Acceleration of Skin Wound Healing with Tragacanth (Astragalus) Preparation: An Experimental Pilot Study in Rats
Gum tragacanth is a natural complex mixture of polysaccharides and alkaline minerals extracted from species of Astragalus plant, which is found widely in arid regions of the Middle East. In a pilot experimental study we examined the effects of its topical application on wound healing in ten albino a...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2014-01-01
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| Series: | Acta Medica Iranica |
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| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/4753 |
| _version_ | 1818207020906446848 |
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| author | Ehsan Fayazzadeh Sina Rahimpour Seyed Mohsen Ahmadi Shahrokh Farzampour Maryam Sotoudeh Anvari Mohammad Ali Boroumand Seyed Hossein Ahmadi |
| author_facet | Ehsan Fayazzadeh Sina Rahimpour Seyed Mohsen Ahmadi Shahrokh Farzampour Maryam Sotoudeh Anvari Mohammad Ali Boroumand Seyed Hossein Ahmadi |
| author_sort | Ehsan Fayazzadeh |
| collection | DOAJ |
| description | Gum tragacanth is a natural complex mixture of polysaccharides and alkaline minerals extracted from species of Astragalus plant, which is found widely in arid regions of the Middle East. In a pilot experimental study we examined the effects of its topical application on wound healing in ten albino adult male rats. Two similar parasagittal elliptical full-thickness wounds (control vs. test samples) were created on the dorsum of each animal. Test group samples were fully covered by a thin layer of gum tragacanth daily. The extent of wound healing was evaluated by planimetric analysis on multiple occasions during the 10-day study period. On the 7th day of the study, the percent of wound closure was significantly higher in gum tragacanth-treated specimens compared to the control samples (87%±2% vs. 70%±4%, P<0.001). The majority of wounds in the test group were completely closed by the 10th day of the study. The difference in wound healing index measured by histological examination on day 10 of the study was also statistically meaningful between the two groups (0.624±0.097 vs. 0.255±0.063, P<0.05). The results of this study clearly showed the useful effects of topical application of gum tragacanth in acceleration of skin wound contraction and healing. More studies are encouraged to identify the implicating agents and precisely understand the mechanism by which they exert their wound healing effects. |
| first_indexed | 2024-12-12T04:22:17Z |
| format | Article |
| id | doaj.art-380b55ff63314369b58b0958d3f4a936 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-12T04:22:17Z |
| publishDate | 2014-01-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-380b55ff63314369b58b0958d3f4a9362022-12-22T00:38:18ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942014-01-015214706Acceleration of Skin Wound Healing with Tragacanth (Astragalus) Preparation: An Experimental Pilot Study in RatsEhsan Fayazzadeh0Sina Rahimpour1Seyed Mohsen Ahmadi2Shahrokh Farzampour3Maryam Sotoudeh Anvari4Mohammad Ali Boroumand5Seyed Hossein Ahmadi6Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. AND Animal Research Laboratory, Faculty of Medicine, Artesh University of Medical Sciences, Tehran, Iran.Animal Research Laboratory, Faculty of Medicine, Artesh University of Medical Sciences, Tehran, Iran.Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Animal Research Laboratory, Faculty of Medicine, Artesh University of Medical Sciences, Tehran, Iran.Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Gum tragacanth is a natural complex mixture of polysaccharides and alkaline minerals extracted from species of Astragalus plant, which is found widely in arid regions of the Middle East. In a pilot experimental study we examined the effects of its topical application on wound healing in ten albino adult male rats. Two similar parasagittal elliptical full-thickness wounds (control vs. test samples) were created on the dorsum of each animal. Test group samples were fully covered by a thin layer of gum tragacanth daily. The extent of wound healing was evaluated by planimetric analysis on multiple occasions during the 10-day study period. On the 7th day of the study, the percent of wound closure was significantly higher in gum tragacanth-treated specimens compared to the control samples (87%±2% vs. 70%±4%, P<0.001). The majority of wounds in the test group were completely closed by the 10th day of the study. The difference in wound healing index measured by histological examination on day 10 of the study was also statistically meaningful between the two groups (0.624±0.097 vs. 0.255±0.063, P<0.05). The results of this study clearly showed the useful effects of topical application of gum tragacanth in acceleration of skin wound contraction and healing. More studies are encouraged to identify the implicating agents and precisely understand the mechanism by which they exert their wound healing effects.https://acta.tums.ac.ir/index.php/acta/article/view/4753AstragalusTragacanthSkinWound healing |
| spellingShingle | Ehsan Fayazzadeh Sina Rahimpour Seyed Mohsen Ahmadi Shahrokh Farzampour Maryam Sotoudeh Anvari Mohammad Ali Boroumand Seyed Hossein Ahmadi Acceleration of Skin Wound Healing with Tragacanth (Astragalus) Preparation: An Experimental Pilot Study in Rats Acta Medica Iranica Astragalus Tragacanth Skin Wound healing |
| title | Acceleration of Skin Wound Healing with Tragacanth (Astragalus) Preparation: An Experimental Pilot Study in Rats |
| title_full | Acceleration of Skin Wound Healing with Tragacanth (Astragalus) Preparation: An Experimental Pilot Study in Rats |
| title_fullStr | Acceleration of Skin Wound Healing with Tragacanth (Astragalus) Preparation: An Experimental Pilot Study in Rats |
| title_full_unstemmed | Acceleration of Skin Wound Healing with Tragacanth (Astragalus) Preparation: An Experimental Pilot Study in Rats |
| title_short | Acceleration of Skin Wound Healing with Tragacanth (Astragalus) Preparation: An Experimental Pilot Study in Rats |
| title_sort | acceleration of skin wound healing with tragacanth astragalus preparation an experimental pilot study in rats |
| topic | Astragalus Tragacanth Skin Wound healing |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/4753 |
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