Pre-B cell receptor signaling induces immunoglobulin κ locus accessibility by functional redistribution of enhancer-mediated chromatin interactions.

Pre-B cell receptor signaling induces immunoglobulin κ locus accessibility by functional redistribution of enhancer-mediated chromatin interactions.

During B cell development, the precursor B cell receptor (pre-BCR) checkpoint is thought to increase immunoglobulin κ light chain (Igκ) locus accessibility to the V(D)J recombinase. Accordingly, pre-B cells lacking the pre-BCR signaling molecules Btk or Slp65 showed reduced germline V(κ) transcripti...

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Bibliographic Details
Main Authors: Ralph Stadhouders, Marjolein J W de Bruijn, Magdalena B Rother, Saravanan Yuvaraj, Claudia Ribeiro de Almeida, Petros Kolovos, Menno C Van Zelm, Wilfred van Ijcken, Frank Grosveld, Eric Soler, Rudi W Hendriks
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-02-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24558349/?tool=EBI

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