonesian azoospermic men excist. Examination of microdeletion of Y chromosomes in azoospermic men is important if they are going to participate in the Intra Cytoplasmic Infection Program to avoid genetic disorders of their descendants.http://journal.ui.ac.id/index.php/health/article/view/165Y-chromosomeAzoospermiamicrodeletion |
| spellingShingle | Dwi Anita Suryandari Yurnadi Yunardi Puji Sari Analysis of Y Chromosome Microdeletion in Indonesian Males Makara Journal of Health Research Y-chromosome Azoospermia microdeletion |
| title | Analysis of Y Chromosome Microdeletion in Indonesian Males |
| title_full | Analysis of Y Chromosome Microdeletion in Indonesian Males |
| title_fullStr | Analysis of Y Chromosome Microdeletion in Indonesian Males |
| title_full_unstemmed | Analysis of Y Chromosome Microdeletion in Indonesian Males |
| title_short | Analysis of Y Chromosome Microdeletion in Indonesian Males |
| title_sort | analysis of y chromosome microdeletion in indonesian males |
| topic | Y-chromosome Azoospermia microdeletion |
| url | http://journal.ui.ac.id/index.php/health/article/view/165 |
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