Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX

Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX

Epithelial tissues are primed to respond to insults by activating epithelial cell motility and rapid inflammation. Such responses are also elicited upon overexpression of the membrane-bound protease, Matriptase, or mutation of its inhibitor, Hai1. Unrestricted Matriptase activity also predisposes to...

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Bibliographic Details
Main Authors: Jiajia Ma, Claire A Scott, Ying Na Ho, Harsha Mahabaleshwar, Katherine S Marsay, Changqing Zhang, Christopher KJ Teow, Ser Sue Ng, Weibin Zhang, Vinay Tergaonkar, Lynda J Partridge, Sudipto Roy, Enrique Amaya, Tom J Carney
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
Matriptase
RSK
inflammation
Hai1
Par2
Gq
Online Access:https://elifesciences.org/articles/66596

Internet

https://elifesciences.org/articles/66596

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