T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes
T cell receptors are generated by somatic gene recombination, and are normally selected against autoreactivity. Here the authors show that CD4 T cells from patients with autoimmune type 1 diabetes have shorter TCRβ sequences, broader repertoire diversity, and more repertoire sharing than those from...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01925-2 |
| _version_ | 1818343374463172608 |
|---|---|
| author | Iria Gomez-Tourino Yogesh Kamra Roman Baptista Anna Lorenc Mark Peakman |
| author_facet | Iria Gomez-Tourino Yogesh Kamra Roman Baptista Anna Lorenc Mark Peakman |
| author_sort | Iria Gomez-Tourino |
| collection | DOAJ |
| description | T cell receptors are generated by somatic gene recombination, and are normally selected against autoreactivity. Here the authors show that CD4 T cells from patients with autoimmune type 1 diabetes have shorter TCRβ sequences, broader repertoire diversity, and more repertoire sharing than those from healthy individuals. |
| first_indexed | 2024-12-13T16:29:34Z |
| format | Article |
| id | doaj.art-380b4cadc81944b194b1293a9b9b42f5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:29:34Z |
| publishDate | 2017-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-380b4cadc81944b194b1293a9b9b42f52022-12-21T23:38:32ZengNature PortfolioNature Communications2041-17232017-11-018111510.1038/s41467-017-01925-2T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetesIria Gomez-Tourino0Yogesh Kamra1Roman Baptista2Anna Lorenc3Mark Peakman4Department of Immunobiology, Faculty of Life Sciences & Medicine, King’s College London, 2nd Floor, Borough Wing, Guy’s HospitalDepartment of Immunobiology, Faculty of Life Sciences & Medicine, King’s College London, 2nd Floor, Borough Wing, Guy’s HospitalDepartment of Immunobiology, Faculty of Life Sciences & Medicine, King’s College London, 2nd Floor, Borough Wing, Guy’s HospitalDepartment of Immunobiology, Faculty of Life Sciences & Medicine, King’s College London, 2nd Floor, Borough Wing, Guy’s HospitalDepartment of Immunobiology, Faculty of Life Sciences & Medicine, King’s College London, 2nd Floor, Borough Wing, Guy’s HospitalT cell receptors are generated by somatic gene recombination, and are normally selected against autoreactivity. Here the authors show that CD4 T cells from patients with autoimmune type 1 diabetes have shorter TCRβ sequences, broader repertoire diversity, and more repertoire sharing than those from healthy individuals.https://doi.org/10.1038/s41467-017-01925-2 |
| spellingShingle | Iria Gomez-Tourino Yogesh Kamra Roman Baptista Anna Lorenc Mark Peakman T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes Nature Communications |
| title | T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes |
| title_full | T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes |
| title_fullStr | T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes |
| title_full_unstemmed | T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes |
| title_short | T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes |
| title_sort | t cell receptor β chains display abnormal shortening and repertoire sharing in type 1 diabetes |
| url | https://doi.org/10.1038/s41467-017-01925-2 |
| work_keys_str_mv | AT iriagomeztourino tcellreceptorbchainsdisplayabnormalshorteningandrepertoiresharingintype1diabetes AT yogeshkamra tcellreceptorbchainsdisplayabnormalshorteningandrepertoiresharingintype1diabetes AT romanbaptista tcellreceptorbchainsdisplayabnormalshorteningandrepertoiresharingintype1diabetes AT annalorenc tcellreceptorbchainsdisplayabnormalshorteningandrepertoiresharingintype1diabetes AT markpeakman tcellreceptorbchainsdisplayabnormalshorteningandrepertoiresharingintype1diabetes |