Regional brain activation supporting cognitive control in the context of reward is associated with treated adolescents’ marijuana problem severity at follow-up: A preliminary study
This preliminary study examined the extent to which regional brain activation during a reward cue antisaccade (AS) task was associated with 6-month treatment outcome in adolescent substance users. Antisaccade performance provides a sensitive measure of executive function and cognitive control, and g...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-12-01
|
| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929315000511 |
| _version_ | 1819259502849949696 |
|---|---|
| author | Tammy Chung David J. Paulsen Charles F. Geier Beatriz Luna Duncan B. Clark |
| author_facet | Tammy Chung David J. Paulsen Charles F. Geier Beatriz Luna Duncan B. Clark |
| author_sort | Tammy Chung |
| collection | DOAJ |
| description | This preliminary study examined the extent to which regional brain activation during a reward cue antisaccade (AS) task was associated with 6-month treatment outcome in adolescent substance users. Antisaccade performance provides a sensitive measure of executive function and cognitive control, and generally improves with reward cues. We hypothesized that when preparing to execute an AS, greater activation in regions associated with cognitive and oculomotor control supporting AS, particularly during reward cue trials, would be associated with lower substance use severity at 6-month follow-up. Adolescents (n = 14, ages 14–18) recruited from community-based outpatient treatment completed an fMRI reward cue AS task (reward and neutral conditions), and provided follow-up data. Results indicated that AS errors decreased in reward, compared to neutral, trials. AS behavioral performance, however, was not associated with treatment outcome. As hypothesized, activation in regions of interest (ROIs) associated with cognitive (e.g., ventrolateral prefrontal cortex) and oculomotor control (e.g., supplementary eye field) during reward trials were inversely correlated with marijuana problem severity at 6-months. ROI activation during neutral trials was not associated with outcomes. Results support the role of motivational (reward cue) factors to enhance cognitive control processes, and suggest a potential brain-based correlate of youth treatment outcome. |
| first_indexed | 2024-12-23T19:11:02Z |
| format | Article |
| id | doaj.art-380ad1a766554cdd81bc239c130740f7 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 1878-9307 |
| language | English |
| last_indexed | 2024-12-23T19:11:02Z |
| publishDate | 2015-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-380ad1a766554cdd81bc239c130740f72022-12-21T17:34:27ZengElsevierDevelopmental Cognitive Neuroscience1878-92931878-93072015-12-0116C9310010.1016/j.dcn.2015.05.004Regional brain activation supporting cognitive control in the context of reward is associated with treated adolescents’ marijuana problem severity at follow-up: A preliminary studyTammy Chung0David J. Paulsen1Charles F. Geier2Beatriz Luna3Duncan B. Clark4University of Pittsburgh Medical Center, 3811 O’Hara Street, Pittsburgh, PA 15213, United StatesUniversity of Pittsburgh Medical Center, 3811 O’Hara Street, Pittsburgh, PA 15213, United StatesPennsylvania State University, 120B South Henderson, State College, PA 16802, United StatesUniversity of Pittsburgh Medical Center, 3811 O’Hara Street, Pittsburgh, PA 15213, United StatesUniversity of Pittsburgh Medical Center, 3811 O’Hara Street, Pittsburgh, PA 15213, United StatesThis preliminary study examined the extent to which regional brain activation during a reward cue antisaccade (AS) task was associated with 6-month treatment outcome in adolescent substance users. Antisaccade performance provides a sensitive measure of executive function and cognitive control, and generally improves with reward cues. We hypothesized that when preparing to execute an AS, greater activation in regions associated with cognitive and oculomotor control supporting AS, particularly during reward cue trials, would be associated with lower substance use severity at 6-month follow-up. Adolescents (n = 14, ages 14–18) recruited from community-based outpatient treatment completed an fMRI reward cue AS task (reward and neutral conditions), and provided follow-up data. Results indicated that AS errors decreased in reward, compared to neutral, trials. AS behavioral performance, however, was not associated with treatment outcome. As hypothesized, activation in regions of interest (ROIs) associated with cognitive (e.g., ventrolateral prefrontal cortex) and oculomotor control (e.g., supplementary eye field) during reward trials were inversely correlated with marijuana problem severity at 6-months. ROI activation during neutral trials was not associated with outcomes. Results support the role of motivational (reward cue) factors to enhance cognitive control processes, and suggest a potential brain-based correlate of youth treatment outcome.http://www.sciencedirect.com/science/article/pii/S1878929315000511AdolescentTreatment outcomeMarijuanafMRIAntisaccadeReward |
| spellingShingle | Tammy Chung David J. Paulsen Charles F. Geier Beatriz Luna Duncan B. Clark Regional brain activation supporting cognitive control in the context of reward is associated with treated adolescents’ marijuana problem severity at follow-up: A preliminary study Developmental Cognitive Neuroscience Adolescent Treatment outcome Marijuana fMRI Antisaccade Reward |
| title | Regional brain activation supporting cognitive control in the context of reward is associated with treated adolescents’ marijuana problem severity at follow-up: A preliminary study |
| title_full | Regional brain activation supporting cognitive control in the context of reward is associated with treated adolescents’ marijuana problem severity at follow-up: A preliminary study |
| title_fullStr | Regional brain activation supporting cognitive control in the context of reward is associated with treated adolescents’ marijuana problem severity at follow-up: A preliminary study |
| title_full_unstemmed | Regional brain activation supporting cognitive control in the context of reward is associated with treated adolescents’ marijuana problem severity at follow-up: A preliminary study |
| title_short | Regional brain activation supporting cognitive control in the context of reward is associated with treated adolescents’ marijuana problem severity at follow-up: A preliminary study |
| title_sort | regional brain activation supporting cognitive control in the context of reward is associated with treated adolescents marijuana problem severity at follow up a preliminary study |
| topic | Adolescent Treatment outcome Marijuana fMRI Antisaccade Reward |
| url | http://www.sciencedirect.com/science/article/pii/S1878929315000511 |
| work_keys_str_mv | AT tammychung regionalbrainactivationsupportingcognitivecontrolinthecontextofrewardisassociatedwithtreatedadolescentsmarijuanaproblemseverityatfollowupapreliminarystudy AT davidjpaulsen regionalbrainactivationsupportingcognitivecontrolinthecontextofrewardisassociatedwithtreatedadolescentsmarijuanaproblemseverityatfollowupapreliminarystudy AT charlesfgeier regionalbrainactivationsupportingcognitivecontrolinthecontextofrewardisassociatedwithtreatedadolescentsmarijuanaproblemseverityatfollowupapreliminarystudy AT beatrizluna regionalbrainactivationsupportingcognitivecontrolinthecontextofrewardisassociatedwithtreatedadolescentsmarijuanaproblemseverityatfollowupapreliminarystudy AT duncanbclark regionalbrainactivationsupportingcognitivecontrolinthecontextofrewardisassociatedwithtreatedadolescentsmarijuanaproblemseverityatfollowupapreliminarystudy |