Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyunsaturated fatty acids in vitro and in vivo.

Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyunsaturated fatty acids in vitro and in vivo.

Cancer associated fibroblasts (CAFs) are responsible for tumor growth, angiogenesis, invasion, and metastasis. Matrix metalloproteinase (MMP)-9 secreted from cancer stroma populated by CAFs is a prerequisite for cancer angiogenesis and metastasis. Omega-3 polyunsaturated fatty acids (omega-3 PUFA) h...

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Main Authors: Ayumi Taguchi, Kei Kawana, Kensuke Tomio, Aki Yamashita, Yosuke Isobe, Kazunori Nagasaka, Kaori Koga, Tomoko Inoue, Haruka Nishida, Satoko Kojima, Katsuyuki Adachi, Yoko Matsumoto, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Jing X Kang, Hiroyuki Arai, Makoto Arita, Yutaka Osuga, Tomoyuki Fujii
格式: Article
語言:English
出版: Public Library of Science (PLoS) 2014-01-01
叢編:PLoS ONE
在線閱讀:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089605&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089605&type=printable

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