Alginate microgels encapsulation strategy of silver nanoparticles active against Candida albicans
Nanoparticles (NPs), offering high specific surface, are considered as the best potential anti-microbial agents for a wide range of medical nanotechnology. Among them, silver NPs (AgNPs) allow high biocidal activity. A design of ecological capsules is proposed where AgNPs of 22 nm in diameter are gr...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893923001251 |
| _version_ | 1827577174528360448 |
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| author | Mélanie Marquis Dafne Musino Valentin Gemin Laetitia Kolypczuk Delphine Passerini Isabelle Capron |
| author_facet | Mélanie Marquis Dafne Musino Valentin Gemin Laetitia Kolypczuk Delphine Passerini Isabelle Capron |
| author_sort | Mélanie Marquis |
| collection | DOAJ |
| description | Nanoparticles (NPs), offering high specific surface, are considered as the best potential anti-microbial agents for a wide range of medical nanotechnology. Among them, silver NPs (AgNPs) allow high biocidal activity. A design of ecological capsules is proposed where AgNPs of 22 nm in diameter are grafted on the surface of biobased nanocrystals obtained from cellulose (CNC) and chitin (ChiNC). These silver nanohybrids are dispersed in calcium-alginate microgels of 45–50 µm in diameter using microfluidic tools. Such double level of immobilization of AgNPs leads to highly stable carriers, prolongs shelf life and raises bioactivity, with a precise control of well dispersed AgNPs as determined by scanning transmission electron microscopy, UV-Vis spectroscopy and atomic absorption spectroscopy. Preliminary tests for antimicrobial activities of these new microgels have shown a significant inhibitory effect on Candida albicans, the most common fungal pathogen, responsible for thrush and vaginal yeast infections, for very low levels of silver. |
| first_indexed | 2024-03-08T21:24:04Z |
| format | Article |
| id | doaj.art-380c9ee9b77a4b838e593f129d5f8373 |
| institution | Directory Open Access Journal |
| issn | 2666-8939 |
| language | English |
| last_indexed | 2024-03-08T21:24:04Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj.art-380c9ee9b77a4b838e593f129d5f83732023-12-21T07:37:52ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392023-12-016100405Alginate microgels encapsulation strategy of silver nanoparticles active against Candida albicansMélanie Marquis0Dafne Musino1Valentin Gemin2Laetitia Kolypczuk3Delphine Passerini4Isabelle Capron5INRAE, UR1268 Biopolymers Interactions and Assemblies, 44300 Nantes, France; Oniris, INRAE, UMR0703 Physiopathologie Animale et BioThérapie du muscle et du système nerveux, 44307 Nantes, France; Corresponding author at: Oniris, INRAE, UMR0703 Physiopathologie Animale et BioThérapie du muscle et du système nerveux, 44307 Nantes, France.INRAE, UR1268 Biopolymers Interactions and Assemblies, 44300 Nantes, FranceINRAE, UR1268 Biopolymers Interactions and Assemblies, 44300 Nantes, FranceIfremer, MASAE Microbiologie Aliment Santé Environnement, 44000 Nantes, FranceIfremer, MASAE Microbiologie Aliment Santé Environnement, 44000 Nantes, FranceINRAE, UR1268 Biopolymers Interactions and Assemblies, 44300 Nantes, France; Corresponding author at: Oniris, INRAE, UMR0703 Physiopathologie Animale et BioThérapie du muscle et du système nerveux, 44307 Nantes, France.Nanoparticles (NPs), offering high specific surface, are considered as the best potential anti-microbial agents for a wide range of medical nanotechnology. Among them, silver NPs (AgNPs) allow high biocidal activity. A design of ecological capsules is proposed where AgNPs of 22 nm in diameter are grafted on the surface of biobased nanocrystals obtained from cellulose (CNC) and chitin (ChiNC). These silver nanohybrids are dispersed in calcium-alginate microgels of 45–50 µm in diameter using microfluidic tools. Such double level of immobilization of AgNPs leads to highly stable carriers, prolongs shelf life and raises bioactivity, with a precise control of well dispersed AgNPs as determined by scanning transmission electron microscopy, UV-Vis spectroscopy and atomic absorption spectroscopy. Preliminary tests for antimicrobial activities of these new microgels have shown a significant inhibitory effect on Candida albicans, the most common fungal pathogen, responsible for thrush and vaginal yeast infections, for very low levels of silver.http://www.sciencedirect.com/science/article/pii/S2666893923001251Cellulose nanocrystal (CNC)Chitin nanocrystal (ChiNC)HybridMicrofluidicHydrogelAntimicrobial activities |
| spellingShingle | Mélanie Marquis Dafne Musino Valentin Gemin Laetitia Kolypczuk Delphine Passerini Isabelle Capron Alginate microgels encapsulation strategy of silver nanoparticles active against Candida albicans Carbohydrate Polymer Technologies and Applications Cellulose nanocrystal (CNC) Chitin nanocrystal (ChiNC) Hybrid Microfluidic Hydrogel Antimicrobial activities |
| title | Alginate microgels encapsulation strategy of silver nanoparticles active against Candida albicans |
| title_full | Alginate microgels encapsulation strategy of silver nanoparticles active against Candida albicans |
| title_fullStr | Alginate microgels encapsulation strategy of silver nanoparticles active against Candida albicans |
| title_full_unstemmed | Alginate microgels encapsulation strategy of silver nanoparticles active against Candida albicans |
| title_short | Alginate microgels encapsulation strategy of silver nanoparticles active against Candida albicans |
| title_sort | alginate microgels encapsulation strategy of silver nanoparticles active against candida albicans |
| topic | Cellulose nanocrystal (CNC) Chitin nanocrystal (ChiNC) Hybrid Microfluidic Hydrogel Antimicrobial activities |
| url | http://www.sciencedirect.com/science/article/pii/S2666893923001251 |
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